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Entry version 135 (18 Sep 2019)
Sequence version 2 (16 Dec 2008)
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Protein
Submitted name:

Zinc finger NFX1-type containing homolog

Gene

znfx-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger NFX1-type containing homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:znfx-1Imported
ORF Names:CELE_ZK1067.2Imported, ZK1067.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
ZK1067.2a ; CE43256 ; WBGene00014208 ; znfx-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q23388

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00014208 Expressed in 4 organ(s), highest expression level in adult organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q23388 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q23388

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1538 – 1560NF-X1-typeInterPro annotationAdd BLAST23
Domaini1622 – 1642NF-X1-typeInterPro annotationAdd BLAST21
Domaini1681 – 1699NF-X1-typeInterPro annotationAdd BLAST19
Domaini1796 – 1813NF-X1-typeInterPro annotationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 108DisorderedSequence analysisAdd BLAST108
Regioni314 – 335DisorderedSequence analysisAdd BLAST22
Regioni352 – 441DisorderedSequence analysisAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1183 – 1203Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Pro-richSequence analysisAdd BLAST18
Compositional biasi19 – 46PolarSequence analysisAdd BLAST28
Compositional biasi47 – 61Pro-richSequence analysisAdd BLAST15
Compositional biasi62 – 89PolarSequence analysisAdd BLAST28
Compositional biasi90 – 108PolyampholyteSequence analysisAdd BLAST19
Compositional biasi314 – 330PolarSequence analysisAdd BLAST17
Compositional biasi352 – 410PolyampholyteSequence analysisAdd BLAST59

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1807 Eukaryota
COG1112 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160694

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000199526

Database of Orthologous Groups

More...
OrthoDBi
271662at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23388

