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Entry version 165 (07 Oct 2020)
Sequence version 2 (15 Aug 2003)
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Protein

Protein deltex

Gene

dx

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri548 – 603RING-typePROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processNotch signaling pathway, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2122948, Activated NOTCH1 Transmits Signal to the Nucleus

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q23985

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein deltex
Alternative name(s):
Probable E3 ubiquitin-protein ligase deltex (EC:2.3.2.27By similarity)
RING-type E3 ubiquitin transferase deltexCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dx
ORF Names:CG3929
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000524, dx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi476 – 484Missing : Dominant-negative mutant that inhibits Notch signaling. 1 Publication9
Mutagenesisi571H → A: Loss of function. Abolishes homomultimerization; when associated with A-574. 1 Publication1
Mutagenesisi574H → A: Loss of function. Abolishes homomultimerization; when associated with A-571. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002190791 – 738Protein deltexAdd BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei425Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23985

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q23985

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at low levels throughout embryogenesis and in larvae.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000524, Expressed in wing disc (Drosophila) and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q23985, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q23985, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimer; the oligomerization is required for its function.

Interacts with the ankyrin repeats of Notch.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
58076, 77 interactors

Database of interacting proteins

More...
DIPi
DIP-18159N

Protein interaction database and analysis system

More...
IntActi
Q23985, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070876

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1738
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q23985

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q23985

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 118WWE 1PROSITE-ProRule annotationAdd BLAST84
Domaini119 – 201WWE 2PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 304Interaction with NotchAdd BLAST304

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi480 – 484SH3-bindingSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi251 – 303Gln/His-rich (OPA repeat)Add BLAST53
Compositional biasi332 – 472Ser-richAdd BLAST141
Compositional biasi489 – 514Poly-Gln (OPA repeat)Add BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Deltex family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri548 – 603RING-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Repeat, SH3-binding, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ9M, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170587

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030422_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23985

KEGG Orthology (KO)

More...
KOi
K06058

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSHAKNM

Database of Orthologous Groups

More...
OrthoDBi
600021at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23985

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09633, Deltex_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039396, Deltex_C
IPR039399, Deltex_C_sf
IPR039398, Deltex_fam
IPR004170, WWE-dom
IPR018123, WWE-dom_subgr
IPR037197, WWE_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12622, PTHR12622, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18102, DTC, 1 hit
PF02825, WWE, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit
SM00678, WWE, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50918, WWE, 2 hits
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q23985-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSAGSAAS GSVVPGGGGS AASSCATMAL STAGSGGPPV NHAHAVCVWE
60 70 80 90 100
FESRGKWLPY SPAVSQHLER AHAKKLTRVM LSDADPSLEQ YYVNVRTMTQ
110 120 130 140 150
ESEAETAGSG LLTIGVRRMF YAPSSPAGKG TKWEWSGGSA DSNNDWRPYN
160 170 180 190 200
MHVQCIIEDA WARGEQTLDL CNTHIGLPYT INFCNLTQLR QPSGPMRSIR
210 220 230 240 250
RTQQAPYPLV KLTPQQANQL KSNSASVSSQ YNTLPKLGDT KSLHRVPMTR
260 270 280 290 300
QQHPLPTSHQ VQQQQHQHQH QQQQQQQHHH QHQQQQHQQQ QQHQMQHHQI
310 320 330 340 350
HHQTAPRKPP KKHSEISTTN LRQILNNLNI FSSSTKHQSN MSTAASASSS
360 370 380 390 400
SSSASLHHAN HLSHAHFSHA KNMLTASMNS HHSRCSEGSL QSQRSSRMGS
410 420 430 440 450
HRSRSRTRTS DTDTNSVKSH RRRPSVDTVS TYLSHESKES LRSRNFAISV
460 470 480 490 500
NDLLDCSLGS DEVFVPSLPP SSLGERAPVP PPLPLHPRQQ QQQQQQQQQL
510 520 530 540 550
QMQQQQQAQQ QQQQSIAGSI VGVDPASDMI SRFVKVVEPP LWPNAQPCPM
560 570 580 590 600
CMEELVHSAQ NPAISLSRCQ HLMHLQCLNG MIIAQQNEMN KNLFIECPVC
610 620 630 640 650
GIVYGEKVGN QPIGSMSWSI ISKNLPGHEG QNTIQIVYDI ASGLQTEEHP
660 670 680 690 700
HPGRAFFAVG FPRICYLPDC PLGRKVLRFL KIAFDRRLLF SIGRSVTTGR
710 720 730
EDVVIWNSVD HKTQFNMFPD PTYLQRTMQQ LVHLGVTD
Length:738
Mass (Da):82,186
Last modified:August 15, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1CF29E024D26AF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO39479 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107 – 108AG → R in AAA18501 (PubMed:8150285).Curated2
Sequence conflicti120F → L in AAA18501 (PubMed:8150285).Curated1
Sequence conflicti188 – 189QL → HV in AAA18501 (PubMed:8150285).Curated2
Sequence conflicti268H → L in AAA18501 (PubMed:8150285).Curated1
Sequence conflicti444R → S in AAO39479 (PubMed:12537569).Curated1
Sequence conflicti468L → V in AAA18501 (PubMed:8150285).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti511Q → L in strain: ZW141. 1 Publication1
Natural varianti514Q → QQ in strain: ZW122. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09789 mRNA Translation: AAA18501.1
AE014298 Genomic DNA Translation: AAF46170.1
BT033059 mRNA Translation: ACE82582.1
BT003476 mRNA Translation: AAO39479.1 Different initiation.
EU217842 Genomic DNA Translation: ABW92761.1
EU217843 Genomic DNA Translation: ABW92762.1
EU217844 Genomic DNA Translation: ABW92763.1
EU217845 Genomic DNA Translation: ABW92764.1
EU217846 Genomic DNA Translation: ABW92765.1
EU217847 Genomic DNA Translation: ABW92766.1
EU217848 Genomic DNA Translation: ABW92767.1
EU217849 Genomic DNA Translation: ABW92768.1
EU217850 Genomic DNA Translation: ABW92769.1
EU217851 Genomic DNA Translation: ABW92770.1
EU217852 Genomic DNA Translation: ABW92771.1
EU217853 Genomic DNA Translation: ABW92772.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S47857

