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Entry version 178 (12 Aug 2020)
Sequence version 3 (16 Jan 2004)
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Protein

Unconventional myosin IC

Gene

Myo61F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Functions as antagonist for Myo31DF, an unconventional myosin with an essential role in the establishment of body left-right asymmetry (PubMed:16598258, PubMed:18521948, PubMed:22491943, PubMed:25659376, PubMed:30467170).5 Publications

Miscellaneous

Overexpression in larval epidermis causes sinistral twisting of the whole larval body. Ectopic expression in tracheal precursor cells causes sinistral spiraling of tracheal branches, giving rise to a spiraling ribbon shape instead of the normal smooth tube. Ectopic expression in epithelial cells causes increased elongation and a clear shift of the membrane orientation toward one side, so that the membrane is no longer perpendicular to the anterior-posterior axis (PubMed:30467170). Overexpression causes reversal of the normal left-right laterality of the embryonic midgut and hindgut (PubMed:16598258, PubMed:18521948). Overexpression causes loss of the normal dextral rotation of the male genitalia, and leads to sinistral rotation in some cases (PubMed:22491943).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi114 – 121ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Lipid-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin IC1 Publication
Short name:
MyoIC1 Publication
Alternative name(s):
Brush border myosin IB
Short name:
BBMIB
Myosin-IB2 Publications
Short name:
MIB1 Publication
Unconventional myosin 1C2 Publications
Short name:
Myo1C2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo61F
Synonyms:Myo1C2 Publications
ORF Names:CG9155
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010246, Myo61F

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable and fertile, but adults have a shortened lifespan. Flies deficient in both Myo31DF and Myo61F are viable and fertile, but adults have a shorter lifespan than single mutants. Flies deficient in Myo61F show normal left-right asymmetry of the embryonic gut and normal, dextral rotation of male genitalia, and the same is observed in mutants deficient in both Myo61F and Myo95E. Mutants deficient in Myo31DF and Myo61F display stronger sinistral rotation of the male genitalia than mutants deficient for Myo31DF (PubMed:25659376). RNAi-mediated knockdown causes defects in embryonic midgut laterality, but only with low-frequency (PubMed:16598258). RNAi-mediated knockdown has no effect on normal, dextral rotation of male genitalia (PubMed:22491943). Combined RNAi-mediated knockdown of Myo31DF and Myo61F gives rise to the same phenotype as knockdown of Myo31DF alone, i.e sinistral rotation of the male genitalia (PubMed:22491943).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi114 – 121Missing : Abolishes the ability to cause laterality defects upon overexpression. 1 Publication8
Mutagenesisi120K → A: Abolishes the ability to cause laterality defects upon overexpression; when associated with A-166 and A-395. 1 Publication1
Mutagenesisi166N → A: Abolishes the ability to cause laterality defects upon overexpression; when associated with A-120 and A-395. 1 Publication1
Mutagenesisi395F → A: Abolishes the ability to cause laterality defects upon overexpression; when associated with A-120 and A-166. 1 Publication1
Mutagenesisi590 – 600Missing : Abolishes the ability to cause laterality defects upon overexpression. 1 PublicationAdd BLAST11
Mutagenesisi705 – 774Missing : No effect on the ability to cause laterality defects upon overexpression. 1 PublicationAdd BLAST70
Mutagenesisi775 – 1035Missing : Abolishes the ability to cause laterality defects upon overexpression. 1 PublicationAdd BLAST261

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234551 – 1035Unconventional myosin ICAdd BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei304Phosphoserine1 Publication1
Modified residuei310Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23979

PRoteomics IDEntifications database

More...
PRIDEi
Q23979

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q23979

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the embryo, expressed in gastric caeca, midgut cells of the proventriculus, and in the mid and hindgut. In the larval and adult gut brush border, expressed in the microvilli. Also expressed at high levels in follicle cells during oogenesis.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression starts at 8-12 hours embryonic development, continues to increase until third larval instar, disappears in pupae and is present at a low level in adults. Expression in embryogenesis is correlated with the formation of a brush border within the alimentary canal. In third instar larvae, detected in segment A8 of the male genital disk (PubMed:22491943). First detected at stage 12 in the embryonic anterior and posterior midgut, and in the stomatogastric nervous system. Detected in trachea at stage 14. Widely expressed in stage 16 in embryos (PubMed:25659376).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010246, Expressed in adult midgut (Drosophila) and 43 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q23979, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q23979, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds F-actin.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
63696, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q23979, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072567

