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Protein

Proteasome subunit beta type-3

Gene

pbs-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-3 (EC:3.4.25.1)
Short name:
Proteasome subunit beta 3
Gene namesi
Name:pbs-3
ORF Names:Y38A8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY38A8.2 ; CE07571 ; WBGene00003949 ; pbs-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480611 – 204Proteasome subunit beta type-3Add BLAST204

Proteomic databases

EPDiQ23237
PaxDbiQ23237
PeptideAtlasiQ23237
PRIDEiQ23237

Expressioni

Gene expression databases

BgeeiWBGene00003949

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
pbs-2O621025EBI-314040,EBI-317386

Protein-protein interaction databases

BioGridi39211, 7 interactors
DIPiDIP-25063N
IntActiQ23237, 7 interactors
MINTiQ23237
STRINGi6239.Y38A8.2.2

Structurei

3D structure databases

ProteinModelPortaliQ23237
SMRiQ23237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0180 Eukaryota
ENOG410XSC8 LUCA
GeneTreeiENSGT00550000074820
HOGENOMiHOG000090523
InParanoidiQ23237
KOiK02735
OMAiEQLFGMC
OrthoDBiEOG091G0JTX
PhylomeDBiQ23237

Family and domain databases

CDDicd03759 proteasome_beta_type_3, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR033811 Proteasome_beta_3
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF62 PTHR11599:SF62, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q23237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMSYTGGT VVAMAGDECV CIASDLRIGE QMTTIATDQK KVHKVTDKVY
60 70 80 90 100
VGLAGFQSDA RTVLEKIMFR KNLYELRENR NIKPQVLSEM ISNLAYQHRF
110 120 130 140 150
GSYFTEPLVA GLDDTNKPYI CCMDTIGCVS APRDFVAVGT GQEYLLGVCE
160 170 180 190 200
NFWRENMKPD ELFEATAQSI LSCLERDAAS GWGAVVYTIT KDKVNVSTIK

ARMD
Length:204
Mass (Da):22,697
Last modified:November 1, 1996 - v1
Checksum:i323D6122149D36B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081756 Genomic DNA Translation: CCD73694.1
PIRiT26649
RefSeqiNP_494913.1, NM_062512.3
UniGeneiCel.23289

Genome annotation databases

EnsemblMetazoaiY38A8.2; Y38A8.2; WBGene00003949
GeneIDi173858
KEGGicel:CELE_Y38A8.2
UCSCiY38A8.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSB3_CAEEL
AccessioniPrimary (citable) accession number: Q23237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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