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Entry version 177 (11 Dec 2019)
Sequence version 2 (16 Aug 2005)
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Protein

Dual specificity mitogen-activated protein kinase kinase hemipterous

Gene

hep

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei226ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei320Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi203 – 211ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.12.2 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-209397 Formation of the cytosolic BSK 'scaffolding complex'
R-DME-209447 Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
R-DME-350376 Activation of RAC1:GTP by FZ:DSH complex

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q23977

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase hemipterous (EC:2.7.12.2)
Short name:
MAPKK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hep
Synonyms:hem, MKK7
ORF Names:CG4353
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010303 hep

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859921 – 1178Dual specificity mitogen-activated protein kinase kinase hemipterousAdd BLAST1178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei348PhosphoserineBy similarity1
Modified residuei352PhosphothreonineBy similarity1
Modified residuei646Phosphoserine1 Publication1
Modified residuei662Phosphoserine1 Publication1
Modified residuei1150Phosphoserine1 Publication1
Modified residuei1154Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases.By similarity
Weakly autophosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23977

PRoteomics IDEntifications database

More...
PRIDEi
Q23977

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q23977

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010303 Expressed in 30 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q23977 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q23977 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9W0K02EBI-74214,EBI-74120

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
58642, 72 interactors

Database of interacting proteins

More...
DIPi
DIP-30870N

Protein interaction database and analysis system

More...
IntActi
Q23977, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073578

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q23977

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini197 – 456Protein kinasePROSITE-ProRule annotationAdd BLAST260

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi672 – 743Thr-richAdd BLAST72
Compositional biasi768 – 815Gln-richAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0983 Eukaryota
ENOG410XTNQ LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23977

KEGG Orthology (KO)

More...
KOi
K04431

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYSHQHM

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q23977-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTIEFETIG SRLQSLEAKL QAQNESHDQI VLSGARGPVV SGSVPSARVP
60 70 80 90 100
PLATSASAAT SATHAPSLGA GSVSGSGISI AQRPAPPVPH ATPFGSASAS
110 120 130 140 150
SSSSSASAFA SAAPATGTFG GTYTPPTTRV SRATPTLPML SSGPGGGLNR
160 170 180 190 200
TRPVILPLPT PPHPPVSETD MKLKIIMEQT GKLNINGRQY PTDINDLKHL
210 220 230 240 250
GDLGNGTSGN VVKMMHLSSN TIIAVKQMRR TGNAEENKRI LMDLDVVLKS
260 270 280 290 300
HDCKYIVKCL GCFVRDPDVW ICMELMSMCF DKLLKLSKKP VPEQILGKVT
310 320 330 340 350
VATVNALSYL KDKHGVIHRD VKPSNILIDE RGNIKLCDFG ISGRLVDSKA
360 370 380 390 400
NTRSAGCAAY MAPERIDPKK PKYDIRADVW SLGITLVELA TARSPYEGCN
410 420 430 440 450
TDFEVLTKVL DSEPPCLPYG EGYNFSQQFR DFVIKCLTKN HQDRPKYPEL
460 470 480 490 500
LAQPFIRIYE SAKVDVPNWF QSIKDNRLRA NGDPTLQRAT ATGSAIGSGA
510 520 530 540 550
GSLAGSGSGS AGGAVKYGRA TTYAGQSPTN PQKTIKPTQI PSYQQQQSQF
560 570 580 590 600
FMQSATQLPQ TTTTTPTATT NCFGGSGNGN GRGNGSGGSG NGSGSSSSAS
610 620 630 640 650
PLSPPSAGIG DLNRLYRKSP FMQRKLSNGS HHPHYKYNDE SPKKESMFSS
660 670 680 690 700
IGQSILRNLT TSPFSQKKHN STATTIPLPH NNQTLITDAA TAAAAAATAT
710 720 730 740 750
TPPNIAATVL TTTPTTTPTW RLPTENSQAY DSCDSSSNAT TTTLNLGLSS
760 770 780 790 800
PSPSLPRKQF PTESPTLQLT SQQQQQPQRL QPGNQSPIVL QRFYHQQNQL
810 820 830 840 850
REKEAAERYQ QQRQQPPVGV TSTNPFHSNY VPPPPSTHST SSQSSTQSTC
860 870 880 890 900
SQIAINPASI SPSSGSGTGN MAGLGIGSAP ASGLGAAGHF GAGGTGEQLQ
910 920 930 940 950
YQPLPIAAEA TGTSPTLQSR SPEQQSDYGG NGNMVASKLS KLYARRQLLG
960 970 980 990 1000
QSSSSGASNS SLDGCSREQH DAGWFNTLAG AMKRQFATYV KTQLNSTATS
1010 1020 1030 1040 1050
PVASSMDRDQ EPVHPQPPAY RSVVNNGSGG KSYYYRTLSA ASSSSNTSQS
1060 1070 1080 1090 1100
TSPTTEPLPG GGTSSFLRRY ASSGPGGSIS TPPSPHILAG LDRRHRSPDP
1110 1120 1130 1140 1150
PPRYNRGQSP LLLRKNLLEL SGQPPGSPLL HRRYVSASPP LPPPRRGSES
1160 1170
VPGSPQHFRT RIHYTPEPQR RIYRTIDQ
Length:1,178
Mass (Da):125,108
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79A2987068EC1870
GO
Isoform C (identifier: Q23977-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     489-492: ATAT → LPNS
     493-1178: Missing.

