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Entry version 160 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Unconventional myosin ID

Gene

Myo31DF

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Generates left-right asymmetry at the level of single cells, organs and the whole body via its interaction with the actin cytoskeleton, both in the embryo and the adult (PubMed:16598258, PubMed:16598259, PubMed:18521948, PubMed:26073018, PubMed:25659376, PubMed:30467170). Normal left-right asymmetry of the larval midgut and hindgut requires expression in the embryonic hindgut epithelium during a critical time period, 10 to 12.75 hours after egg laying (PubMed:18521948). This period corresponds to a late stage of germband retraction, and precedes left-right asymmetric morphogenesis (PubMed:18521948). Expression in segment H1 of the imaginal ring is required at 0 to 24 hours after pupation for changes of cell shape and orientation in the H2 segment, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:16598258, PubMed:26073018). Required during a critical period, 126-132 hours after egg laying, for normal, dextral rotation of the adult male genitalia (PubMed:16598258, PubMed:16598259, PubMed:22491943, PubMed:26073018, PubMed:25659376). Has a double role by promoting dextral rotation in the posterior compartment of segment A8 of the male genital disk, and in repressing sinistral looping in the anterior compartment (PubMed:16598259).7 Publications

Miscellaneous

Overexpression throughout the embryo reverses the normal left-right asymmetry of the embryonic gut, giving rise to a gut that is a mirror-image of the wild-type (PubMed:16598258). Ectopic expression in the larval epidermis causes dextral twisting of the entire larval body. Ectopic expression in tracheal precursor cells causes dextral spiraling of tracheal branches, giving rise to a spiraling ribbon shape instead of the normal smooth tube. Ectopic expression in epithelial cells causes increased elongation and a clear shift of the membrane orientation toward one side, so that the membrane is no longer perpendicular to the anterior-posterior axis (PubMed:30467170).2 Publications

Caution

Represents an unconventional myosin that should not be confused with the conventional myosin-1.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi100 – 107ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • actin-dependent ATPase activity Source: UniProtKB
  • ATPase activity, coupled Source: FlyBase
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • microfilament motor activity Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Developmental protein, Motor protein, Myosin
LigandATP-binding, Lipid-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin ID2 Publications
Short name:
MyoID1 Publication
Alternative name(s):
Brush border myosin IA
Short name:
BBMIA
Myosin 1D1 Publication
Short name:
Myo1D1 Publication
Myosin-IA2 Publications
Short name:
MIA1 Publication
Short name:
MyoIA1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo31DF1 Publication
Synonyms:Myo1D1 Publication
ORF Names:CG7438
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0086347 Myo31DF

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable and fertile (PubMed:16598258). Mutant embryos and adults display normal foregut left-right asymmetry, but inverted left-right asymmetry of the midgut and hindgut (PubMed:16598258, PubMed:18521948). RNAi-mediated knockdown in the hindgut at 0 to 24 hours after pupation leads to inverted left-right asymmetry of the adult hindgut, but knockdown at later stages has little or no effect (PubMed:16598258, PubMed:26073018). Adults display inverted left-right asymmetry of the male genitalia (PubMed:16598258). RNAi-mediated knockdown in the anterior and the posterior part of segment A8 of the male genital disk causes loss of the normal dextral rotation of the genital plate and inverted, sinistral spermiduct looping (PubMed:16598259, PubMed:26073018). Selective RNAi-mediated down-regulation in the anterior part of segment A8 of the male genital disk leads to partial dextral rotation of the genitalia, while RNAi-mediated down-regulation in the posterior part of segment A8 leads to non-rotated genitalia (PubMed:16598259). Combined RNAi-mediated knockdown of both ds and Myo31DF in the H1 segment of the imaginal ring causes mislooping of the adult hindgut (PubMed:26073018).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi103 – 107Missing : Loss of function in specification of gut left-right asymmetry. 1 Publication5
Mutagenesisi106K → A: Loss of function in specification of gut left-right asymmetry; when associated with A-155 and A-382. 1 Publication1
Mutagenesisi156N → A: Loss of function in specification of gut left-right asymmetry; when associated with A-106 and A-382. 1 Publication1
Mutagenesisi331 – 1011Missing : Causes inverted left-right asymmetry of the midgut and hindgut in embryos and adults. Flies are viable and fertile, but display mildly reduced hatching rate and reduced life span. 2 PublicationsAdd BLAST681
Mutagenesisi382F → A: Loss of function in specification of gut left-right asymmetry; when associated with A-106 and A-156. 1 Publication1
Mutagenesisi579 – 589Missing : Loss of function in specification of gut left-right asymmetry. 1 PublicationAdd BLAST11
Mutagenesisi692 – 737Missing : Loss of function in specification of gut left-right asymmetry. 1 PublicationAdd BLAST46
Mutagenesisi695 – 736Missing : Loss of the ability to promote the normal dextral looping of the spermiduct. 1 PublicationAdd BLAST42
Mutagenesisi738 – 1011Missing : Loss of function in specification of gut left-right asymmetry. 1 PublicationAdd BLAST274

