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Entry version 147 (02 Jun 2021)
Sequence version 2 (01 May 2000)
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Protein

Delta(6)-fatty-acid desaturase fat-3

Gene

fat-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can function as a Delta6 fatty acid desaturase. Introduces a double bond in the fatty acid chain 6 carbons away from carboxy terminal to biosynthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a variety of substrates such as linoleoyl-CoA ((9Z,12Z)-octadecadienoyl-CoA, C18:2n-6) and alpha-linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA, C18:3n-3) to produce gamma-linolenoyl-CoA ((6Z,9Z,12Z)-octadecatrienoyl-CoA, C18:3n-6) and (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA (18:4n-3) respectively (PubMed:9480865, PubMed:11972048).

Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity).

Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses (PubMed:18094048).

By similarity3 Publications

Miscellaneous

HPO-19 and T05H4.4 are cytochrome b5 reductases required for PUFA desaturation in Caenorhabditis elegans. HPO-19 and T05H4.4 knockdown or mutation alter FAT-3 desaturase activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.2 Publications
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2046105, Linoleic acid (LA) metabolism
R-CEL-2046106, alpha-linolenic acid (ALA) metabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00658

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000267

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta(6)-fatty-acid desaturase fat-31 Publication (EC:1.14.19.32 Publications)
Short name:
FAT-32 Publications
Alternative name(s):
Delta(6)-fatty-acid desaturase1 Publication
Short name:
Ceeld61 Publication
Fatty acid desaturase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fat-3
ORF Names:W08D2.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
W08D2.4a ; CE25153 ; WBGene00001395 ; fat-3
W08D2.4b ; CE45719 ; WBGene00001395 ; fat-3
W08D2.4c ; CE45812 ; WBGene00001395 ; fat-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

The fat-3 mutants lack detectable Delta6-unsaturated fatty acids and have decreased C20 fatty acids levels, these animals require an additional day of development before commencing egg laying (PubMed:11972048). Impaired synaptic vesicle (SV) recycling characterized by the presence of enlarged SV and the formation of abnormal endocytic membrane-bound structures at synapses. The number of SVs is reduced by 37 percent although SV production in neuron cell body and their transport to release sites are normal (PubMed:18094048).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi186S → F in wa22; Impaired synaptic vesicle recycling characterized by a partially diffused localization of synaptic vesicle protein snb-1 along the dorsal nerve cord and the formation of enlarged synaptic vesicles. snb-1 diffused localization is increased in a unc-57 (ok310) mutant background but not in a unc-26 (s1710) mutant background. Severe depletion of unc-26 at release sites in the dorsal nerve cord and increased phosphatidylinositol 4,5-bisphosphate levels at release sites and at the axonal plasma membrane. Impaired locomotion. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004233851 – 443Delta(6)-fatty-acid desaturase fat-3Add BLAST443

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q23221

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q23221

PeptideAtlas

More...
PeptideAtlasi
Q23221

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001395, Expressed in adult organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q23221, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
42924, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-27071N

Protein interaction database and analysis system

More...
IntActi
Q23221, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.W08D2.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 71Cytochrome b5 heme-bindingAdd BLAST71

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4232, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016265_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q23221

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPLLAWS

Database of Orthologous Groups

More...
OrthoDBi
1060606at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q23221

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR005804, FA_desaturase_dom
IPR012171, Fatty_acid_desaturase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00487, FA_desaturase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015921, FA_sphinglp_des, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55856, SSF55856, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform a (identifier: Q23221-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVDKNASGL RMKVDGKWLY LSEELVKKHP GGAVIEQYRN SDATHIFHAF
60 70 80 90 100
HEGSSQAYKQ LDLLKKHGEH DEFLEKQLEK RLDKVDINVS AYDVSVAQEK
110 120 130 140 150
KMVESFEKLR QKLHDDGLMK ANETYFLFKA ISTLSIMAFA FYLQYLGWYI
160 170 180 190 200
TSACLLALAW QQFGWLTHEF CHQQPTKNRP LNDTISLFFG NFLQGFSRDW
210 220 230 240 250
WKDKHNTHHA ATNVIDHDGD IDLAPLFAFI PGDLCKYKAS FEKAILKIVP
260 270 280 290 300
YQHLYFTAML PMLRFSWTGQ SVQWVFKENQ MEYKVYQRNA FWEQATIVGH
310 320 330 340 350
WAWVFYQLFL LPTWPLRVAY FIISQMGGGL LIAHVVTFNH NSVDKYPANS
360 370 380 390 400
RILNNFAALQ ILTTRNMTPS PFIDWLWGGL NYQIEHHLFP TMPRCNLNAC
410 420 430 440
MKYVKEWCKE NNLPYLVDDY FDGYAMNLQQ LKNMAEHIQA KAA
Length:443
Mass (Da):51,773
Last modified:May 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9513D611ECB99A06
GO
Isoform b (identifier: Q23221-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-258: Missing.