Show »
Length:492
Mass (Da):53,132
Checksum:i6A16227A5B55F464
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PH06M9PH06_DROME
Hemipterous, isoform E
hep CG2190, D-MKK7, DHEP, DJNKK, dJNKK
492Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JJV1X2JJV1_DROME
Hemipterous, isoform F
hep CG2190, D-MKK7, DHEP, DJNKK, dJNKK
1,153Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PEF9M9PEF9_DROME
Hemipterous, isoform D
hep CG2190, D-MKK7, DHEP, DJNKK, dJNKK
1,162Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL48832 differs from that shown. Intron retention.Curated
The sequence AAL48832 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71G → S in AAC46944 (PubMed:8521475).Curated1
Sequence conflicti93 – 97PFGSA → LRSP in AAC46944 (PubMed:8521475).Curated5
Sequence conflicti106A → R in AAC46944 (PubMed:8521475).Curated1
Sequence conflicti110A → R in AAC46944 (PubMed:8521475).Curated1
Sequence conflicti118 – 121TFGG → LRW in AAC46944 (PubMed:8521475).Curated4
Sequence conflicti147 – 150GLNR → DVEC in AAC46944 (PubMed:8521475).Curated4
Sequence conflicti477 – 489RLRAN…TLQRA → DCGQWRSNAPEVT in AAC46944 (PubMed:8521475).CuratedAdd BLAST13
Sequence conflicti927D → G in AAL48832 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015107489 – 492ATAT → LPNS in isoform C. 2 Publications4
Alternative sequenceiVSP_015108493 – 1178Missing in isoform C. 2 PublicationsAdd BLAST686

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U05240 mRNA Translation: AAC46944.1
U93032 mRNA Translation: AAB63449.1
AE014298 Genomic DNA Translation: AAF48222.1
AE014298 Genomic DNA Translation: AAN09646.1
AY069695 mRNA Translation: AAL39840.1
AY071210 mRNA Translation: AAL48832.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001259501.1, NM_001272572.2 [Q23977-3]
NP_511142.2, NM_078587.3 [Q23977-3]
NP_727661.1, NM_167346.2 [Q23977-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073747; FBpp0073578; FBgn0010303 [Q23977-1]
FBtr0073748; FBpp0073579; FBgn0010303 [Q23977-3]
FBtr0330397; FBpp0303423; FBgn0010303 [Q23977-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4353

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05240 mRNA Translation: AAC46944.1
U93032 mRNA Translation: AAB63449.1
AE014298 Genomic DNA Translation: AAF48222.1
AE014298 Genomic DNA Translation: AAN09646.1
AY069695 mRNA Translation: AAL39840.1
AY071210 mRNA Translation: AAL48832.1 Sequence problems.
RefSeqiNP_001259501.1, NM_001272572.2 [Q23977-3]
NP_511142.2, NM_078587.3 [Q23977-3]
NP_727661.1, NM_167346.2 [Q23977-1]

3D structure databases

SMRiQ23977
ModBaseiSearch...

Protein-protein interaction databases

BioGridi58642, 72 interactors
DIPiDIP-30870N
IntActiQ23977, 3 interactors
STRINGi7227.FBpp0073578

PTM databases

iPTMnetiQ23977

Proteomic databases

PaxDbiQ23977
PRIDEiQ23977

Genome annotation databases

EnsemblMetazoaiFBtr0073747; FBpp0073578; FBgn0010303 [Q23977-1]
FBtr0073748; FBpp0073579; FBgn0010303 [Q23977-3]
FBtr0330397; FBpp0303423; FBgn0010303 [Q23977-3]
GeneIDi32256
KEGGidme:Dmel_CG4353

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
32256
FlyBaseiFBgn0010303 hep

Phylogenomic databases

eggNOGiKOG0983 Eukaryota
ENOG410XTNQ LUCA
InParanoidiQ23977
KOiK04431
OMAiCYSHQHM

Enzyme and pathway databases

BRENDAi2.7.12.2 1994
ReactomeiR-DME-209397 Formation of the cytosolic BSK 'scaffolding complex'
R-DME-209447 Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY
R-DME-350376 Activation of RAC1:GTP by FZ:DSH complex
SignaLinkiQ23977

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
hep fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32256

Protein Ontology

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PROi
PR:Q23977

Gene expression databases

BgeeiFBgn0010303 Expressed in 30 organ(s), highest expression level in embryo
ExpressionAtlasiQ23977 baseline and differential
GenevisibleiQ23977 DM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEP_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23977
Secondary accession number(s): O18411
, Q8SZ04, Q8SZZ1, Q9I7S3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 16, 2005
Last modified: December 11, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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