Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 153 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Glutamyl-tRNA synthetase

Gene

ears-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseImportedARBA annotation, Ligase
Biological processProtein biosynthesisARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamyl-tRNA synthetaseARBA annotation (EC:6.1.1.17ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ears-1Imported
ORF Names:CELE_ZC434.5Imported, ZC434.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
ZC434.5 ; CE06580 ; WBGene00001337 ; ears-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q23315

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23315

PeptideAtlas

More...
PeptideAtlasi
Q23315

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001337, Expressed in germ line (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.ZC434.5.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini729 – 785WHEP-TRSInterPro annotationAdd BLAST57
Domaini800 – 856WHEP-TRSInterPro annotationAdd BLAST57
Domaini874 – 930WHEP-TRSInterPro annotationAdd BLAST57
Domaini941 – 997WHEP-TRSInterPro annotationAdd BLAST57
Domaini1013 – 1069WHEP-TRSInterPro annotationAdd BLAST57
Domaini1085 – 1141WHEP-TRSInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni290 – 315DisorderedSequence analysisAdd BLAST26
Regioni705 – 724DisorderedSequence analysisAdd BLAST20
Regioni774 – 798DisorderedSequence analysisAdd BLAST25
Regioni844 – 871DisorderedSequence analysisAdd BLAST28
Regioni988 – 1017DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 309PolyampholyteSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1147, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074815

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001882_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23315

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSDHKPG

Database of Orthologous Groups

More...
OrthoDBi
809861at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23315

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.240.10, 2 hits
3.40.50.620, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_02076, Glu_tRNA_synth_type2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR004526, Glu-tRNA-synth_arc/euk
IPR000924, Glu/Gln-tRNA-synth
IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059, Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056, Rbsml_L25/Gln-tRNA_synth_N
IPR011035, Ribosomal_L25/Gln-tRNA_synth
IPR014729, Rossmann-like_a/b/a_fold
IPR009068, S15_NS1_RNA-bd
IPR000738, WHEP-TRS_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00749, tRNA-synt_1c, 1 hit
PF03950, tRNA-synt_1c_C, 1 hit
PF00458, WHEP-TRS, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00987, TRNASYNTHGLU

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00991, WHEP-TRS, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47060, SSF47060, 6 hits
SSF50715, SSF50715, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00463, gltX_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit
PS51185, WHEP_TRS_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q23315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMITRELVLK ANREQPPYAS ILALAASGFS LEKSVQFSEK QQLALNLDGE
60 70 80 90 100
LLSNDVEIAR IIAQSTDAAD SLLGSSIIDF AVVDDLTNFI ADAVTKNDYS
110 120 130 140 150
LLLGKDFPTK ILDNSLTVAD FAIFSVAHNN PQLKAKFSGI IDKVLKEPTL
160 170 180 190 200
AAAHNFVGLY KSAAAPTATA STGKEKKKDE GKFVELPGAE KGKVVVRFPP
210 220 230 240 250
EASGYLHIGH AKAALLNQYY QQAFEGQLIM RFDDTNPAKE NAHFEHVIKE
260 270 280 290 300
DLSMLNIVPD RWTHSSDHFE MLLTMCEKLL KEGKAFVDDT DTETMRNERE
310 320 330 340 350
QRQDSRNRSN TPEKNLQLWE EMKKGSPKGL TCCVRMKIDM KSNNGAMRDP
360 370 380 390 400
TIYRCKPEEH VRTGLKYKVY PTYDFTCPIV DSVEGVTHAL RTTEYHDRDD
410 420 430 440 450
QYYFICDALG LRRPHIWEYA RLNMTNTVMS KRKLTWFVDE GHVEGWDDPR
460 470 480 490 500
LPTVRGVMRR GLTVEGLKQF IVAQGGSRSV VMMEWDKIWA FNKKVIDPVA
510 520 530 540 550
PRYTALDSTS PLVSIELTDS ISDDTSNVSL HPKNAEIGSK DVHKGKKLLL
560 570 580 590 600
EQVDAAALKE GEIVTFVNWG NIKIGKIEKK GAVITKISAT LQLDNTDYKK
610 620 630 640 650
TTKVTWLGDV KAEAGKTIPV VTADYDHIIS KAIIGKDEDW KQFINFDSVH
660 670 680 690 700
YTKMVGEPAI KNVKKGDIIQ IQRKGFYIVD QPYNPKSELS GVETPLLLIA
710 720 730 740 750
IPDGHTGKEA EKPPKGAPVS AAASSGGSDA LQLYNSIEQQ GGIVRDLKTK
760 770 780 790 800
DAKSQATKDA IAKLLDLKKK YKELTGSDHK PGAPPSAPAP TTPSSSESNS
810 820 830 840 850
ALNIYNLIEA QGLLVRELKG KDAKSQATKD AIAKLLELKK QYKEVSGSDH
860 870 880 890 900
KPGVPPAASV ASAPAPAPAA GSTNALDIYH QIESQGALVR ELKGKDAKSQ
910 920 930 940 950
ATKDAIAKLL ALKKQYKEVT GSDHKPGVVP VSAPAPTPLA GGADIAGQIE
960 970 980 990 1000
AQGVLVRDLK NKDSKSQETK DAIAKLLELK KNYKEVTGSD YKPGPAPAAA
1010 1020 1030 1040 1050
PAKVTVPAPS VSGGDTLSKQ IDDQALLVRE LKMKDAKSQE TKDAIAKLLQ
1060 1070 1080 1090 1100
LKKQYKDATG SDYKPAPAQL AASAAAAPAP APAFDEAALL KEIEEQGAVV
1110 1120 1130 1140
RDAKSKDPKS QDSADAINKL LALKANFKKA TGKDFPAPSN AQSKKGKKK
Length:1,149
Mass (Da):125,198
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC22744C05C0A433
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB00060.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T27567

