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Entry version 144 (29 Sep 2021)
Sequence version 2 (01 Nov 1999)
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Protein

ATPase morc-1

Gene

morc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds non-specifically to DNA and forms static foci which grow by recruiting other morc-1 molecules, and thereby stimulates conformational changes and compaction of DNA, which appears to be enhanced by ATP-binding, but does not require ATP activity (PubMed:31442422).

Preferentially binds to long DNAs (PubMed:31442422).

Compacts and entraps segments of DNA by sequentially forming loops along the DNA, beginning at the free ends of single- and double-tethered DNA (PubMed:31442422).

Does not extrude the DNA loops on compacted double-tethered DNA (PubMed:31442422).

Involved in gene silencing (PubMed:22555433).

Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes (PubMed:28535375).

May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes (PubMed:28535375).

Promotes transgenerational epigenetic inheritance and germline immortality (PubMed:28535375, PubMed:28533440).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi43MagnesiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43ATPBy similarity1
Binding sitei422ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi88 – 90ATPBy similarity3
Nucleotide bindingi97 – 103ATPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processRNA-mediated gene silencing
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-75105, Fatty acyl-CoA biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATPase morc-1Curated (EC:3.6.1.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:morc-1Imported
ORF Names:ZC155.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
ZC155.3 ; CE23442 ; WBGene00022531 ; morc-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mortal germline (Mrt) phenotype in which there is a progressive decline in fertility with each generation at 25 degrees Celsius culminating in complete sterility after five to six generations (PubMed:28535375, PubMed:28533440). Resistant to nuclear RNAi and defective RNAi inheritance (PubMed:28535375). Reduced trimethylation of 'Lys-9' of histone H3 at endogenous siRNA-directed targets, a small degree of irregularly localized heterochromatin, with 70% correctly localized, defective chromatin compaction in hermaphrodite X chromosomes (PubMed:28535375). Double knockout with the histone methyltransferase met-1 rescues the progressive germline mortality defect in the morc-1 single mutant (PubMed:28535375). RNAi-mediated knockdown results in defective gene silencing (PubMed:22555433).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39E → A: Hypomorphic allele which is overexpressed relative to wild-type. Progressive germline mortality, resistant to nuclear RNAi and displays defective RNAi inheritance. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004416211 – 845ATPase morc-1CuratedAdd BLAST845

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q23243

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23243

PeptideAtlas

More...
PeptideAtlasi
Q23243

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in germline and somatic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00022531, Expressed in adult organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Predominantly forms monomers and dimers, but multimerizes to form trimers and tetramers upon DNA binding.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.ZC155.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q23243

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni566 – 590DisorderedSequence analysisAdd BLAST25
Regioni628 – 739DisorderedSequence analysisAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili284 – 311Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi570 – 590Polar residuesSequence analysisAdd BLAST21
Compositional biasi684 – 715Basic and acidic residuesSequence analysisAdd BLAST32

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1845, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153998

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_337149_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23243

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHTHIGP

Database of Orthologous Groups

More...
OrthoDBi
1399833at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23243

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036890, HATPase_C_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55874, SSF55874, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q23243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNDTNGDDY KKLEKASVNL NFLKSNSHTH IGPLSAIAEL VDNAYDADAR
60 70 80 90 100
DLHIDFLDIN NEQFLELRDD GLGMAREEAL HAITFGHSAK CSYKIGRYGN
110 120 130 140 150
GLKSGAFHLG RELLLVTKKD GIITALLISH RFHEDQGLTN SVFVPCPSFD
160 170 180 190 200
LDGIPICQTE SEKDRFNLEM KIIGKYAPLG SRTLAELADK ITGSTGTIII
210 220 230 240 250
IGNLRRSVTG ELAINTTKDP TDIIVDSGEE NKPWRESLRK YLEFIYLKPR
260 270 280 290 300
MRIHVRGEQV LPKRISENWI AKKQQLISGD QFTAAYNKIL DEKNETVKKC
310 320 330 340 350
EEEKALVMSE IGGTNYTSVR REDRANQKSL RLRVDTSQKN LDSAIADRDA
360 370 380 390 400
FKKEGKSEKS FHLNMGIETK DRSNNGIHFY INNRLILWGN KEAKFFSKFA
410 420 430 440 450
NSIGISMFLS LDYSLFSAAQ NKQGFDHVKD FQVLVRKCND ALRDYSMYLE
460 470 480 490 500
KSWIPTHLKN TWNVRIYEGD DVWAVLWGVY GYNNTTSTTC VQTHDSARDQ
510 520 530 540 550
VMWTTCGIWK LCQMCRTWIK ASRPNEIVGS NDDFFCCENV NHHGCRTIVA
560 570 580 590 600
EDNDFSKLPE KYDHILPQKR LTNSAPSSSD SQNSIRSASS CSSSSRLLNV
610 620 630 640 650
AKIESHERIH SSTGGHRLGE SFSTTSVKME PIPNNAHDSH IAEVQRRHST
660 670 680 690 700
GRAISPAVSE ISRRAGTAPS SQLDMIMGEE SDESQEALTI RAPRQRAKRP
710 720 730 740 750
IERVSRRNRR DQSDDDSDSE NEERYATAPK KSKVKGKAVV RAPKMTREKW
760 770 780 790 800
LEEMLNQFLT AHGEQPLPKN GQRDFDPTNI VEQTSRRNFK NNQRIVDAQQ
810 820 830 840
AIMRQIGSVL DHLKRNPTHN FKIPASGTVE EKLKNIEHQI KGKKK
Length:845
Mass (Da):95,793
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1896FCAE63D571EF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD66674.1

NCBI Reference Sequences

More...
RefSeqi
NP_498104.1, NM_065703.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZC155.3.1; ZC155.3.1; WBGene00022531

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175711

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZC155.3

UCSC genome browser

More...
UCSCi
ZC155.3, c. elegans

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD66674.1
RefSeqiNP_498104.1, NM_065703.5

3D structure databases

SMRiQ23243
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.ZC155.3

Proteomic databases

EPDiQ23243
PaxDbiQ23243
PeptideAtlasiQ23243

Genome annotation databases

EnsemblMetazoaiZC155.3.1; ZC155.3.1; WBGene00022531
GeneIDi175711
KEGGicel:CELE_ZC155.3
UCSCiZC155.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175711
WormBaseiZC155.3 ; CE23442 ; WBGene00022531 ; morc-1

Phylogenomic databases

eggNOGiKOG1845, Eukaryota
GeneTreeiENSGT00940000153998
HOGENOMiCLU_337149_0_0_1
InParanoidiQ23243
OMAiSHTHIGP
OrthoDBi1399833at2759
PhylomeDBiQ23243

Enzyme and pathway databases

ReactomeiR-CEL-75105, Fatty acyl-CoA biosynthesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q23243

Gene expression databases

BgeeiWBGene00022531, Expressed in adult organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036890, HATPase_C_sf
SUPFAMiSSF55874, SSF55874, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMORC1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23243
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2017
Last sequence update: November 1, 1999
Last modified: September 29, 2021
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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