Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

26S proteasome non-ATPase regulatory subunit 8

Gene

rpn-12

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 8
Alternative name(s):
26S proteasome regulatory subunit rpn-12
Gene namesi
Name:rpn-12
ORF Names:ZK20.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK20.5 ; CE06608 ; WBGene00004468 ; rpn-12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738481 – 25026S proteasome non-ATPase regulatory subunit 8Add BLAST250

Proteomic databases

EPDiQ23449
PaxDbiQ23449
PeptideAtlasiQ23449
PRIDEiQ23449

2D gel databases

World-2DPAGEi0020:Q23449

Expressioni

Gene expression databases

BgeeiWBGene00004468

Interactioni

Protein-protein interaction databases

BioGridi40091, 2 interactors
IntActiQ23449, 2 interactors
STRINGi6239.ZK20.5.1

Structurei

3D structure databases

ProteinModelPortaliQ23449
SMRiQ23449
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 233PCIPROSITE-ProRule annotationAdd BLAST171

Sequence similaritiesi

Belongs to the proteasome subunit S14 family.Curated

Phylogenomic databases

eggNOGiKOG3151 Eukaryota
ENOG410XXP2 LUCA
GeneTreeiENSGT00390000014682
HOGENOMiHOG000196008
InParanoidiQ23449
KOiK03031
OMAiYAGLHTR
OrthoDBiEOG091G0G73
PhylomeDBiQ23449

Family and domain databases

InterProiView protein in InterPro
IPR006746 26S_Psome_Rpn12
IPR033464 CSN8_PSD8_EIF3K
IPR000717 PCI_dom
PANTHERiPTHR12387 PTHR12387, 1 hit
PfamiView protein in Pfam
PF10075 CSN8_PSD8_EIF3K, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q23449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAHKNLLA VWAKEPKDLV AVEKALNELT KVLSASSDLN DKQSALASKD
60 70 80 90 100
LYEISVLLAI LKHDFETFDD YINQMHTYYT MAPENSENKH LMTGLHLMFL
110 120 130 140 150
LAANRLSDFH MLLEQIPQKE QTSNAYISTP VRIEQSLMEG AYNKVVLTEK
160 170 180 190 200
NIPSPFYTIF IRIMLDTIRR EIATSIEKSF KVLTAKDATV MLLFDNDEQM
210 220 230 240 250
KKFGQERKWH LDGERYVFEI EVAQEKPVNL DTVRVATQTL FYAKQLEQIV
Length:250
Mass (Da):28,795
Last modified:November 1, 1996 - v1
Checksum:i7406538A0CE1B2DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69904 Genomic DNA Translation: CAA93778.1
PIRiT27772
RefSeqiNP_496489.1, NM_064088.7
UniGeneiCel.14571

Genome annotation databases

EnsemblMetazoaiZK20.5.1; ZK20.5.1; WBGene00004468
ZK20.5.2; ZK20.5.2; WBGene00004468
GeneIDi174786
KEGGicel:CELE_ZK20.5
UCSCiZK20.5.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSMD8_CAEEL
AccessioniPrimary (citable) accession number: Q23449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health