NCBI Reference Sequences

More...
RefSeqi
NP_492711.1, NM_060310.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZC434.5.1; ZC434.5.1; WBGene00001337
ZC434.5.2; ZC434.5.2; WBGene00001337

UCSC genome browser

More...
UCSCi
ZC434.5.2, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB00060.1
PIRiT27567
RefSeqiNP_492711.1, NM_060310.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.ZC434.5.1

Proteomic databases

EPDiQ23315
PaxDbiQ23315
PeptideAtlasiQ23315

Genome annotation databases

EnsemblMetazoaiZC434.5.1; ZC434.5.1; WBGene00001337
ZC434.5.2; ZC434.5.2; WBGene00001337
UCSCiZC434.5.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172904
WormBaseiZC434.5 ; CE06580 ; WBGene00001337 ; ears-1

Phylogenomic databases

eggNOGiKOG1147, Eukaryota
GeneTreeiENSGT00550000074815
HOGENOMiCLU_001882_1_0_1
InParanoidiQ23315
OMAiGSDHKPG
OrthoDBi809861at2759
PhylomeDBiQ23315

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q23315

Gene expression databases

BgeeiWBGene00001337, Expressed in germ line (C elegans) and 5 other tissues

Family and domain databases

Gene3Di2.40.240.10, 2 hits
3.40.50.620, 1 hit
HAMAPiMF_02076, Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR004526, Glu-tRNA-synth_arc/euk
IPR000924, Glu/Gln-tRNA-synth
IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059, Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056, Rbsml_L25/Gln-tRNA_synth_N
IPR011035, Ribosomal_L25/Gln-tRNA_synth
IPR014729, Rossmann-like_a/b/a_fold
IPR009068, S15_NS1_RNA-bd
IPR000738, WHEP-TRS_dom
PfamiView protein in Pfam
PF00749, tRNA-synt_1c, 1 hit
PF03950, tRNA-synt_1c_C, 1 hit
PF00458, WHEP-TRS, 6 hits
PRINTSiPR00987, TRNASYNTHGLU
SMARTiView protein in SMART
SM00991, WHEP-TRS, 6 hits
SUPFAMiSSF47060, SSF47060, 6 hits
SSF50715, SSF50715, 1 hit
TIGRFAMsiTIGR00463, gltX_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit
PS51185, WHEP_TRS_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ23315_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23315
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again