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Entry version 181 (02 Jun 2021)
Sequence version 3 (01 Jun 2003)
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Protein

Twitchin

Gene

unc-22

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces (PubMed:18390597, PubMed:7190524).

Plays a role in the organization of sarcomeres in body wall muscles (PubMed:25851606).

3 Publications

Miscellaneous

Determination of the mutation frequency of the unc-22 gene has been used to study the biological effects of short duration spaceflight.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Forces generated by the contraction/relaxation cycles of muscle activity separate the regulatory domain from the catalytic core, activating the enzyme. At rest, the kinase domain is in a closed conformation. The active site is occupied by the autoinhibitory region (CDR), which makes extensive contact with the catalytic site, blocking substrate binding. At low forces the regulatory tail will unravel reversibly and expose the active site to its substrates, potentially stabilized by binding of Ca/CALM. At high forces the kinase begins to unfold and the integrity of the active site is disrupted.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei6290ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei6382Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi6267 – 6275ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q23551

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Twitchin1 Publication (EC:2.7.11.11 Publication)
Alternative name(s):
Uncoordinated protein 221 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-22Imported
ORF Names:ZK617.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
ZK617.1a ; CE33017 ; WBGene00006759 ; unc-22
ZK617.1b ; CE33018 ; WBGene00006759 ; unc-22
ZK617.1c ; CE47057 ; WBGene00006759 ; unc-22
ZK617.1d ; CE49926 ; WBGene00006759 ; unc-22
ZK617.1e ; CE44668 ; WBGene00006759 ; unc-22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Body muscles are unable to develop or sustain normal contractions but small regions within the myofilament lattice of individual muscle cells contract transiently in the absence of contraction of the adjacent lattice (PubMed:16765996, PubMed:7190524). This results in a nearly constant body twitching phenotype (PubMed:16765996, PubMed:7190524, PubMed:25851606). Resistant to nicotine-induced paralysis (PubMed:25851606).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004046041 – 7158TwitchinAdd BLAST7158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 81PROSITE-ProRule annotation
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation
Disulfide bondi1150 ↔ 1201PROSITE-ProRule annotation
Disulfide bondi5944 ↔ 5995PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by mak-1 on the protein kinase domain and/or CDR domain in vitro.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q23551

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23551

PeptideAtlas

More...
PeptideAtlasi
Q23551

PRoteomics IDEntifications database

More...
PRIDEi
Q23551

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in body wall, anal, vulval, and pharyngeal muscles (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006759, Expressed in material anatomical entity and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q23551, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact (via protein kinase and CRD domains) with mak-1 (via protein kinase domain).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
43229, 4 interactors

STRING: functional protein association networks

More...
STRINGi
6239.ZK617.1b.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

