UniProtKB - Q23997 (C5210_DROME)
Protein
Imaginal disk growth factor 6
Gene
Idgf6
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity).By similarity
Caution
Lacks the typical Glu active site in position 165 that is replaced by a Gln residue, exhibits no chitinolytic activity towards either polymeric and oligomeric substrates. Its precise function remains unclear.Curated
GO - Molecular functioni
- chitinase activity Source: UniProtKB
- chitin binding Source: FlyBase
- imaginal disc growth factor receptor binding Source: FlyBase
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- chitin-based cuticle development Source: FlyBase
- chitin catabolic process Source: GO_Central
- cuticle chitin catabolic process Source: UniProtKB
- ecdysis, chitin-based cuticle Source: FlyBase
- imaginal disc development Source: FlyBase
- wound healing Source: FlyBase
Keywordsi
Molecular function | Developmental protein |
Ligand | Chitin-binding |
Enzyme and pathway databases
Reactomei | R-DME-189085, Digestion of dietary carbohydrate R-DME-6798695, Neutrophil degranulation |
Protein family/group databases
CAZyi | GH18, Glycoside Hydrolase Family 18 |
Names & Taxonomyi
Protein namesi | Recommended name: Imaginal disk growth factor 6Imported |
Gene namesi | Name:Idgf6Imported ORF Names:CG5210Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0013763, Idgf6 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Note: It is transported to target tissues via hemolymph.
Extracellular region or secreted
- extracellular region Source: FlyBase
- extracellular space Source: FlyBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
ChainiPRO_0000011979 | 19 – 452 | Imaginal disk growth factor 6Add BLAST | 434 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 60 | PROSITE-ProRule annotation | ||
Glycosylationi | 233 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 352 ↔ 435 | By similarity |
Post-translational modificationi
Glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q23997 |
PRIDEi | Q23997 |
Expressioni
Tissue specificityi
In larvae, it is expressed in the fat body and by hemocytes.1 Publication
Developmental stagei
Expressed throughout development and in adults.1 Publication
Gene expression databases
Bgeei | FBgn0013763, Expressed in embryonic/larval hemocyte (Drosophila) and 53 other tissues |
ExpressionAtlasi | Q23997, baseline and differential |
Genevisiblei | Q23997, DM |
Interactioni
GO - Molecular functioni
- imaginal disc growth factor receptor binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 62579, 1 interactor |
IntActi | Q23997, 1 interactor |
STRINGi | 7227.FBpp0086257 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 452 | GH18PROSITE-ProRule annotationAdd BLAST | 424 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2806, Eukaryota |
GeneTreei | ENSGT00940000167840 |
HOGENOMi | CLU_002833_3_2_1 |
InParanoidi | Q23997 |
OMAi | LQFCDYL |
OrthoDBi | 482694at2759 |
PhylomeDBi | Q23997 |
Family and domain databases
CDDi | cd02873, GH18_IDGF, 1 hit |
Gene3Di | 3.10.50.10, 1 hit |
InterProi | View protein in InterPro IPR011583, Chitinase_II IPR029070, Chitinase_insertion_sf IPR001223, Glyco_hydro18_cat IPR017853, Glycoside_hydrolase_SF IPR015520, IDGF |
PANTHERi | PTHR11177:SF235, PTHR11177:SF235, 1 hit |
Pfami | View protein in Pfam PF00704, Glyco_hydro_18, 1 hit |
SMARTi | View protein in SMART SM00636, Glyco_18, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF54556, SSF54556, 1 hit |
PROSITEi | View protein in PROSITE PS51910, GH18_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q23997-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIIKALAIVS LCLASIQASK VGAPQLPKKH LVCYYDSASF VKEGLGKLVI
60 70 80 90 100
DELEPALQFC DYLVYGYAGI ERDSHKAVSL NQQLDLDLGK GLYRTVTRLK
110 120 130 140 150
RKYPNVKILL SVGGDKDIEL DKDAKELPNK YLELLESPTG RTRFVNTVYS
160 170 180 190 200
LVKTYGFDGL DVAWQFPKNK PKKVHSGIGS LWKGFKKVFS GDSIVDEKSE
210 220 230 240 250
EHKEQFTALL RDVKNAFRPD NLLLSTTVLP NVNSSLFYDI PAVVNYLDFV
260 270 280 290 300
NLGTFDFFTP QRNPEVADYA APIYELSERN PEFNVAAQVK YWLRNNCPAS
310 320 330 340 350
KINVGVATYG RPWKLTDDSG DTGVPPVKDV KDEAPVGGNT QVPGIYSWPE
360 370 380 390 400
VCALLPNQNN AYLKGANAPL IKVQDPAKRF GSYAYRAADK KGDNGIWVSF
410 420 430 440 450
EDPDTAADKA GYVRTENLGG VALFDLSYDD FRGLCTNEKY PILRAIKYRL
