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UniProtKB - Q23919 (PGM1_DICDI)
Protein
Phosphoglucomutase-1
Gene
pgmA
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
This enzyme participates in both the breakdown and synthesis of glucose.
By similarityCatalytic activityi
- EC:5.4.2.2
Cofactori
Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 23 | SubstrateBy similarity | 1 | |
Binding sitei | 27 | SubstrateBy similarity | 1 | |
Active sitei | 120 | Phosphoserine intermediateBy similarity | 1 | |
Metal bindingi | 120 | Magnesium; via phosphate groupBy similarity | 1 | |
Binding sitei | 133 | SubstrateBy similarity | 1 | |
Metal bindingi | 288 | MagnesiumBy similarity | 1 | |
Metal bindingi | 290 | MagnesiumBy similarity | 1 | |
Metal bindingi | 292 | MagnesiumBy similarity | 1 | |
Binding sitei | 356 | SubstrateBy similarity | 1 | |
Binding sitei | 388 | SubstrateBy similarity | 1 | |
Binding sitei | 524 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- magnesium ion binding Source: InterPro
- phosphoglucomutase activity Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: GO_Central
- glucose metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DDI-3322077, Glycogen synthesis R-DDI-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphoglucomutase-1 (EC:5.4.2.2)Short name: PGM 1 Alternative name(s): Glucose phosphomutase 1 |
Gene namesi | Name:pgmA ORF Names:DDB_G0288483 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0288483, pgmA |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000147788 | 1 – 572 | Phosphoglucomutase-1Add BLAST | 572 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q23919 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 120 – 121 | Substrate bindingBy similarity | 2 | |
Regioni | 292 – 293 | Substrate bindingBy similarity | 2 | |
Regioni | 375 – 377 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the phosphohexose mutase family.Curated
Phylogenomic databases
eggNOGi | KOG0625, Eukaryota |
HOGENOMi | CLU_009330_0_1_1 |
InParanoidi | Q23919 |
OMAi | DIYKIYA |
PhylomeDBi | Q23919 |
Family and domain databases
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR005841, Alpha-D-phosphohexomutase_SF IPR045244, PGM |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit |
PRINTSi | PR00509, PGMPMM |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q23919-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFKQTFKVNI IPTQPFEGQK PGTSGLRKKV TEVMKTNYLG NFVQSIFNAL
60 70 80 90 100
PEDKLKGSTI VVGGDGRYYN NDAIQLIFQI AAANGVGKIL VGRYGLLSTP
110 120 130 140 150
AISAIVRARS ALGAIILTAS HNPGGPNGDF GIKYNMSNGG PAPESITNAI
160 170 180 190 200
YKHTTSITQI KTTRNVSVDN LGLLKTYEWN DGEFVIEVID SADDYVSLLK
210 220 230 240 250
TIFDFDGIRK FVKNHPNFTF NFDAMSGVTG AYGKRIFTDE LGIPESCLIN
260 270 280 290 300
CNPSQDFNGG HPDPNLTYAP LLVKKMNNGE FDMGCASDGD GDRNMILGKR
310 320 330 340 350
FFLNPSDSVA VIASNYKAIP YFNKGGLKGL ARSMPTSAAL ERVATDLKVP
360 370 380 390 400
FFEVPTGWKF FGNLMDAGTL SICGEESFGT GSDHIREKDG IWAIICWLQI
410 420 430 440 450
LTHHNQSTND KNFVSIEEIV KQHWAKYGRN YYSRYDYEEI DTAPAEAMMK
460 470 480 490 500
HVSQQIESKQ LIGKKFTGIS DSLEYEIASC DDFEYKDPID SSVSSHQGLR
510 520 530 540 550
IIFTDGSRII YRLSGTGSTG ATVRVYFDKY ETQPTQLNND VQTHLKSLIH
560 570
IALVEISKLN HYTGRNEPNV IT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61984 mRNA Translation: AAB03667.1 AAFI02000112 Genomic DNA Translation: EAL63190.1 |
RefSeqi | XP_636703.1, XM_631611.1 |
Genome annotation databases
EnsemblProtistsi | EAL63190; EAL63190; DDB_G0288483 |
GeneIDi | 8626660 |
KEGGi | ddi:DDB_G0288483 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61984 mRNA Translation: AAB03667.1 AAFI02000112 Genomic DNA Translation: EAL63190.1 |
RefSeqi | XP_636703.1, XM_631611.1 |
3D structure databases
AlphaFoldDBi | Q23919 |
SMRi | Q23919 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0191348 |
Proteomic databases
PaxDbi | Q23919 |
Genome annotation databases
EnsemblProtistsi | EAL63190; EAL63190; DDB_G0288483 |
GeneIDi | 8626660 |
KEGGi | ddi:DDB_G0288483 |
Organism-specific databases
dictyBasei | DDB_G0288483, pgmA |
Phylogenomic databases
eggNOGi | KOG0625, Eukaryota |
HOGENOMi | CLU_009330_0_1_1 |
InParanoidi | Q23919 |
OMAi | DIYKIYA |
PhylomeDBi | Q23919 |
Enzyme and pathway databases
Reactomei | R-DDI-3322077, Glycogen synthesis R-DDI-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q23919 |
Family and domain databases
InterProi | View protein in InterPro IPR005844, A-D-PHexomutase_a/b/a-I IPR016055, A-D-PHexomutase_a/b/a-I/II/III IPR005845, A-D-PHexomutase_a/b/a-II IPR005846, A-D-PHexomutase_a/b/a-III IPR036900, A-D-PHexomutase_C_sf IPR016066, A-D-PHexomutase_CS IPR005841, Alpha-D-phosphohexomutase_SF IPR045244, PGM |
PANTHERi | PTHR22573, PTHR22573, 1 hit |
Pfami | View protein in Pfam PF02878, PGM_PMM_I, 1 hit PF02879, PGM_PMM_II, 1 hit PF02880, PGM_PMM_III, 1 hit |
PRINTSi | PR00509, PGMPMM |
SUPFAMi | SSF53738, SSF53738, 3 hits SSF55957, SSF55957, 1 hit |
PROSITEi | View protein in PROSITE PS00710, PGM_PMM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGM1_DICDI | |
Accessioni | Q23919Primary (citable) accession number: Q23919 Secondary accession number(s): Q54IV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase - SIMILARITY comments
Index of protein domains and families