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Entry version 53 (16 Jan 2019)
Sequence version 2 (16 Apr 2014)
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Protein
Submitted name:

REJ domain protein

Gene

TTHERM_00699790

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
REJ domain proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TTHERM_00699790Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetrahymena thermophila (strain SB210)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri312017 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009168 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini608 – 1030REJInterPro annotationAdd BLAST423

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1382 – 1402Sequence analysisAdd BLAST21
Coiled coili1447 – 1474Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22LS1

Database of Orthologous Groups

More...
OrthoDBi
883628at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002859 PKD/REJ-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02010 REJ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00261 FU, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q22LS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYVMFASQQ DVDDITKYSS NTNCLNLVDF QLYGRKYLSG DNCISDYEMT
60 70 80 90 100
IQYTPQNPKR QIYGFFFMFS FVVKFNPSTR IYPKVNINNV EQQGDFYYQI
110 120 130 140 150
EQEYSETISV VMQNFTNVVD SLNIKLTPIS IQAQYKTYIQ CQVNCDKCDY
160 170 180 190 200
NQVCLQCSSG FYYQQDTNQC VSSCNNNQFA NQQNQCQLCD NNCASCSGSS
210 220 230 240 250
SNNCLSCNPG KYYNQATNQC ICDPICKTCD GPNSNNCLSC QQGKYYNSTT
260 270 280 290 300
KQCICDLTCN TCDGPNNNDC LSCNPGKYYD QATKVCINCD PTCKTCNGPN
310 320 330 340 350
SNNCLSCQQG KYYNQTTKQC ICDPTCQTCD GPGQNNCLSC NSGLFYQQAS
360 370 380 390 400
NQCVQSFVQV VMEQVQAIVQ VASPTAFSTI KIVLVFVLMG FKCQTCYSET
410 420 430 440 450
RQMDAKSNIC VCKNQNDLRN TFYQCSYQNI ALVDATLSAT SPKLTIDFGS
460 470 480 490 500
PLINIISNSP QSLCSQIFDQ ATLGIIGLES QCEIKKNNIF VYLSDSSTIM
510 520 530 540 550
ENNSINILPN KLQFTDYSGQ FINVFYRNIT FQDPPGIPQL QFSYNHIENS
560 570 580 590 600
CNSINITLYS IQNDAGRKFM SLNWTLNQIV GSISNDQFMS LSYYFQFYIE
610 620 630 640 650
VCELGQITYF NEPIDLQLVS NQLQKQSLSQ YNQSSFQYDI LPYSLASNQT
660 670 680 690 700
FNMSLVLNLS SDNKVTAIQN ISVNVQITDL YLQIIGGSSL VLGYQNKMVL
710 720 730 740 750
NTESRDYEIQ DHNSVSNINF SWKCFSLSSI DHICYDYQDK QIQLQQGASS
760 770 780 790 800
ISFPAKTFQP YTAIQLTAFG QKDSRQSNFT TTCIFTELDI PPLKVLFSST
810 820 830 840 850
PINQKINLND DLNFQIIYGE NISSDYLSYS GAIIYDSNAV AAIKFDYFQI
860 870 880 890 900
RFRIWNYFQK IDPSKITLQI RFSVYNPLFV LPSLSTINIQ INIPPQNCVL
910 920 930 940 950
NVNPLQGISL ETIFQIQLLN CQDEDLPLTY QFFYYNSADD ANSELVSPWN
960 970 980 990 1000
ILRRQIQDQT INNSIQTILP QGNLVVMVQV MDSYLGVYNS SSIVQVQAQN
1010 1020 1030 1040 1050
KSVDEYYKLV NQLTSQSLQS SNIQITSQLV TLSIIAEDIS KNNQLSQQLN
1060 1070 1080 1090 1100
DLVGLLIQKI QQLSLQIPQF SLLSTFANKV TAQLSQLFFN SSYQNNVTIL
1110 1120 1130 1140 1150
KNKIFAYLQT ILQNTNSSIQ NSNLSHLQQN NDIQIQNMVD SFKTLNSSVS
1160 1170 1180 1190 1200
LYSNNSYEDF QSYDKISTQI GNLLNNISLP NQGQITLNGD LSTLLSDKIT
1210 1220 1230 1240 1250
QKNLFKYVIN INENSENQTS VFSITRNNYK QNIYENTSYF QAYTQKFKNI
1260 1270 1280 1290 1300
SQNFTYSKNE VISPQIYNSS SQKILNQSNI VYQFNDANSS KLYNMTCLQQ
1310 1320 1330 1340 1350
NDLSWSKQNC GISMNSQNSY MCLCASQKPT TIIEDIDDML LKNKNLQTVF
1360 1370 1380 1390 1400
GEQGLQNLAS FENFYIFLDK QTVQKRYSQI HNQELNTQLQ NEQQDQQQVD
1410 1420 1430 1440 1450
ENNQNICENS QTIKNDVFHD SPFSLQFKSN DNIQPDIQQN QQILSPIDQK
1460 1470 1480 1490 1500
RGNLNQVQEE NIEMNQQKVE SNEIQITKQQ SSCKSAEKIQ TQTQSQTQKK
1510 1520
EIQNEDEKQK INVYLQQQPQ LTAH
Length:1,524
Mass (Da):173,687
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDD6B13E45E6ACDA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG662861 Genomic DNA Translation: EAR86195.2

NCBI Reference Sequences

More...
RefSeqi
XP_976790.2, XM_971697.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAR86195; EAR86195; TTHERM_00699790

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7829124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tet:TTHERM_00699790

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662861 Genomic DNA Translation: EAR86195.2
RefSeqiXP_976790.2, XM_971697.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAR86195; EAR86195; TTHERM_00699790
GeneIDi7829124
KEGGitet:TTHERM_00699790

Phylogenomic databases

InParanoidiQ22LS1
OrthoDBi883628at2759

Family and domain databases

InterProiView protein in InterPro
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002859 PKD/REJ-like
PfamiView protein in Pfam
PF02010 REJ, 1 hit
SMARTiView protein in SMART
SM00261 FU, 5 hits
SUPFAMiSSF57184 SSF57184, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ22LS1_TETTS
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22LS1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 16, 2014
Last modified: January 16, 2019
This is version 53 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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