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Entry version 146 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Ammonium_transp domain-containing protein

Gene

rhr-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1237044, Erythrocytes take up carbon dioxide and release oxygen
R-CEL-1247673, Erythrocytes take up oxygen and release carbon dioxide
R-CEL-444411, Rhesus glycoproteins mediate ammonium transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.11.4.10, the ammonium transporter channel (amt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ammonium_transp domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rhr-1Imported
ORF Names:CELE_F08F3.3Imported, F08F3.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F08F3.3 ; CE09259 ; WBGene00004358 ; rhr-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 31HelicalSequence analysisAdd BLAST20
Transmembranei51 – 70HelicalSequence analysisAdd BLAST20
Transmembranei77 – 98HelicalSequence analysisAdd BLAST22
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Transmembranei144 – 166HelicalSequence analysisAdd BLAST23
Transmembranei172 – 193HelicalSequence analysisAdd BLAST22
Transmembranei205 – 224HelicalSequence analysisAdd BLAST20
Transmembranei244 – 262HelicalSequence analysisAdd BLAST19
Transmembranei274 – 293HelicalSequence analysisAdd BLAST20
Transmembranei299 – 316HelicalSequence analysisAdd BLAST18
Transmembranei337 – 354HelicalSequence analysisAdd BLAST18
Transmembranei390 – 411HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22947

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22947

PeptideAtlas

More...
PeptideAtlasi
Q22947

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004358, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-26222N

STRING: functional protein association networks

More...
STRINGi
6239.F08F3.3.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q22947

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 425Ammonium_transpInterPro annotationAdd BLAST406

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3796, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182844

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021386_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22947

Identification of Orthologs from Complete Genome Data

More...
OMAi
LFVQYET

Database of Orthologous Groups

More...
OrthoDBi
910733at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22947

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3430.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029020, Ammonium/urea_transptr
IPR024041, NH4_transpt_AmtB-like_dom
IPR002229, RhesusRHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00909, Ammonium_transp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00342, RHESUSRHD

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q22947-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSPLHQNQL TLILGLFQVV FLVIFALYGS YDASALPSET KNVEEAARMT
60 70 80 90 100
NLYPLFQDTH VMIFIGFGFL MTFLKRYGFS AVSINMLLAV FTIQWGIIVR
110 120 130 140 150
GMASAHHGFK FTISLEQLLT ADFAAAVILI SMGAMLGKLS PSQYVIMAFF
160 170 180 190 200
ETPVALIVEH ICVHNLQIND VGGSIIVHAF GAYFGLACAK GFGKKEQRGH
210 220 230 240 250
TNEGSTYHTD IFAMIGAIFL WIYWPSFNAA VAATDDARQR AVANTFLSLC
260 270 280 290 300
ACTMTTFLVS QAVDKHKRFD MVHIANSTLA GGVAIGTTAN VVLEPYHAMI
310 320 330 340 350
IGVIAGAVSV IGYKYITPFL SEKLGIHDTC GVNNLHGMPG LIAGFASIAF
360 370 380 390 400
LFIYDETRYP AQYDKIYPGM ARGEDRTRMF DEKTQALNQL MAIGLVFLAS
410 420 430 440 450
TVSGYLTGLL LKLKIWDQVR DDEYYADGDY FETPGDYDFT SRIVTSVKQI
460
EVAEYNPLSQ KEV
Length:463
Mass (Da):51,093
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09F07FFB3A04D096
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD65593.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T29442

NCBI Reference Sequences

More...
RefSeqi
NP_504436.1, NM_072035.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F08F3.3.1; F08F3.3.1; WBGene00004358
F08F3.3.2; F08F3.3.2; WBGene00004358

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178927

UCSC genome browser

More...
UCSCi
F08F3.3.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD65593.1
PIRiT29442
RefSeqiNP_504436.1, NM_072035.5

3D structure databases

SMRiQ22947
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-26222N
STRINGi6239.F08F3.3.2

Protein family/group databases

TCDBi1.A.11.4.10, the ammonium transporter channel (amt) family

Proteomic databases

EPDiQ22947
PaxDbiQ22947
PeptideAtlasiQ22947

Genome annotation databases

EnsemblMetazoaiF08F3.3.1; F08F3.3.1; WBGene00004358
F08F3.3.2; F08F3.3.2; WBGene00004358
GeneIDi178927
UCSCiF08F3.3.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178927
WormBaseiF08F3.3 ; CE09259 ; WBGene00004358 ; rhr-1

Phylogenomic databases

eggNOGiKOG3796, Eukaryota
GeneTreeiENSGT00950000182844
HOGENOMiCLU_021386_1_0_1
InParanoidiQ22947
OMAiLFVQYET
OrthoDBi910733at2759
PhylomeDBiQ22947

Enzyme and pathway databases

ReactomeiR-CEL-1237044, Erythrocytes take up carbon dioxide and release oxygen
R-CEL-1247673, Erythrocytes take up oxygen and release carbon dioxide
R-CEL-444411, Rhesus glycoproteins mediate ammonium transport

Gene expression databases

BgeeiWBGene00004358, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di1.10.3430.10, 1 hit
InterProiView protein in InterPro
IPR029020, Ammonium/urea_transptr
IPR024041, NH4_transpt_AmtB-like_dom
IPR002229, RhesusRHD
PfamiView protein in Pfam
PF00909, Ammonium_transp, 1 hit
PRINTSiPR00342, RHESUSRHD

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ22947_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22947
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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