Show »
Length:185
Mass (Da):21,864
Checksum:iAE2D48A63FABDA29
GO
Isoform c (identifier: Q23221-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.

Show »
Length:77
Mass (Da):9,112
Checksum:i52BB59A18FC253E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
N1NTM6N1NTM6_CAEEL
FA_desaturase domain-containing pro...
fat-3 CELE_W08D2.4, W08D2.4
342Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti401M → V in AAC15586 (PubMed:9480865).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0477861 – 366Missing in isoform c. CuratedAdd BLAST366
Alternative sequenceiVSP_0477871 – 258Missing in isoform b. CuratedAdd BLAST258

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF031477 mRNA Translation: AAC15586.1
Z70271 Genomic DNA Translation: CAA94233.2
Z70271 Genomic DNA Translation: CBZ01799.1
Z70271 Genomic DNA Translation: CBZ01800.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T26280

NCBI Reference Sequences

More...
RefSeqi
NP_001255426.1, NM_001268497.1 [Q23221-1]
NP_001255427.1, NM_001268498.1 [Q23221-2]
NP_001255428.1, NM_001268499.1 [Q23221-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W08D2.4a.1; W08D2.4a.1; WBGene00001395 [Q23221-1]
W08D2.4b.1; W08D2.4b.1; WBGene00001395 [Q23221-2]
W08D2.4b.2; W08D2.4b.2; WBGene00001395 [Q23221-2]
W08D2.4c.1; W08D2.4c.1; WBGene00001395 [Q23221-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
177820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W08D2.4

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031477 mRNA Translation: AAC15586.1
Z70271 Genomic DNA Translation: CAA94233.2
Z70271 Genomic DNA Translation: CBZ01799.1
Z70271 Genomic DNA Translation: CBZ01800.1
PIRiT26280
RefSeqiNP_001255426.1, NM_001268497.1 [Q23221-1]
NP_001255427.1, NM_001268498.1 [Q23221-2]
NP_001255428.1, NM_001268499.1 [Q23221-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi42924, 1 interactor
DIPiDIP-27071N
IntActiQ23221, 1 interactor
STRINGi6239.W08D2.4a

Chemistry databases

SwissLipidsiSLP:000000267

Proteomic databases

EPDiQ23221
PaxDbiQ23221
PeptideAtlasiQ23221

Genome annotation databases

EnsemblMetazoaiW08D2.4a.1; W08D2.4a.1; WBGene00001395 [Q23221-1]
W08D2.4b.1; W08D2.4b.1; WBGene00001395 [Q23221-2]
W08D2.4b.2; W08D2.4b.2; WBGene00001395 [Q23221-2]
W08D2.4c.1; W08D2.4c.1; WBGene00001395 [Q23221-3]
GeneIDi177820
KEGGicel:CELE_W08D2.4

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
177820
WormBaseiW08D2.4a ; CE25153 ; WBGene00001395 ; fat-3
W08D2.4b ; CE45719 ; WBGene00001395 ; fat-3
W08D2.4c ; CE45812 ; WBGene00001395 ; fat-3

Phylogenomic databases

eggNOGiKOG4232, Eukaryota
GeneTreeiENSGT00950000182990
HOGENOMiCLU_016265_1_1_1
InParanoidiQ23221
OMAiMPLLAWS
OrthoDBi1060606at2759
PhylomeDBiQ23221

Enzyme and pathway databases

UniPathwayiUPA00658
ReactomeiR-CEL-2046105, Linoleic acid (LA) metabolism
R-CEL-2046106, alpha-linolenic acid (ALA) metabolism

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q23221

Gene expression databases

BgeeiWBGene00001395, Expressed in adult organism and 5 other tissues
ExpressionAtlasiQ23221, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR005804, FA_desaturase_dom
IPR012171, Fatty_acid_desaturase
PfamiView protein in Pfam
PF00487, FA_desaturase, 1 hit
PIRSFiPIRSF015921, FA_sphinglp_des, 1 hit
SUPFAMiSSF55856, SSF55856, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q23221
Secondary accession number(s): E9P867, E9P868, O61388
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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