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Entry version 58 (22 Apr 2020)
Sequence version 2 (16 Apr 2014)
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Protein
Submitted name:

Calpain family cysteine protease

Gene

TTHERM_01347940

Organism
Tetrahymena thermophila (strain SB210)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, ProteaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calpain family cysteine proteaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TTHERM_01347940Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTetrahymena thermophila (strain SB210)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri312017 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009168 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500420096021 – 1687Sequence analysisAdd BLAST1667

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1169 – 1196Sequence analysisAdd BLAST28
Coiled coili1219 – 1239Sequence analysisAdd BLAST21
Coiled coili1666 – 1686Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_225415_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
938945at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015919 Cadherin-like_sf
IPR011044 Quino_amine_DH_bsu

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 1 hit
SSF50969 SSF50969, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q229Q1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILILAFIVN LLWLIQYINA QTAQNWVYSS QYDYIIPITE TQGLYNSIKV
60 70 80 90 100
AYKANLIFLA AGTSGVKVID PKQNYQVTSV FKSDEYVEGF SMTQDANYVF
110 120 130 140 150
IPYNKKLTIF DFSSRTQFKQ IAQDSAQIQN VDMILNNAES IVFIFQANGQ
160 170 180 190 200
IRAVNISNKQ NPTFAGSTSW HNSEIYNGFI SQDDKWLFVC QGFQGLGVYQ
210 220 230 240 250
ITYNVDGTVS FFLAGAFLGS LSGSYAVDLT SDLKYIINID NKRGVSIADF
260 270 280 290 300
TQITNAGGVY KSATYLVTIW WPTAITLPSP YSLCISKDNN FLFLGVLSQG
310 320 330 340 350
IYIVDITDKA NPNLYEVIQV FYQGKSIKLS SDESFLYYAN GQSLQIFPKT
360 370 380 390 400
SPSLNNQYLN MFNTHLATTY DWSTTYFYWR CVIDDSTKLY YGSFDDDGLW
410 420 430 440 450
IIDASVPQNM QVKVQQFKPP TSAANIDIVV FLKGFQYVII PTIDGTNVFA
460 470 480 490 500
VYATNDIITK QALATPVQLV PYQTDNYIVD SDYDETINLL IGALGNSIIF
510 520 530 540 550
LDITTVGSYF VKTVWQFTPD MKGSCTGVMF TNAFKYIIGA SRGFGYFVLD
560 570 580 590 600
ITNLQNIQMV QYINSLGAEN LFQSTISNNY GFFVDGLQGI FIVNFANLPQ
610 620 630 640 650
ISYFSQIQIL GWSNDITFVN NEKLLLVSTL EQGMVTMVDI SDIHNPFIVS
660 670 680 690 700
DYYYENQNGM STCAFEDNSY IFINNNIGVI SLPTIGQVEM HVEIAQILGY
710 720 730 740 750
SSIAQDFIFQ KMKISDIFTV GMNIQVDIVF LYQPLDLIID SIWLYQSEIM
760 770 780 790 800
YPIPTWMTYD PEAVSINIQV VKDAIDPKNM TLPLLNTILL KTLNPLYQID
810 820 830 840 850
FNYNNAACLT TSTQNQAIYN YLLANGYISD QNIVNPNLSF TAQQQLTVFP
860 870 880 890 900
SLTNSFNKCI SDMIKQTLLN SIQFAPIYLF FQTSLIYIQN PPDQLTYIKT
910 920 930 940 950
VATEVSVNVI VPKFSGQFIY ENQIGVNISI NSDKNDILIS GLIDNVNFYL
960 970 980 990 1000
SNILVLYAMN GNQYSKIQAS LVISDGINYD LSYDVLLSQI SFMKEKSPVQ
1010 1020 1030 1040 1050
KNTQLLIQSQ FNSAYASGDL QILTDFTFIF DQSTFISPDV GQVTYTAYIQ
1060 1070 1080 1090 1100
QQGQFVLLDT SHWIQYYAEG YKFYGTPPES AYEQSITIQL LGTDGYSTCS
1110 1120 1130 1140 1150
DTFVITVNQL PALFVIQWIA QVLGPIIGAL GMYKYRNIFY NAFFKHKNRY
1160 1170 1180 1190 1200
SKVNVQVNEK FILKIPLISQ DLKQAKDMIE NLIENVQKEK NGKTEKVDLQ
1210 1220 1230 1240 1250
KLAKMTTLKI DDIENNEAIK REEEDQQREA FKMQELEQNL QFYQIPNSQQ
1260 1270 1280 1290 1300
NDQDLINSNN VQTQKVTPIK HHNFNTDKND ITNQFKDKLA LTKNNPRNST
1310 1320 1330 1340 1350
LEKEYLDQDG KIKMQSITND MLKYNVKFEI VGKQLEAKAY KQELTNPDSS
1360 1370 1380 1390 1400
LYKCIKYLFS RYFIQLDKKT HLVSEYIRYF GKKNCFLHTQ NDWYKQFTKI
1410 1420 1430 1440 1450
ISEDKLDIYG QTIACPKIQL IYNNIISALI SLDLFTSKLE NFNTLSQKGV
1460 1470 1480 1490 1500
NPYLVKQVLK ADALGIDFNP PSSLFPSQGE CIHIKPSDLR SVESFKYAPG
1510 1520 1530 1540 1550
GYCFSLKKYM NMEYDPYGPK ENMQFPNWLE LIMQSGVIIL TGTPQQQDIE
1560 1570 1580 1590 1600
EILIRFYGLQ GYIYRSFTLR VQDIEGTYQK SRVESLQKQK KQADSIQGEE
1610 1620 1630 1640 1650
QSKLLNIDNQ QFDQNQFNED FNMKPIQTKN FDSEDKINQK NIRLSNFARS
1660 1670 1680
PLIENQATQI FGTPQMMDSN QKIIDLQNNI ESINLNN
Length:1,687
Mass (Da):192,650
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4104105DD811CE45
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG662542 Genomic DNA Translation: EAR82021.2

NCBI Reference Sequences

More...
RefSeqi
XP_001029684.2, XM_001029684.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAR82021; EAR82021; TTHERM_01347940

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7831695

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tet:TTHERM_01347940

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG662542 Genomic DNA Translation: EAR82021.2
RefSeqiXP_001029684.2, XM_001029684.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblProtistsiEAR82021; EAR82021; TTHERM_01347940
GeneIDi7831695
KEGGitet:TTHERM_01347940

Phylogenomic databases

HOGENOMiCLU_225415_0_0_1
OrthoDBi938945at2759

Family and domain databases

InterProiView protein in InterPro
IPR015919 Cadherin-like_sf
IPR011044 Quino_amine_DH_bsu
SUPFAMiSSF49313 SSF49313, 1 hit
SSF50969 SSF50969, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ229Q1_TETTS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q229Q1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 16, 2014
Last modified: April 22, 2020
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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