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR027417 P-loop_NTPase
IPR000967 Znf_NFX1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086 AAA_11, 2 hits
PF13087 AAA_12, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00438 ZnF_NFX, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q23388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRNLAPPGL PPPGISISNS SPPGLSSVSP IPRADTRESR YSTPQPPGLS
60 70 80 90 100
IPAPPGISLP TPPGISLQNH QNDQFEQAHS TISRMSENSS SSRRRFRDEE
110 120 130 140 150
VQEEEGDHIL SSEDVHAARN VCETKILVRG VPQKNDSELS KLINGSKLYV
160 170 180 190 200
RFERPFVKLA HNLELLYVVN YAISSRKSIV RDHSKAIIRG LFEKDFLLKL
210 220 230 240 250
KSKFLESSFD NDTWTPEGTE LLFEIFHLFF TTARYKGGFM LTLPRFAPSW
260 270 280 290 300
HDFSMAFDIA DMDGLEEAGV GDDELRNLRR LIGYIETWIK RAERERNPSP
310 320 330 340 350
LALRSYSVYE KAGSSDSGRQ VLSESRGAGS SNVYGHDEVD FVDHRRRDEF
360 370 380 390 400
GHRDNYRTEN RRHKSPDNFG EVHRRLDEQQ QQRHEDESSR YRDDSRQSRR
410 420 430 440 450
ADDRRDQYQY NESTSMENHL GFHNGGGTVS EHSRDDKFVS PQNCEEKRKY
460 470 480 490 500
CEEDTDAKPQ QPYRFEEIKF EPIWVKCEKS EPPEDFKTLP SVPVLSEYVN
510 520 530 540 550
PVEPYLRRIQ DDGKYKSVHH YLDVQFRLLK EDLVSPLRDG IDLYKKNGTC
560 570 580 590 600
KGRRIEGAPC SDISIFNVEK VDGKQVTERD GYEMRIIWPA QYDILKLLDN
610 620 630 640 650
DREMKELGLV MLSCDRFKED FHLGHIQSSY LMRNGSLHFA VHEETSPFKP
660 670 680 690 700
NTTYQMAQGT SYLPCYKHVL ENLKRISSFK PLPFERYLVH GSKIIFRPNF
710 720 730 740 750
QQAEKSEYQI SEEKKLMKTY NELRSLAACA RYTKGKPIPR GVDDDDEDYE
760 770 780 790 800
FSKSRELSKE DIDLEYRQLQ EPIFRPLVGV DIKDSNLIQI NKKWYNVSRL
810 820 830 840 850
LDEFHPDYMD ESQRLAFCNT FKYELSLIQG PPGTGKTHIG VQIVKTILQN
860 870 880 890 900
RSYWKITEPI LVVCFTNSGL DNLLERIYQM IENDEELSKD NGRPKIIRFG
910 920 930 940 950
SKCDSNYLKR QNVMRQDVYE QYKSKVSDGA QKKMSKAGAA RRHKADNLAI
960 970 980 990 1000
SSYTLFCSRN KLLSYEMLSR VMDPNHQMEI QQFTYDHVDT KGIPLSPDEA
1010 1020 1030 1040 1050
IGCWLLERDF GKATKSQTKK AKKPKFQGAQ LDSEDENKDY FTVEDSDDEE
1060 1070 1080 1090 1100
DELDDEKLLD KLFEKMNLEC SGADILSAVH ASHADEYYTK GPWEIVQDKR
1110 1120 1130 1140 1150
PSVVVLMEKK TKPCNAKFTV DEQINNLVSE IKDMILSSQP VPKKDLNDIK
1160 1170 1180 1190 1200
YIFSLARLKR WSLYITWCDA LRSIVTENLP RQIREYREAC ENFKNAQNRV
1210 1220 1230 1240 1250
DAEIMRMTMI IGATTTGCSR LRPTLEKVGP RILIVEEAAE VLEAHIISAM
1260 1270 1280 1290 1300
ISTVEHVVMI GDHKQLRPNP AVHELGVAYG LRISMFERLV ERGLPFSQLR
1310 1320 1330 1340 1350
QQHRMNLTIS DKIVKLSFYD NVTDAENVGL YPDVQGMATN LFFWSHTSME
1360 1370 1380 1390 1400
ESPDEVSWLN KHEISMTVAL VKHLLKQNYT TNDIVVLATY SAQKNLMYRE
1410 1420 1430 1440 1450
YANVFGSTPD SNVIPVETVD SFQGKERKIV IVSLVRSHRG GRENTGIGFL
1460 1470 1480 1490 1500
AVANRICVAL TRAQHGMYII GNGAYIMNNS ELWNKIVNNL RRSNLIEYNL
1510 1520 1530 1540 1550
PLKCVAHGNI VTVKDPQDFA TKSPEGGCMQ KCDTKKFCGH VCERLCHPNM
1560 1570 1580 1590 1600
EEEHLQRCLY NCDKKCSNPQ FQHRCKKACY EECGSCLYLV EVTLDCGHRI
1610 1620 1630 1640 1650
TTPCSRINSS KCDQSCTKKL LCGHACAAKC GEECTLVSEC SQLVGMPLSC
1660 1670 1680 1690 1700
GHIKQLTCSK ISANEIDLTC DQRCEKTMLA CPHKCAEICG QPCTVECMEV
1710 1720 1730 1740 1750
VNVTLGCSHS QDVVCSSFMP GMTDHIECLT KVPKTLSPCK HTELVLCKQA
1760 1770 1780 1790 1800
PSTKLCTRRC TSYLEKCGHT CENDCGICFT TKTHICQNMC QKVLNCGHTC
1810 1820 1830 1840 1850
SAKCGESCPP CKAFCTNKCE HQSCGAGERG FGRDCSKLCA LCVNNCSNKC
1860 1870 1880 1890 1900
AHRSCTLKCF EECNVKPCTE PCTDKLKCGH ACLGICGEQC PKICGTCERN
1910 1920 1930 1940 1950
KYIECVSGTS STSRVHRLIM IPKCYHVFPV EVLDDHVKKQ KEANEKLKCP
1960 1970 1980 1990 2000
KCSAFIVGVL RYARYTKKYY LNENMRKLES NIRNIHQSTL EGRVFQAVQD
2010 2020 2030 2040 2050
SIGEIRNVTT NLTNASEDIL RNFHQKILDI RTSAETFKGK PEHKFKFASL
2060 2070 2080 2090 2100
LQVANCCLAI TRLLSVSSKF RVSRRKDIPP TFDLMSVRVL GDMPFPKLID
2110 2120 2130 2140 2150
ELNRVNIHLS NTYETFMPGA IIPKLKWLIS RMTVLQQLTS MCHQLVLEKK
2160 2170 2180 2190 2200
DIADSDAHAI NDACLNMFRY NEQHNYALNI ENFEAIVVKV APKLLEPTPK
2210
FWSWRRLQVP EL
Length:2,212
Mass (Da):252,765
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECE62DFE39EE0BC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9P860E9P860_CAEEL
Zinc finger NFX1-type containing ho...
znfx-1 CELE_ZK1067.2, ZK1067.2
2,443Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA93884.2

NCBI Reference Sequences

More...
RefSeqi
NP_001254205.1, NM_001267276.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK1067.2a.1; ZK1067.2a.1; WBGene00014208

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174463

UCSC genome browser

More...
UCSCi
ZK1067.2 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA93884.2
RefSeqiNP_001254205.1, NM_001267276.1

3D structure databases

SMRiQ23388
ModBaseiSearch...

Proteomic databases

PeptideAtlasiQ23388

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1067.2a.1; ZK1067.2a.1; WBGene00014208
GeneIDi174463
UCSCiZK1067.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174463
WormBaseiZK1067.2a ; CE43256 ; WBGene00014208 ; znfx-1

Phylogenomic databases

eggNOGiKOG1807 Eukaryota
COG1112 LUCA
GeneTreeiENSGT00940000160694
HOGENOMiHOG000199526
OrthoDBi271662at2759
PhylomeDBiQ23388

Gene expression databases

BgeeiWBGene00014208 Expressed in 4 organ(s), highest expression level in adult organism
ExpressionAtlasiQ23388 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR041679 DNA2/NAM7-like_AAA
IPR041677 DNA2/NAM7_AAA_11
IPR027417 P-loop_NTPase
IPR000967 Znf_NFX1
PfamiView protein in Pfam
PF13086 AAA_11, 2 hits
PF13087 AAA_12, 1 hit
SMARTiView protein in SMART
SM00438 ZnF_NFX, 4 hits
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ23388_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23388
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 16, 2008
Last modified: September 18, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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