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q23979

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 703Myosin motorPROSITE-ProRule annotationAdd BLAST683
Domaini696 – 728IQ 1PROSITE-ProRule annotationAdd BLAST33
Domaini729 – 751IQ 2PROSITE-ProRule annotationAdd BLAST23
Domaini752 – 779IQ 3PROSITE-ProRule annotationAdd BLAST28
Domaini857 – 1035TH1PROSITE-ProRule annotationAdd BLAST179

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni578 – 600Actin-bindingPROSITE-ProRule annotationAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The myosin motor domain contains the derminants for the direction of left-right body asymmetry.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0164, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170976

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23979

KEGG Orthology (KO)

More...
KOi
K10356

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23979

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01378, MYSc_Myo1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51757, TH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q23979-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASFNSQLKM ETGLHERDRA GVQDFVLLEN YQSEEAFIGN LKKRFQEDLI
60 70 80 90 100
YTYIGQVLIS VNPYKQLPIY TDDHVKAYRN KHFYEMPPHI FAVTDNAFRS
110 120 130 140 150
LIEENRGQCV LISGESGSGK TEASKKVLQF IAACSGNQTT VEGVKDKLLK
160 170 180 190 200
SNPVLEAFGN AKTNRNDNSS RFGKYMDIQF DFKGAPIGGN ILNYLLEKSR
210 220 230 240 250
VVAQMGGERN FHIFYQLLAG ADEALLQELR LERALDTYSY LTDGLNGTVT
260 270 280 290 300
RINDADSFKQ VQQALTVIDF TKEEQREIFG IVASILHLGN VGFTEVEGNA
310 320 330 340 350
KVNSRDLVVT AARLLGVNAS ELEAALTHRT IDARGDVVTS PLNQELAIYA
360 370 380 390 400
RDALAKAVYD RLFSWLVQRL NISLQAKETR ASRNNVMGIL DIYGFEIFQK
410 420 430 440 450
NSFEQFCINF CNEKLQQLFI ELTLKSEQDE YRREGIEWIP VEYFDNKVIC
460 470 480 490 500
NLIEEKHKGI ISILDEECLR PGEPTDKTFL EKLTQKLAQH HHYVCHEKAP
510 520 530 540 550
AHIKKIMLRD EFRLVHYAGE VTYSVNGFLD KNNDLLFRDL KETLSKAGNG
560 570 580 590 600
IVRNCFPEKE LRSLKRPETA ITQFRASLNN LMDILMCKEP SYIRCIKPND
610 620 630 640 650
LQTANVFNDE LVLHQVKYLG LMENLRVRRA GFAYRRTYEL FLERYKSLSK
660 670 680 690 700
STWPNYKGPG GPKAGVQQLV KDLGWDEEKY RVGETKLFIR WPRTLFDTED
710 720 730 740 750
AYQEKKHEIA AIIQAHWKGL MQRRKYLKLR AQVIIMQSYC RRKLAQQAAK
760 770 780 790 800
KRREAADKIR AFIKGFITRN DAPNGFNEEF IANAKRMWLL RLAKELPTKV
810 820 830 840 850
LDKSWPHAPG HCEEASGILH RLHRLHLARI YRLKLTPQQK RQFELKVLAE
860 870 880 890 900
KVFKGKKNNY ASSVSTWFQE DRIPKEHIQR VNDFVASTFG SEQLKYQSFC
910 920 930 940 950
TKFDRHGYKS RDRFILLSNK AIYVLDGKTY KQKHRLPLDK IDFTLTNHND
960 970 980 990 1000
DLMVIRIPLD LKKDKGDLIL IIPRIIEFST YIIDTVGTAS IVSIVDRNSL
1010 1020 1030
EHNVVKGKGG VIDIQTGAEP GVVRDKGHLV IIGTQ
Length:1,035
Mass (Da):118,990
Last modified:January 16, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7B153700A31D818
GO
Isoform B (identifier: Q23979-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:1,026
Mass (Da):117,982
Checksum:i77E0C20A16F0EE3E
GO
Isoform D (identifier: Q23979-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-3: AS → YIEIKSLIFAIMDTKDYID

