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Protein
Submitted name:

Leucyl Amino-acyl tRNA Synthetase

Gene

lars-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Leucyl Amino-acyl tRNA SynthetaseImported
Gene namesi
Name:lars-2Imported
ORF Names:CELE_ZK524.3Imported, ZK524.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiZK524.3a ; CE35160 ; WBGene00003074 ; lars-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ23511
PaxDbiQ23511
PeptideAtlasiQ23511

Expressioni

Gene expression databases

BgeeiWBGene00003074
ExpressionAtlasiQ23511 baseline and differential

Interactioni

Protein-protein interaction databases

DIPiDIP-24547N
IntActiQ23511, 1 interactor
STRINGi6239.ZK524.3a.1

Structurei

3D structure databases

ProteinModelPortaliQ23511
SMRiQ23511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 196tRNA-synt_1gInterPro annotationAdd BLAST137
Domaini388 – 528tRNA-synt_1InterPro annotationAdd BLAST141
Domaini701 – 743Anticodon_1InterPro annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili615 – 635Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0435 Eukaryota
COG0495 LUCA
GeneTreeiENSGT00390000015114
HOGENOMiHOG000200747
InParanoidiQ23511
KOiK01869
OMAiTFMVLAP
OrthoDBiEOG091G01P6
PhylomeDBiQ23511

Family and domain databases

Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q23511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWGTIQQI RRIGSALQWP LKDIRISENT KMLEKHWSKS LVDSFESSKN
60 70 80 90 100
KPSNLNGKKY ILSMFPYPSG RLHIGHMRVY TISDATARYY RLNGYEVIHP
110 120 130 140 150
IGWDSFGLPA ENAARDKGVD PREWTINNIE SMKQQLLKTK ILFDWEKEIS
160 170 180 190 200
TCEPEFFRWT QWIFCKLFEY GLVKRTSSEV NWDPIDKTVL AAEQIDNDGK
210 220 230 240 250
SWRSGAKAEK KKLSQWMIET PKYAKRLQEG LRKMSEQWGE VADIQANWIG
260 270 280 290 300
KCDVYRFMLP VMKDGSNDEI IDLRIKDIFE ISNAEFLVLK QSHSLADKDA
310 320 330 340 350
TQFPYKLPFQ VLNGVTGRQI PVIVVEDTYQ PDVTSFLNSR IGNFQKDKIL
360 370 380 390 400
VEKFAIAEPK HKRKLTKNDI QEMASFGGYG GYETSRTLTD WVVSRQRGWG
410 420 430 440 450
TPIPMIQTKD GKRVAVQLNK LPVLGSDRGQ EVDKERFGES GVFDTDTLDT
460 470 480 490 500
FFDSAWYYLR YLDNKNKSEL ISKGAMKNMP VDVYVGGIEH AAVHMFFARF
510 520 530 540 550
VAYFLKDINV IQTAEPFTDL IPQGIVRGKT FIEKETGKYL GSEDVQQSGD
560 570 580 590 600
KLTLKNDSSV EVDAVYEKMS KSKNNGVDLA AILDSEGVDM TRLRLLEAAA
610 620 630 640 650
PRAPINWGET DLKGIKKLLD RIAAINSQIV DARDNGKPIE LKKEIDGSIK
660 670 680 690 700
ETYNFFVRNV GMCLEVLHLH NTALMRIQGF TNALKKVDPI YLAHSPEGQR
710 720 730 740 750
AVKSLIIMLQ VFCPHVASEM WSALANDGSL VSDQKWPEVD KDADIEFLLM
760 770 780 790 800
IDGVSGGRPS LDRRIIEEMS MDQLWERATF YEHADILRMM KEDGMKLKNS
810 820 830 840 850
SYISRKGFHV TLSCSLEGDK EENRKKIGKI LDRIQAEKRK LEIGKKGGKR

KKEKKIVNK
Length:859
Mass (Da):98,278
Last modified:October 1, 2003 - v4
Checksum:iC22CB6A0B1136F01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA98144.4
PIRiB87833
T27887
RefSeqiNP_001021875.1, NM_001026704.4
UniGeneiCel.16138

Genome annotation databases

EnsemblMetazoaiZK524.3a; ZK524.3a; WBGene00003074
GeneIDi172499
KEGGicel:CELE_ZK524.3
UCSCiZK524.3b c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ23511_CAEEL
AccessioniPrimary (citable) accession number: Q23511
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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