17158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q23551

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q23551

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 97Ig-like 1Sequence analysisAdd BLAST93
Domaini111 – 204Ig-like 2Sequence analysisAdd BLAST94
Domaini377 – 466Ig-like 3Sequence analysisAdd BLAST90
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati718 – 764Kelch 1Sequence analysisAdd BLAST47
Domaini980 – 1072Ig-like 4Sequence analysisAdd BLAST93
Domaini1122 – 1213Ig-like 5Sequence analysisAdd BLAST92
Domaini1217 – 1306Ig-like 6Sequence analysisAdd BLAST90
Domaini1312 – 1398Ig-like 7Sequence analysisAdd BLAST87
Domaini1598 – 1690Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini1696 – 1791Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini1891 – 1988Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST98
Domaini1994 – 2087Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Repeati2014 – 2058Kelch 2Sequence analysisAdd BLAST45
Domaini2086 – 2181Ig-like 8Sequence analysisAdd BLAST96
Domaini2189 – 2282Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST94
Repeati2207 – 2253Kelch 3Sequence analysisAdd BLAST47
Domaini2288 – 2383Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST96
Domaini2483 – 2576Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST94
Repeati2502 – 2547Kelch 4Sequence analysisAdd BLAST46
Domaini2579 – 2675Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST97
Domaini2679 – 2763Ig-like 9Sequence analysisAdd BLAST85
Domaini2775 – 2868Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST94
Repeati2793 – 2839Kelch 5Sequence analysisAdd BLAST47
Domaini2874 – 2968Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST95
Domaini2972 – 3062Ig-like 10Sequence analysisAdd BLAST91
Domaini3070 – 3165Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST96
Repeati3089 – 3134Kelch 6Sequence analysisAdd BLAST46
Domaini3171 – 3265Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST95
Domaini3268 – 3358Ig-like 11Sequence analysisAdd BLAST91
Domaini3365 – 3459Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST95
Repeati3384 – 3430Kelch 7Sequence analysisAdd BLAST47
Domaini3465 – 3559Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST95
Domaini3563 – 3653Ig-like 12Sequence analysisAdd BLAST91
Domaini3661 – 3753Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST93
Domaini3759 – 3853Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST95
Domaini3954 – 4047Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST94
Repeati3972 – 4018Kelch 8Sequence analysisAdd BLAST47
Domaini4053 – 4146Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST94
Domaini4246 – 4340Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST95
Repeati4265 – 4310Kelch 9Sequence analysisAdd BLAST46
Domaini4346 – 4440Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST95
Repeati4365 – 4410Kelch 10Sequence analysisAdd BLAST46
Domaini4445 – 4531Ig-like 13Sequence analysisAdd BLAST87
Domaini4538 – 4631Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST94
Repeati4557 – 4602Kelch 11Sequence analysisAdd BLAST46
Domaini4637 – 4733Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST97
Domaini4739 – 4834Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST96
Domaini4936 – 5028Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST93
Domaini5034 – 5129Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST96
Domaini5231 – 5326Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST96
Repeati5287 – 5335Kelch 12Sequence analysisAdd BLAST49
Domaini5333 – 5427Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST95
Domaini5430 – 5528Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST99
Domaini5533 – 5621Ig-like 14Sequence analysisAdd BLAST89
Domaini5723 – 5817Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST95
Repeati5742 – 5787Kelch 13Sequence analysisAdd BLAST46
Domaini5823 – 5919Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST97
Domaini5923 – 6011Ig-like 15Sequence analysisAdd BLAST89
Domaini6016 – 6107Ig-like 16Sequence analysisAdd BLAST92
Domaini6114 – 6207Fibronectin type-III 31PROSITE-ProRule annotationAdd BLAST94
Domaini6261 – 6516Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini6585 – 6673Ig-like 17Sequence analysisAdd BLAST89
Domaini6696 – 6795Ig-like 18Sequence analysisAdd BLAST100
Domaini6863 – 6952Ig-like 19Sequence analysisAdd BLAST90
Domaini6958 – 7059Ig-like 20Sequence analysisAdd BLAST102
Domaini7067 – 7149Ig-like 21Sequence analysisAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni204 – 381DisorderedSequence analysisAdd BLAST178
Regioni473 – 639DisorderedSequence analysisAdd BLAST167
Regioni658 – 732DisorderedSequence analysisAdd BLAST75
Regioni763 – 955DisorderedSequence analysisAdd BLAST193
Regioni1088 – 1118DisorderedSequence analysisAdd BLAST31
Regioni2266 – 2295DisorderedSequence analysisAdd BLAST30
Regioni2849 – 2901DisorderedSequence analysisAdd BLAST53
Regioni6517 – 6581C-terminal regulatory domain (CDR)1 PublicationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi208 – 222Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi223 – 237Polar residuesSequence analysisAdd BLAST15
Compositional biasi238 – 262Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi263 – 277Polar residuesSequence analysisAdd BLAST15
Compositional biasi278 – 297Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi320 – 371Polar residuesSequence analysisAdd BLAST52
Compositional biasi473 – 504Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi516 – 530Polar residuesSequence analysisAdd BLAST15
Compositional biasi531 – 552Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi562 – 577Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi600 – 616Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi674 – 694Polar residuesSequence analysisAdd BLAST21
Compositional biasi763 – 815Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi828 – 849Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi881 – 955Basic and acidic residuesSequence analysisAdd BLAST75
Compositional biasi2269 – 2283Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2864 – 2893Basic and acidic residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0613, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169746