Show »
Length:1,052
Mass (Da):121,105
Checksum:i70BCF1A49E1F2E80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73D → N in AAA19591 (PubMed:8201616).Curated1
Sequence conflicti230R → G in AAA19591 (PubMed:8201616).Curated1
Sequence conflicti251R → S in AAA19591 (PubMed:8201616).Curated1
Sequence conflicti271T → G in AAA19591 (PubMed:8201616).Curated1
Sequence conflicti554N → S in AAA19591 (PubMed:8201616).Curated1
Sequence conflicti554N → S in L13070 (PubMed:8216259).Curated1
Sequence conflicti560 – 561EL → DV in L13070 (PubMed:8216259).Curated2
Sequence conflicti610E → Y in AAL39189 (PubMed:12537569).Curated1
Sequence conflicti697D → AI in L13070 (PubMed:8216259).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0092741 – 9Missing in isoform B. 1 Publication9
Alternative sequenceiVSP_0354322 – 3AS → YIEIKSLIFAIMDTKDYID in isoform D. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U07596 mRNA Translation: AAA19591.1
AE014296 Genomic DNA Translation: AAF47477.3
AE014296 Genomic DNA Translation: AAF47478.3
AE014296 Genomic DNA Translation: AAN11472.1
AE014296 Genomic DNA Translation: AAN11473.1
AY069044 mRNA Translation: AAL39189.1
L13070 mRNA No translation available.
AJ000879 Genomic DNA Translation: CAA04367.1

Protein sequence database of the Protein Information Resource

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PIRi
S45574

NCBI Reference Sequences

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RefSeqi
NP_476934.2, NM_057586.4 [Q23979-3]
NP_728594.2, NM_167870.2 [Q23979-1]
NP_728595.1, NM_167871.2 [Q23979-2]
NP_728596.1, NM_167872.2 [Q23979-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0072672; FBpp0072565; FBgn0010246 [Q23979-2]
FBtr0072673; FBpp0072566; FBgn0010246 [Q23979-2]
FBtr0072674; FBpp0072567; FBgn0010246 [Q23979-3]
FBtr0072675; FBpp0072568; FBgn0010246 [Q23979-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
38153

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG9155

UCSC genome browser

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UCSCi
CG9155-RC, d. melanogaster
CG9155-RD, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07596 mRNA Translation: AAA19591.1
AE014296 Genomic DNA Translation: AAF47477.3
AE014296 Genomic DNA Translation: AAF47478.3
AE014296 Genomic DNA Translation: AAN11472.1
AE014296 Genomic DNA Translation: AAN11473.1
AY069044 mRNA Translation: AAL39189.1
L13070 mRNA No translation available.
AJ000879 Genomic DNA Translation: CAA04367.1
PIRiS45574
RefSeqiNP_476934.2, NM_057586.4 [Q23979-3]
NP_728594.2, NM_167870.2 [Q23979-1]
NP_728595.1, NM_167871.2 [Q23979-2]
NP_728596.1, NM_167872.2 [Q23979-2]

3D structure databases

SMRiQ23979
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63696, 9 interactors
IntActiQ23979, 9 interactors
STRINGi7227.FBpp0072567

PTM databases

iPTMnetiQ23979

Proteomic databases

PaxDbiQ23979
PRIDEiQ23979

Genome annotation databases

EnsemblMetazoaiFBtr0072672; FBpp0072565; FBgn0010246 [Q23979-2]
FBtr0072673; FBpp0072566; FBgn0010246 [Q23979-2]
FBtr0072674; FBpp0072567; FBgn0010246 [Q23979-3]
FBtr0072675; FBpp0072568; FBgn0010246 [Q23979-1]
GeneIDi38153
KEGGidme:Dmel_CG9155
UCSCiCG9155-RC, d. melanogaster
CG9155-RD, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
38153
FlyBaseiFBgn0010246, Myo61F

Phylogenomic databases

eggNOGiKOG0164, Eukaryota
GeneTreeiENSGT00940000170976
InParanoidiQ23979
KOiK10356
PhylomeDBiQ23979

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
38153, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
38153

Protein Ontology

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PROi
PR:Q23979

Gene expression databases

BgeeiFBgn0010246, Expressed in adult midgut (Drosophila) and 43 other tissues
ExpressionAtlasiQ23979, baseline and differential
GenevisibleiQ23979, DM

Family and domain databases

CDDicd01378, MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51757, TH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMY61F_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23979
Secondary accession number(s): A4V191
, Q7KVC1, Q8T0U8, Q9W0H0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 16, 2004
Last modified: August 12, 2020
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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