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234541 – 1011Unconventional myosin IDAdd BLAST1011

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23978

PRoteomics IDEntifications database

More...
PRIDEi
Q23978

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the embryo, expressed in gastric caeca, midgut cells of the proventriculus, and in the mid and hindgut. In the larval gut brush border, expression is in the terminal web domain. In the adult gut brush border, expression remains in the web domain and has also moved into the microvilli. Also expressed at low levels in follicle cells during oogenesis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically throughout development to adulthood with highest levels at the end of larval development. Expression in embryogenesis is correlated with the formation of a brush border within the alimentary canal. Detected in the developing hindgut and midgut in stage 12 and stage 14 embryos (at protein level) (PubMed:16598258). In third instar larvae, detected in a symmetrical, double chevron-like pattern in the ventral section of segment A8 of the male genital disk, with one chevron in the anterior and the other in the posterior part of this segment (PubMed:16598259, PubMed:22491943). Detected in the H1 domain of the larval imaginal disk (PubMed:26073018). Detected in embryonic anterior and posterior midgut, hindgut, and in salivary gland (PubMed:25659376).7 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0086347 Expressed in 52 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q23978 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q23978 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to F-actin (PubMed:7589814). Interacts with arm (PubMed:16598259, PubMed:22491943). Interacts with shg (PubMed:22491943). Interacts with ds (via intracellular region) (PubMed:26073018).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
60525, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q23978, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079625

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q23978

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q23978

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 690Myosin motorPROSITE-ProRule annotationAdd BLAST684
Domaini694 – 714IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini716 – 736IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini806 – 1007TH1PROSITE-ProRule annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni567 – 589Actin-bindingPROSITE-ProRule annotationAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The myosin motor domain contains the derminants for dextral twisting.1 Publication
The two IQ domains are essential for activity in determining left-right asymmetry.2 Publications
The actin-binding domain is essential for activity in determining left-right asymmetry.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0164 Eukaryota
COG5022 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158053

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q23978

KEGG Orthology (KO)

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KOi
K10356

Identification of Orthologs from Complete Genome Data

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OMAi
KQMRDYG

Database of Orthologous Groups

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OrthoDBi
122881at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q23978

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01378 MYSc_Myo1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00015 IQ, 2 hits
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q23978-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMQREAGVQ DFVLLDQVSM EKFMDNLRKR FQNGSIYTYI GEVCVSMNPY
60 70 80 90 100
RQMNIYGPET IRKYKGRELF ENAPHLFAIA DSAYRVLKQR QQDTCILISG
110 120 130 140 150
ESGAGKTEAS KIIMKYIAAV TNAQGQNEIE RVKNVLIQSN AILETFGNAK
160 170 180 190 200
TNRNDNSSRF GKYMDIEFDY KADPVGGIIT NYLLEKSRVV QQQPGERNFH
210 220 230 240 250
SFYQLLRGAN DNELRQYELQ KETGKYHYLN QGSMDILTEK SDYKGTCNAF
260 270 280 290 300
KTLGFSTDEV QTIWRTIAAV LHLGNVEFQT IEDELVISNK QHLKSTAKLL
310 320 330 340 350
QVTETELSTA LTKRVIAAGG NVMQKDHNAT QAEYGKDALA KAIYDRLFTW
360 370 380 390 400
IISRINRAIL FRGSKTQARF NSVIGVLDIY GFEIFDSNSF EQFCINYCNE
410 420 430 440 450
KLQQLFIELV LKQEQEEYQR EGIEWTNIEY FNNKIICDLV EQPHKGIIAI
460 470 480 490 500
MDEACLSVGK VTDDTLLGAM DKNLSKHPHY TSRQLKPTDK ELKHREDFRI
510 520 530 540 550
THYAGDVIYN INGFIEKNKD TLYQDFKRLL HNSKDANLSE MWPEGAQDIK
560 570 580 590 600
KTTKRPLTAG TLFQRSMADL VVTLLKKEPF YVRCIKPNDL KSSTVFDEER
610 620 630 640 650
VEHQVRYLGL LENLRVRRAG FVHRQRYDKF LLRYKMISQY TWPNFRAGSD
660 670 680 690 700
RDGVRVLIEE KKFAQDVKYG HTKIFIRSPR TLFALEHQRN EMIPHIVTLL
710 720 730 740 750
QKRVRGWIVR RNFKKMKAAI TIVRAYKAYK LRSYVQELAN RLRKAKQMRD
760 770 780 790 800
YGKSIQWPQP PLAGRKVEAK LHRMFDFWRA NMILHKYPRS EWPQLRLQII
810 820 830 840 850
AATALAGRRP YWGQARRWVG DYLANSQENS GYEAYNGSIK NIRNHPADGE
860 870 880 890 900
TFQQVLFSSF VKKFNHFNKQ ANRAFIVSDS TIHKLDGIKN KFKDMKRTIK
910 920 930 940 950
IRELTSISVS PGRDQLIVFH SSKNKDLVFS LESEYTPLKE DRIGEVVGIV
960 970 980 990 1000
CKKYHDLTGT ELRVNVTTNI SCRLDGKARI ITVEAASNVE VPNFRPKEGN
1010
IIFEVPAAYC V
Length:1,011
Mass (Da):117,095
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31206C065B5D5DFA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U07595 mRNA Translation: AAA19590.1
AE014134 Genomic DNA Translation: AAF52966.1
AE014134 Genomic DNA Translation: ADV37034.1
AE014134 Genomic DNA Translation: AAN10756.1
AY075567 mRNA Translation: AAL68374.1

Protein sequence database of the Protein Information Resource

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PIRi
S45573

NCBI Reference Sequences

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RefSeqi
NP_001188784.1, NM_001201855.2
NP_523538.1, NM_078814.4
NP_723596.1, NM_164933.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.5426

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0080035; FBpp0079625; FBgn0086347
FBtr0080036; FBpp0079626; FBgn0086347
FBtr0304138; FBpp0293078; FBgn0086347

Database of genes from NCBI RefSeq genomes

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GeneIDi
34445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7438

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07595 mRNA Translation: AAA19590.1
AE014134 Genomic DNA Translation: AAF52966.1
AE014134 Genomic DNA Translation: ADV37034.1
AE014134 Genomic DNA Translation: AAN10756.1
AY075567 mRNA Translation: AAL68374.1
PIRiS45573
RefSeqiNP_001188784.1, NM_001201855.2
NP_523538.1, NM_078814.4
NP_723596.1, NM_164933.3
UniGeneiDm.5426

3D structure databases

ProteinModelPortaliQ23978
SMRiQ23978
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60525, 9 interactors
IntActiQ23978, 7 interactors
STRINGi7227.FBpp0079625

Proteomic databases

PaxDbiQ23978
PRIDEiQ23978

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080035; FBpp0079625; FBgn0086347
FBtr0080036; FBpp0079626; FBgn0086347
FBtr0304138; FBpp0293078; FBgn0086347
GeneIDi34445
KEGGidme:Dmel_CG7438

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
34445
FlyBaseiFBgn0086347 Myo31DF

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000158053
InParanoidiQ23978
KOiK10356
OMAiKQMRDYG
OrthoDBi122881at2759
PhylomeDBiQ23978

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Myo31DF fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
34445

Protein Ontology

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PROi
PR:Q23978

Gene expression databases

BgeeiFBgn0086347 Expressed in 52 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)
ExpressionAtlasiQ23978 baseline and differential
GenevisibleiQ23978 DM

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMY31D_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23978
Secondary accession number(s): A4V0K5, M9MRS7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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