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23551

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYEFRVM

Database of Orthologous Groups

More...
OrthoDBi
184at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23551

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 31 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 61 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 31 hits
PF07679, I-set, 27 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 32 hits
SM00409, IG, 30 hits
SM00408, IGc2, 24 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 30 hits
SSF49265, SSF49265, 17 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 31 hits
PS50835, IG_LIKE, 21 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform b1 Publication (identifier: Q23551-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGAPRFTQK PSIQQTPTGD LLMECHLEAD PQPTIAWQHS GNLLEPSGRV
60 70 80 90 100
VQTLTPLGGS LYKATLVIKE PNAGDGGAYK CTARNQLGES NANINLNFAG
110 120 130 140 150
AGGDEAKSRG PSFVGKPRII PKDGGALIVM ECKVKSASTP VAKWMKDGVP
160 170 180 190 200
LSMGGLYHAI FSDLGDQTYL CQLEIRGPSS SDAGQYRCNI RNDQGETNAN
210 220 230 240 250
LALNFEEPDP SERQERKRST ASPRPSSRGP GSRPSSPKKS MKSREGTPKR
260 270 280 290 300
TLKPREGSPS KKLRSRTSTP VNEEVSQSES RRSSRTDKME VDQVSGASKR
310 320 330 340 350
KPDGLPPPGG DEKKLRAGSP STRKSPSRKS ASPTPSRKGS SAGGAASGTT
360 370 380 390 400
GASASATSAT SGGSASSDAS RDKYTRPPIV LEASRSQTGR IGGSVVLEVQ
410 420 430 440 450
WQCHSSTIIE WYRDGTLVRN SSEYSQSFNG SIAKLQVNKL TEEKSGLYKC
460 470 480 490 500
HAKCDYGEGQ SSAMVKIEQS DVEEELMKHR KDAEDEYQKE EQKSQTLQAE
510 520 530 540 550
TKKRVARRSK SKSKSPAPQA KKSTTSESGR QEASEVEHKR SSSVRPDPDE
560 570 580 590 600
ESQLDEIPSS GLTIPEERRR ELLGQVGESD DEVSESISEL PSFAGGKPRR
610 620 630 640 650
KTDSPPKQDD MFSRDTLLRK TTTSTKNESS TVEEKTKLRK TVKKVDGELD
660 670 680 690 700
FKAMVKLKKV KKEEGGTTEK SGFPLDHADS TSSVLSQESR SRRGSNAPFA
710 720 730 740 750
KDGLPEQPAN PFAQLKKVKS GAGGLEKSDS MASLKKLDLK KGKIDDNSDG
760 770 780 790 800
AFKVQLKKVV KKEVKESTIS VKEKNGTESG IKTEFKMEKR ERTTLQKYEK
810 820 830 840 850
TDSDGSKKED KPKKVSIAPV STNKSSDDEP STPRHHKEVE EKSTSEELKA
860 870 880 890 900
KVAGRQVGQK RNGAQKPEEP KNLLSQIQLK KVTKKAHDDT NELEGIKLKK
910 920 930 940 950
VTTVPKHVAD DDSQSESESR RGSVFGELRR GSRAPRDSAD NSRRDSIRRS
960 970 980 990 1000
SIDMRRESVQ EILEKTSTPL VPSGASGSAP KIVEVPENVT VVENETAILT
1010 1020 1030 1040 1050
CKVSGSPAPT FRWFKGSREV ISGGRFKHIT DGKEHTVALA LLKCRSQDEG
1060 1070 1080 1090 1100
PYTLTIENVH GTDSADVKLL VTSDNGLDFR AMLKHRESQA GFQKDGEGGG
1110 1120 1130 1140 1150
AGGGGGEKKP MTEAERRQSL FPGKKVEKWD IPLPEKTVQQ QVDKICEWKC
1160 1170 1180 1190 1200
TYSRPNAKIR WYKDRKEIFS GGLKYKIVIE KNVCTLIINN PEVDDTGKYT
1210 1220 1230 1240 1250
CEANGVPTHA QLTVLEPPMK YSFLNPLPNT QEIYRTKQAV LTCKVNTPRA
1260 1270 1280 1290 1300
PLVWYRGSKA IQEGDPRFII EKDAVGRCTL TIKEVEEDDQ AEWTARITQD
1310 1320 1330 1340 1350
VFSKVQVYVE EPRHTFVVPM KSQKVNESDL ATLETDVNDK DAEVVWWHDG
1360 1370 1380 1390 1400
KRIDIDGVKF KVESSNRKRR LIINGARIED HGEYKCTTKD DRTMAQLIVD
1410 1420 1430 1440 1450
AKNKFIVALK DTEVIEKDDV TLMCQTKDTK TPGIWFRNGK QISSMPGGKF
1460 1470 1480 1490 1500
ETQSRNGTHT LKIGKIEMNE ADVYEIDQAG LRGSCNVTVL EAEKRPILNW
1510 1520 1530 1540 1550
KPKKIEAKAG EPCVVKVPFQ IKGTRRGDPK AQILKNGKPI DEEMRKLVEV
1560 1570 1580 1590 1600
IIKDDVAEIV FKNPQLADTG KWALELGNSA GTALAPFELF VKDKPKPPKG
1610 1620 1630 1640 1650
PLETKNVTAE GLDLVWGTPD PDEGAPVKAY IIEMQEGRSG NWAKVGETKG
1660 1670 1680 1690 1700
TDFKVKDLKE HGEYKFRVKA LNECGLSDPL TGESVLAKNP YGVPGKPKNM
1710 1720 1730 1740 1750
DAIDVDKDHC TLAWEPPEED GGAPITGYII ERREKSEKDW HQVGQTKPDC
1760 1770 1780 1790 1800
CELTDKKVVE DKEYLYRVKA VNKAGPGDPC DHGKPIKMKA KKASPEFTGG
1810 1820 1830 1840 1850
GIKDLRLKVG ETIKYDVPIS GEPLPECLWV VNGKPLKAVG RVKMSSERGK
1860 1870 1880 1890 1900
HIMKIENAVR ADSGKFTITL KNSSGSCDST ATVTVVGRPT PPKGPLDIAD
1910 1920 1930 1940 1950
VCADGATLSW NPPDDDGGDP LTGYIVEAQD MDNKGKYIEV GKVDPNTTTL
1960 1970 1980 1990 2000
KVNGLRNKGN YKFRVKAVNN EGESEPLSAD QYTQIKDPWD EPGKPGRPEI
2010 2020 2030 2040 2050
TDFDADRIDI AWEPPHKDGG APIEEYIVEV RDPDTKEWKE VKRVPDTNAS
2060 2070 2080 2090 2100
ISGLKEGKEY QFRVRAVNKA GPGQPSEPSE KQLAKPKFIP AWLKHDNLKS
2110 2120 2130 2140 2150
ITVKAGATVR WEVKIGGEPI PEVKWFKGNQ QLENGIQLTI DTRKNEHTIL
2160 2170 2180 2190 2200
CIPSAMRSDV GEYRLTVKNS HGADEEKANL TVLDRPSKPN GPLEVSDVFE
2210 2220 2230 2240 2250
DNLNLSWKPP DDDGGEPIEY YEVEKLDTAT GRWVPCAKVK DTKAHIDGLK
2260 2270 2280 2290 2300
KGQTYQFRVK AVNKEGASDA LSTDKDTKAK NPYDEPGKTG TPDVVDWDAD
2310 2320 2330 2340 2350
RVSLEWEPPK SDGGAPITQY VIEKKGKHGR DWQECGKVSG DQTNAEILGL
2360 2370 2380 2390 2400
KEGEEYQFRV KAVNKAGPGE ASDPSRKVVA KPRNLKPWID REAMKTITIK
2410 2420 2430 2440 2450
VGNDVEFDVP VRGEPPPKKE WIFNEKPVDD QKIRIESEDY KTRFVLRGAT
2460 2470 2480 2490 2500
RKHAGLYTLT ATNASGSDKH SVEVIVLGKP SSPLGPLEVS NVYEDRADLE
2510 2520 2530 2540 2550
WKVPEDDGGA PIDHYEIEKM DLATGRWVPC GRSETTKTTV PNLQPGHEYK
2560 2570 2580 2590 2600
FRVRAVNKEG ESDPLTTNTA ILAKNPYEVP GKVDKPELVD WDKDHVDLAW
2610 2620 2630 2640 2650
NAPDDGGAPI EAFVIEKKDK NGRWEEALVV PGDQKTATVP NLKEGEEYQF
2660 2670 2680 2690 2700
RISARNKAGT GDPSDPSDRV VAKPRNLAPR IHREDLSDTT VKVGATLKFI
2710 2720 2730 2740 2750
VHIDGEPAPD VTWSFNGKGI GESKAQIENE PYISRFALPK ALRKQSGKYT
2760 2770 2780 2790 2800
ITATNINGTD SVTINIKVKS KPTKPKGPIE VTDVFEDRAT LDWKPPEDDG
2810 2820 2830 2840 2850
GEPIEFYEIE KMNTKDGIWV PCGRSGDTHF TVDSLNKGDH YKFRVKAVNS
2860 2870 2880 2890 2900
EGPSDPLETE TDILAKNPFD RPDRPGRPEP TDWDSDHVDL KWDPPLSDGG
2910 2920 2930 2940 2950
APIEEYQIEK RTKYGRWEPA ITVPGGQTTA TVPDLTPNEE YEFRVVAVNK
2960 2970 2980 2990 3000
GGPSDPSDAS KAVIAKPRNL KPHIDRDALK NLTIKAGQSI SFDVPVSGEP
3010 3020 3030 3040 3050
APTVTWHWPD NREIRNGGRV KLDNPEYQSK LVVKQMERGD SGTFTIKAVN
3060 3070 3080 3090 3100
ANGEDEATVK INVIDKPTSP NGPLDVSDVH GDHVTLNWRA PDDDGGIPIE
3110 3120 3130 3140 3150
NYVIEKYDTA SGRWVPAAKV AGDKTTAVVD GLIPGHEYKF RVAAVNAEGE
3160 3170 3180 3190 3200
SDPLETFGTT LAKDPFDKPG KTNAPEITDW DKDHVDLEWK PPANDGGAPI
3210 3220 3230 3240 3250
EEYVVEMKDE FSPFWNDVAH VPAGQTNATV GNLKEGSKYE FRIRAKNKAG
3260 3270 3280 3290 3300
LGDPSDSASA VAKARNVPPV IDRNSIQEIK VKAGQDFSLN IPVSGEPTPT
3310 3320 3330 3340 3350
ITWTFEGTPV ESDDRMKLNN EDGKTKFHVK RALRSDTGTY IIKAENENGT
3360 3370 3380 3390 3400
DTAEVKVTVL DHPSSPRGPL DVTNIVKDGC DLAWKEPEDD GGAEISHYVI
3410 3420 3430 3440 3450
EKQDAATGRW TACGESKDTN FHVDDLTQGH EYKFRVKAVN RHGDSDPLEA
3460 3470 3480 3490 3500
REAIIAKDPF DRADKPGTPE IVDWDKDHAD LKWTPPADDG GAPIEGYLVE
3510 3520 3530 3540 3550
MRTPSGDWVP AVTVGAGELT ATVDGLKPGQ TYQFRVKALN KAGESTPSDP
3560 3570 3580 3590 3600
SRTMVAKPRH LAPKINRDMF VAQRVKAGQT LNFDVNVEGE PAPKIEWFLN
3610 3620 3630 3640 3650
GSPLSSGGNT HIDNNTDNNT KLTTKSTARA DSGKYKIVAT NESGKDEHEV
3660 3670 3680 3690 3700
DVNILDIPGA PEGPLRHKDI TKESVVLKWD EPLDDGGSPI TNYVVEKQED
3710 3720 3730 3740 3750
GGRWVPCGET SDTSLKVNKL SEGHEYKFRV KAVNRQGTSA PLTSDHAIVA
3760 3770 3780 3790 3800
KNPFDEPDAP TDVTPVDWDK DHVDLEWKPP ANDGGAPIDA YIVEKKDKFG
3810 3820 3830 3840 3850
DWVECARVDG KTTKATADNL TPGETYQFRV KAVNKAGPGK PSDPTGNVVA
3860 3870 3880 3890 3900
KPRRMAPKLN LAGLLDLRIK AGTPIKLDIA FEGEPAPVAK WKANDATIDT
3910 3920 3930 3940 3950
GARADVTNTP TSSAIHIFSA VRGDTGVYKI IVENEHGKDT AQCNVTVLDV
3960 3970 3980 3990 4000
PGTPEGPLKI DEIHKEGCTL NWKPPTDNGG TDVLHYIVEK MDTSRGTWQE
4010 4020 4030 4040 4050
VGTFPDCTAK VNKLVPGKEY AFRVKAVNLQ GESKPLEAEE PIIAKNQFDV
4060 4070 4080 4090 4100
PDPVDKPEVT DWDKDRIDIK WNPTANNGGA PVTGYIVEKK EKGSAIWTEA
4110 4120 4130 4140 4150
GKTPGTTFSA DNLKPGVEYE FRVIAVNAAG PSDPSDPTDP QITKARYLKP
4160 4170 4180 4190 4200
KILTASRKIK IKAGFTHNLE VDFIGAPDPT ATWTVGDSGA ALAPELLVDA
4210 4220 4230 4240 4250
KSSTTSIFFP SAKRADSGNY KLKVKNELGE DEAIFEVIVQ DRPSAPEGPL
4260 4270 4280 4290 4300
EVSDVTKDSC VLNWKPPKDD GGAEISNYVV EKRDTKTNTW VPVSAFVTGT
4310 4320 4330 4340 4350
SITVPKLTEG HEYEFRVMAE NTFGRSDSLN TDEPVLAKDP FGTPGKPGRP
4360 4370 4380 4390 4400
EIVDTDNDHI DIKWDPPRDN GGSPVDHYDI ERKDAKTGRW IKVNTSPVQG
4410 4420 4430 4440 4450
TAFSDTRVQK GHTYEYRVVA VNKAGPGQPS DSSAAATAKP MHEAPKFDLD
4460 4470 4480 4490 4500
LDGKEFRVKA GEPLVITIPF TASPQPDISW TKEGGKPLAG VETTDSQTKL
4510 4520 4530 4540 4550
VIPSTRRSDS GPVKIKAVNP YGEAEANIKI TVIDKPGAPE NITYPAVSRH
4560 4570 4580 4590 4600
TCTLNWDAPK DDGGAEIAGY KIEYQEVGSQ IWDKVPGLIS GTAYTVRGLE
4610 4620 4630 4640 4650
HGQQYRFRIR AENAVGLSDY CQGVPVVIKD PFDPPGAPST PEITGYDTNQ
4660 4670 4680 4690 4700
VSLAWNPPRD DGGSPILGYV VERFEKRGGG DWAPVKMPMV KGTECIVPGL
4710 4720 4730 4740 4750
HENETYQFRV RAVNAAGHGE PSNGSEPVTC RPYVEKPGAP DAPRVGKITK
4760 4770 4780 4790 4800
NSAELTWNRP LRDGGAPIDG YIVEKKKLGD NDWTRCNDKP VRDTAFEVKN
4810 4820 4830 4840 4850
LGEKEEYEFR VIAVNSAGEG EPSKPSDLVL IEEQPGRPIF DINNLKDITV
4860 4870 4880 4890 4900
RAGETIQIRI PYAGGNPKPI IDLFNGNSPI FENERTVVDV NPGEIVITTT
4910 4920 4930 4940 4950
GSKRSDAGPY KISATNKYGK DTCKLNVFVL DAPGKPTGPI RATDIQADAM
4960 4970 4980 4990 5000
TLSWRPPKDN GGDAITNYVV EKRTPGGDWV TVGHPVGTTL RVRNLDANTP
5010 5020 5030 5040 5050
YEFRVRAENQ YGVGEPLETD DAIVAKNPFD TPGAPGQPEA VETSEEAITL
5060 5070 5080 5090 5100
QWTRPTSDGG APIQGYVIEK REVGSTEWTK AAFGNILDTK HRVTGLTPKK
5110 5120 5130 5140 5150
TYEFRVAAYN AAGQGEYSVN SVPITADNAP TRPKINMGML TRDILAYAGE
5160 5170 5180 5190 5200
RAKILVPFAA SPAPKVTFSK GENKISPTDP RVKVEYSDFL ATLTIEKSEL
5210 5220 5230 5240 5250
TDGGLYFVEL ENSQGSDSAS IRLKVVDKPA SPQHIRVEDI APDCCTLYWM
5260 5270 5280 5290 5300
PPSSDGGSPI TNYIVEKLDL RHSDGKWEKV SSFVRNLNYT VGGLIKDNRY
5310 5320 5330 5340 5350
RFRVRAETQY GVSEPCELAD VVVAKYQFEV PNQPEAPTVR DKDSTWAELE
5360 5370 5380 5390 5400
WDPPRDGGSK IIGYQVQYRD TSSGRWINAK MDLSEQCHAR VTGLRQNGEF
5410 5420 5430 5440 5450
EFRIIAKNAA GFSKPSPPSE RCQLKSRFGP PGPPIHVGAK SIGRNHCTIT
5460 5470 5480 5490 5500
WMAPLEDGGS KITGYNVEIR EYGSTLWTVA SDYNVREPEF TVDKLREFND
5510 5520 5530 5540 5550
YEFRVVAINA AGKGIPSLPS GPIKIQESGG SRPQIVVKPE DTAQPYNRRA
5560 5570 5580 5590 5600
VFTCEAVGRP EPTARWLRNG RELPESSRYR FEASDGVYKF TIKEVWDIDA
5610 5620 5630 5640 5650
GEYTVEVSNP YGSDTATANL VVQAPPVIEK DVPNTILPSG DLVRLKIYFS
5660 5670 5680 5690 5700
GTAPFRHSLV LNREEIDMDH PTIRIVEFDD HILITIPALS VREAGRYEYT
5710 5720 5730 5740 5750
VSNDSGEATT GFWLNVTGLP EAPQGPLHIS NIGPSTATLS WRPPVTDGGS
5760 5770 5780 5790 5800
KITSYVVEKR DLSKDEWVTV TSNVKDMNYI VTGLFENHEY EFRVSAQNEN
5810 5820 5830 5840 5850
GIGAPLVSEH PIIARLPFDP PTSPLNLEIV QVGGDYVTLS WQRPLSDGGG
5860 5870 5880 5890 5900
RLRGYIVEKQ EEEHDEWFRC NQNPSPPNNY NVPNLIDGRK YRYRVFAVND
5910 5920 5930 5940 5950
AGLSDLAELD QTLFQASGSG EGPKIVSPLS DLNEEVGRCV TFECEISGSP
5960 5970 5980 5990 6000
RPEYRWFKGC KELVDTSKYT LINKGDKQVL IINDLTSDDA DEYTCRATNS
6010 6020 6030 6040 6050
SGTRSTRANL RIKTKPRVFI PPKYHGGYEA QKGETIELKI PYKAYPQGEA
6060 6070 6080 6090 6100
RWTKDGEKIE NNSKFSITTD DKFATLRISN ASREDYGEYR VVVENSVGSD
6110 6120 6130 6140 6150
SGTVNVTVAD VPEPPRFPII ENILDEAVIL SWKPPALDGG SLVTNYTIEK
6160 6170 6180 6190 6200
REAMGGSWSP CAKSRYTYTT IEGLRAGKQY EFRIIAENKH GQSKPCEPTA
6210 6220 6230 6240 6250
PVLIPGDERK RRRGYDVDEQ GKIVRGKGTV SSNYDNYVFD IWKQYYPQPV
6260 6270 6280 6290 6300
EIKHDHVLDH YDIHEELGTG AFGVVHRVTE RATGNNFAAK FVMTPHESDK
6310 6320 6330 6340 6350
ETVRKEIQTM SVLRHPTLVN LHDAFEDDNE MVMIYEFMSG GELFEKVADE
6360 6370 6380 6390 6400
HNKMSEDEAV EYMRQVCKGL CHMHENNYVH LDLKPENIMF TTKRSNELKL
6410 6420 6430 6440 6450
IDFGLTAHLD PKQSVKVTTG TAEFAAPEVA EGKPVGYYTD MWSVGVLSYI
6460 6470 6480 6490 6500
LLSGLSPFGG ENDDETLRNV KSCDWNMDDS AFSGISEDGK DFIRKLLLAD
6510 6520 6530 6540 6550
PNTRMTIHQA LEHPWLTPGN APGRDSQIPS SRYTKIRDSI KTKYDAWPEP
6560 6570 6580 6590 6600
LPPLGRISNY SSLRKHRPQE YSIRDAFWDR SEAQPRFIVK PYGTEVGEGQ
6610 6620 6630 6640 6650
SANFYCRVIA SSPPVVTWHK DDRELKQSVK YMKRYNGNDY GLTINRVKGD
6660 6670 6680 6690 6700
DKGEYTVRAK NSYGTKEEIV FLNVTRHSEP LKFEPLEPMK KAPSPPRVEE
6710 6720 6730 6740 6750
FKERRSAPFF TFHLRNRLIQ KNHQCKLTCS LQGNPNPTIE WMKDGHPVDE
6760 6770 6780 6790 6800
DRVQVSFRSG VCSLEIFNAR VDDAGTYTVT ATNDLGVDVS ECVLTVQTKG
6810 6820 6830 6840 6850
GEPIPRVSSF RPRRAYDTLS TGTDVERSHS YADMRRRSLI RDVSPDVRSA
6860 6870 6880 6890 6900
ADDLKTKITN ELPSFTAQLS DSETEVGGSA EFSAAVSGQP EPLIEWLHNG
6910 6920 6930 6940 6950
ERISESDSRF RASYVAGKAT LRISDAKKSD EGQYLCRASN SAGQEQTRAT
6960 6970 6980 6990 7000
LTVKGDQPLL NGHAGQAVES ELRVTKHLGG EIVNNGESVT FEARVQGTPE
7010 7020 7030 7040 7050
EVLWMRNGQE LTNGDKTSIS QDGETLSFTI NSADASDAGH YQLEVRSKGT
7060 7070 7080 7090 7100
NLVSVASLVV VGEKADPPVT RLPSSVSAPL GGSTAFTIEF ENVEGLTVQW
7110 7120 7130 7140 7150
FRGSEKIEKN ERVKSVKTGN TFKLDIKNVE QDDDGIYVAK VVKEKKAIAK

YAAALLLV
Length:7,158
Mass (Da):788,953
Last modified:June 1, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i561EF9DB13387505
GO
Isoform a3 Publications (identifier: Q23551-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     604-809: Missing.
     835-947: Missing.

Show »
Length:6,839
Mass (Da):753,500
Checksum:i0C911B40FAB7C7E9
GO
Isoform c1 Publication (identifier: Q23551-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     540-550: RSSSVRPDPDE → MGQDFDSDSDS

Show »
Length:6,619
Mass (Da):730,955
Checksum:iE21C47A68CE46B4A
GO
Isoform d1 Publication (identifier: Q23551-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-809: ESQLDEIPSS...KTDSDGSKKE → NLLKKSASND...AGGKPRRKTD
     835-947: Missing.

Show »
Length:6,992
Mass (Da):769,712
Checksum:i325601B31C3A275A
GO
Isoform e1 Publication (identifier: Q23551-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     835-947: Missing.

Show »
Length:6,435
Mass (Da):710,556
Checksum:iF1CFD61E8AFE870D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2FLH2H2FLH2_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
6,927Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2FLH3H2FLH3_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
6,848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061ACT3A0A061ACT3_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
7,133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AE24A0A061AE24_CAEEL
Twitchin
unc-22 CELE_ZK617.1, ZK617.1
7,142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA33463 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0406051 – 610Missing in isoform e. 1 PublicationAdd BLAST610
Alternative sequenceiVSP_0406061 – 539Missing in isoform c. 1 PublicationAdd BLAST539
Alternative sequenceiVSP_040607540 – 550RSSSVRPDPDE → MGQDFDSDSDS in isoform c. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_040608551 – 809ESQLD…GSKKE → NLLKKSASNDGSDHGASPSS STSSSSRRLPPRPPLESSHS ASSPSSSNGGPRRMFNLRSA SDRQGASRPTGGQTPNPLNM RSANSSGQDLHKISQIHAFI LSKMPEGEAKERFLRSILDL EGPDSRRGSRDDVGSPNMLK KTNSKSSVNSSSNESQLDEI PSSGLTIPEERRRELLGQVG ESDDEVSESISELPSFAGGK PRRKTD in isoform d. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_040609604 – 809Missing in isoform a. 2 PublicationsAdd BLAST206
Alternative sequenceiVSP_040611835 – 947Missing in isoform a, isoform d and isoform e. 2 PublicationsAdd BLAST113

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X15423 Genomic DNA Translation: CAA33463.1 Sequence problems.
Z73897, Z73899 Genomic DNA Translation: CAA98064.2
Z73897, Z73899 Genomic DNA Translation: CAA98065.2
Z73897, Z73899 Genomic DNA Translation: CAM35838.2
Z73897, Z73899 Genomic DNA Translation: CBK19522.1
Z73897, Z73899 Genomic DNA Translation: CBK19523.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A88852
S57242
T27935

NCBI Reference Sequences

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RefSeqi
NP_001122835.2, NM_001129363.2 [Q23551-3]
NP_001255603.2, NM_001268674.2
NP_001255604.1, NM_001268675.1 [Q23551-5]
NP_502273.2, NM_069872.5 [Q23551-2]
NP_502274.2, NM_069873.4 [Q23551-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
ZK617.1a.1; ZK617.1a.1; WBGene00006759 [Q23551-2]
ZK617.1a.2; ZK617.1a.2; WBGene00006759 [Q23551-2]
ZK617.1a.3; ZK617.1a.3; WBGene00006759 [Q23551-2]
ZK617.1b.1; ZK617.1b.1; WBGene00006759 [Q23551-1]
ZK617.1b.2; ZK617.1b.2; WBGene00006759 [Q23551-1]
ZK617.1b.3; ZK617.1b.3; WBGene00006759 [Q23551-1]
ZK617.1c.1; ZK617.1c.1; WBGene00006759 [Q23551-3]
ZK617.1c.2; ZK617.1c.2; WBGene00006759 [Q23551-3]
ZK617.1c.3; ZK617.1c.3; WBGene00006759 [Q23551-3]
ZK617.1d.1; ZK617.1d.1; WBGene00006759
ZK617.1d.2; ZK617.1d.2; WBGene00006759
ZK617.1d.3; ZK617.1d.3; WBGene00006759
ZK617.1e.1; ZK617.1e.1; WBGene00006759 [Q23551-5]
ZK617.1e.2; ZK617.1e.2; WBGene00006759 [Q23551-5]
ZK617.1e.3; ZK617.1e.3; WBGene00006759 [Q23551-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
178135

UCSC genome browser

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UCSCi
ZK617.1a.2, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15423 Genomic DNA Translation: CAA33463.1 Sequence problems.
Z73897, Z73899 Genomic DNA Translation: CAA98064.2
Z73897, Z73899 Genomic DNA Translation: CAA98065.2
Z73897, Z73899 Genomic DNA Translation: CAM35838.2
Z73897, Z73899 Genomic DNA Translation: CBK19522.1
Z73897, Z73899 Genomic DNA Translation: CBK19523.1
PIRiA88852
S57242
T27935
RefSeqiNP_001122835.2, NM_001129363.2 [Q23551-3]
NP_001255603.2, NM_001268674.2
NP_001255604.1, NM_001268675.1 [Q23551-5]
NP_502273.2, NM_069872.5 [Q23551-2]
NP_502274.2, NM_069873.4 [Q23551-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KOAX-ray3.30A6209-6699[»]
1WITNMR-A4148-4240[»]
1WIUNMR-A4148-4240[»]
3UTOX-ray2.40A/B6108-6675[»]
SMRiQ23551
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi43229, 4 interactors
STRINGi6239.ZK617.1b.1

Proteomic databases

EPDiQ23551
PaxDbiQ23551
PeptideAtlasiQ23551
PRIDEiQ23551

Genome annotation databases

EnsemblMetazoaiZK617.1a.1; ZK617.1a.1; WBGene00006759 [Q23551-2]
ZK617.1a.2; ZK617.1a.2; WBGene00006759 [Q23551-2]
ZK617.1a.3; ZK617.1a.3; WBGene00006759 [Q23551-2]
ZK617.1b.1; ZK617.1b.1; WBGene00006759 [Q23551-1]
ZK617.1b.2; ZK617.1b.2; WBGene00006759 [Q23551-1]
ZK617.1b.3; ZK617.1b.3; WBGene00006759 [Q23551-1]
ZK617.1c.1; ZK617.1c.1; WBGene00006759 [Q23551-3]
ZK617.1c.2; ZK617.1c.2; WBGene00006759 [Q23551-3]
ZK617.1c.3; ZK617.1c.3; WBGene00006759 [Q23551-3]
ZK617.1d.1; ZK617.1d.1; WBGene00006759
ZK617.1d.2; ZK617.1d.2; WBGene00006759
ZK617.1d.3; ZK617.1d.3; WBGene00006759
ZK617.1e.1; ZK617.1e.1; WBGene00006759 [Q23551-5]
ZK617.1e.2; ZK617.1e.2; WBGene00006759 [Q23551-5]
ZK617.1e.3; ZK617.1e.3; WBGene00006759 [Q23551-5]
GeneIDi178135
UCSCiZK617.1a.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
178135
WormBaseiZK617.1a ; CE33017 ; WBGene00006759 ; unc-22
ZK617.1b ; CE33018 ; WBGene00006759 ; unc-22
ZK617.1c ; CE47057 ; WBGene00006759 ; unc-22
ZK617.1d ; CE49926 ; WBGene00006759 ; unc-22
ZK617.1e ; CE44668 ; WBGene00006759 ; unc-22

Phylogenomic databases

eggNOGiKOG0613, Eukaryota
GeneTreeiENSGT00940000169746
InParanoidiQ23551
OMAiKYEFRVM
OrthoDBi184at2759
PhylomeDBiQ23551

Enzyme and pathway databases

SignaLinkiQ23551

Miscellaneous databases

EvolutionaryTraceiQ23551

Protein Ontology

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PROi
PR:Q23551

Gene expression databases

BgeeiWBGene00006759, Expressed in material anatomical entity and 4 other tissues
ExpressionAtlasiQ23551, baseline and differential

Family and domain databases

CDDicd00063, FN3, 31 hits
Gene3Di2.60.40.10, 61 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00041, fn3, 31 hits
PF07679, I-set, 27 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 32 hits
SM00409, IG, 30 hits
SM00408, IGc2, 24 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF48726, SSF48726, 30 hits
SSF49265, SSF49265, 17 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 31 hits
PS50835, IG_LIKE, 21 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC22_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23551
Secondary accession number(s): A3RMU0
, D3YT57, D3YT58, Q23020, Q23550, Q27232, Q7JN85
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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