NCBI Reference Sequences

More...
RefSeqi
NP_511064.2, NM_078509.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070914; FBpp0070876; FBgn0000524

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31589

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3929

UCSC genome browser

More...
UCSCi
CG3929-RA, d. melanogaster

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09789 mRNA Translation: AAA18501.1
AE014298 Genomic DNA Translation: AAF46170.1
BT033059 mRNA Translation: ACE82582.1
BT003476 mRNA Translation: AAO39479.1 Different initiation.
EU217842 Genomic DNA Translation: ABW92761.1
EU217843 Genomic DNA Translation: ABW92762.1
EU217844 Genomic DNA Translation: ABW92763.1
EU217845 Genomic DNA Translation: ABW92764.1
EU217846 Genomic DNA Translation: ABW92765.1
EU217847 Genomic DNA Translation: ABW92766.1
EU217848 Genomic DNA Translation: ABW92767.1
EU217849 Genomic DNA Translation: ABW92768.1
EU217850 Genomic DNA Translation: ABW92769.1
EU217851 Genomic DNA Translation: ABW92770.1
EU217852 Genomic DNA Translation: ABW92771.1
EU217853 Genomic DNA Translation: ABW92772.1
PIRiS47857
RefSeqiNP_511064.2, NM_078509.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A90X-ray2.15A26-261[»]
SMRiQ23985
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi58076, 77 interactors
DIPiDIP-18159N
IntActiQ23985, 8 interactors
STRINGi7227.FBpp0070876

PTM databases

iPTMnetiQ23985

Proteomic databases

PaxDbiQ23985

Genome annotation databases

EnsemblMetazoaiFBtr0070914; FBpp0070876; FBgn0000524
GeneIDi31589
KEGGidme:Dmel_CG3929
UCSCiCG3929-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
31589
FlyBaseiFBgn0000524, dx

Phylogenomic databases

eggNOGiENOG502QQ9M, Eukaryota
GeneTreeiENSGT00940000170587
HOGENOMiCLU_030422_4_0_1
InParanoidiQ23985
KOiK06058
OMAiFSHAKNM
OrthoDBi600021at2759
PhylomeDBiQ23985

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-DME-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
SignaLinkiQ23985

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
31589, 0 hits in 5 CRISPR screens
EvolutionaryTraceiQ23985

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31589

Protein Ontology

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PROi
PR:Q23985

Gene expression databases

BgeeiFBgn0000524, Expressed in wing disc (Drosophila) and 40 other tissues
ExpressionAtlasiQ23985, baseline and differential
GenevisibleiQ23985, DM

Family and domain databases

CDDicd09633, Deltex_C, 1 hit
Gene3Di3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits
InterProiView protein in InterPro
IPR039396, Deltex_C
IPR039399, Deltex_C_sf
IPR039398, Deltex_fam
IPR004170, WWE-dom
IPR018123, WWE-dom_subgr
IPR037197, WWE_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR12622, PTHR12622, 1 hit
PfamiView protein in Pfam
PF18102, DTC, 1 hit
PF02825, WWE, 2 hits
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00678, WWE, 2 hits
SUPFAMiSSF117839, SSF117839, 2 hits
PROSITEiView protein in PROSITE
PS50918, WWE, 2 hits
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTX_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23985
Secondary accession number(s): A9YJA9
, A9YJB1, A9YJB7, B3LF71, Q86P53, Q9W3Z1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: October 7, 2020
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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