TN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4LFJ1 | A0A0B4LFJ1_DROME | Imaginal disc growth factor 6, isof... | Idgf6 Chit, chit, Chit13, Cht13, DmDS47 | 452 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 180 | S → N in AAC48306 (PubMed:7875581).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 228 | V → L in strain: ZBMEL229. 1 Publication | 1 | |
Natural varianti | 266 | V → I in strain: ZBMEL131, ZBMEL157, ZBMEL186 and ZBMEL191. 2 Publications | 1 | |
Natural varianti | 296 | N → S in strain: ZBMEL131, ZBMEL186, ZBMEL229, ZBMEL377 and ZBMEL398. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13825 mRNA Translation: AAC48306.1 FN544129 Genomic DNA Translation: CBA35210.1 FN544130 Genomic DNA Translation: CBA35211.1 FN544131 Genomic DNA Translation: CBA35212.1 FN544132 Genomic DNA Translation: CBA35213.1 FN544133 Genomic DNA Translation: CBA35214.1 FN544134 Genomic DNA Translation: CBA35215.1 FN544135 Genomic DNA Translation: CBA35216.1 FN544136 Genomic DNA Translation: CBA35217.1 FN544137 Genomic DNA Translation: CBA35218.1 FN544138 Genomic DNA Translation: CBA35219.1 AE013599 Genomic DNA Translation: AAF57965.1 AY058510 mRNA Translation: AAL13739.1 BT029919 mRNA Translation: ABM92793.1 |
PIRi | JC4038 |
RefSeqi | NP_001286499.1, NM_001299570.1 NP_477081.1, NM_057733.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0087111; FBpp0086257; FBgn0013763 FBtr0340066; FBpp0309072; FBgn0013763 |
GeneIDi | 36868 |
KEGGi | dme:Dmel_CG5210 |
UCSCi | CG5210-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13825 mRNA Translation: AAC48306.1 FN544129 Genomic DNA Translation: CBA35210.1 FN544130 Genomic DNA Translation: CBA35211.1 FN544131 Genomic DNA Translation: CBA35212.1 FN544132 Genomic DNA Translation: CBA35213.1 FN544133 Genomic DNA Translation: CBA35214.1 FN544134 Genomic DNA Translation: CBA35215.1 FN544135 Genomic DNA Translation: CBA35216.1 FN544136 Genomic DNA Translation: CBA35217.1 FN544137 Genomic DNA Translation: CBA35218.1 FN544138 Genomic DNA Translation: CBA35219.1 AE013599 Genomic DNA Translation: AAF57965.1 AY058510 mRNA Translation: AAL13739.1 BT029919 mRNA Translation: ABM92793.1 |
PIRi | JC4038 |
RefSeqi | NP_001286499.1, NM_001299570.1 NP_477081.1, NM_057733.4 |
3D structure databases
SMRi | Q23997 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62579, 1 interactor |
IntActi | Q23997, 1 interactor |
STRINGi | 7227.FBpp0086257 |
Protein family/group databases
CAZyi | GH18, Glycoside Hydrolase Family 18 |
Proteomic databases
PaxDbi | Q23997 |
PRIDEi | Q23997 |
Genome annotation databases
EnsemblMetazoai | FBtr0087111; FBpp0086257; FBgn0013763 FBtr0340066; FBpp0309072; FBgn0013763 |
GeneIDi | 36868 |
KEGGi | dme:Dmel_CG5210 |
UCSCi | CG5210-RA, d. melanogaster |
Organism-specific databases
CTDi | 36868 |
FlyBasei | FBgn0013763, Idgf6 |
Phylogenomic databases
eggNOGi | KOG2806, Eukaryota |
GeneTreei | ENSGT00940000167840 |
HOGENOMi | CLU_002833_3_2_1 |
InParanoidi | Q23997 |
OMAi | LQFCDYL |
OrthoDBi | 482694at2759 |
PhylomeDBi | Q23997 |
Enzyme and pathway databases
Reactomei | R-DME-189085, Digestion of dietary carbohydrate R-DME-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 36868, 0 hits in 1 CRISPR screen |
GenomeRNAii | 36868 |
PROi | PR:Q23997 |
Gene expression databases
Bgeei | FBgn0013763, Expressed in embryonic/larval hemocyte (Drosophila) and 53 other tissues |
ExpressionAtlasi | Q23997, baseline and differential |
Genevisiblei | Q23997, DM |
Family and domain databases
CDDi | cd02873, GH18_IDGF, 1 hit |
Gene3Di | 3.10.50.10, 1 hit |
InterProi | View protein in InterPro IPR011583, Chitinase_II IPR029070, Chitinase_insertion_sf IPR001223, Glyco_hydro18_cat IPR017853, Glycoside_hydrolase_SF IPR015520, IDGF |
PANTHERi | PTHR11177:SF235, PTHR11177:SF235, 1 hit |
Pfami | View protein in Pfam PF00704, Glyco_hydro_18, 1 hit |
SMARTi | View protein in SMART SM00636, Glyco_18, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF54556, SSF54556, 1 hit |
PROSITEi | View protein in PROSITE PS51910, GH18_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C5210_DROME | |
Accessioni | Q23997Primary (citable) accession number: Q23997 Secondary accession number(s): A2RVC8 Q9V7S9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | March 15, 2004 | |
Last modified: | August 12, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries