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Entry version 150 (23 Feb 2022)
Sequence version 2 (01 Jun 2001)
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Protein

Choline kinase A2

Gene

cka-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 PublicationsNote: Mn2+ is a poor substitute (PubMed:12758145).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Ca2+. Mild inhibition by high levels of Mg2+(>10 mM) (PubMed:14960577).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.6 mM for choline (at 37 degrees Celsius and pH 10)1 Publication
  2. KM=2.4 mM for ATP (at 37 degrees Celsius and pH 10)1 Publication
  3. KM=103 µM for Mg2+ (at 37 degrees Celsius and pH 10)1 Publication
  1. Vmax=90 µmol/min/mg enzyme (at 37 degrees Celsius and pH 10)1 Publication

pH dependencei

Optimum pH is 10.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphocholine from choline.1 Publication This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphocholine from choline, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.1 Publication This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei111ATPBy similarity1
Binding sitei257ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi258CalciumCombined sources1
Binding sitei301ATPBy similarity1
Metal bindingi320CalciumCombined sources1
Metal bindingi323Calcium; via carbonyl oxygenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi82 – 88ATPBy similarity7
Nucleotide bindingi152 – 158ATPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • choline kinase activity Source: WormBase
  • ethanolamine kinase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1483191, Synthesis of PC
R-CEL-1483213, Synthesis of PE

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00558;UER00741
UPA00753;UER00737

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Choline kinase A21 Publication (EC:2.7.1.322 Publications)
Alternative name(s):
Ethanolamine kinase1 Publication (EC:2.7.1.821 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cka-2Imported
ORF Names:C52B9.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
C52B9.1a ; CE27113 ; WBGene00000510 ; cka-2
C52B9.1b ; CE38493 ; WBGene00000510 ; cka-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86S → A: Severe decrease in catalytic efficiency. 1 Publication1
Mutagenesisi111R → A: 10-fold reduction in catalytic efficiency for ATP. 1 Publication1
Mutagenesisi125E → A: Moderate decrease in catalytic efficiency with a 3-fold decrease in the affinity for ATP and for Mg(2+). Activated by low concentrations of Ca(2+) and inhibited by high concentrations of Ca(2+). 1 Publication1
Mutagenesisi253H → A: Linear activity for only a short time, suggesting a role in maintaining enzyme conformation. 1 Publication1
Mutagenesisi254N → A: Linear activity for only a short time, suggesting a role in maintaining enzyme conformation. 1 Publication1
Mutagenesisi255D → A or N: Complete loss of activity. 1 Publication1
Mutagenesisi255D → E: Severe decrease in catalytic efficiency with a 5-fold decrease in the affinity for choline. 1 Publication1
Mutagenesisi260N → A: Severe decrease in catalytic efficiency with a 3-fold decrease in the affinity for ATP and for Mg(2+). No inhibition at high Mg(2+) concentrations. Activated by low concentrations of Ca(2+) and inhibited by high concentrations of Ca(2+). 1 Publication1
Mutagenesisi301D → A, E or N: Complete loss of activity. 1 Publication1
Mutagenesisi303E → A: Severe decrease in catalytic efficiency with a decreased affinity for Mg(2+). No inhibition at high Mg(2+) concentrations. Activated by low concentrations of Ca(2+) and inhibited by high concentrations of Ca(2+). 1 Publication1
Mutagenesisi303E → N or Q: Moderate decrease in catalytic efficiency. 1 Publication1
Mutagenesisi320E → A: Linear activity for only a short time, suggesting a role in maintaining enzyme conformation. Substantial decrease in the affinity for ATP. 1 Publication1
Mutagenesisi387W → A: Severe decrease in catalytic efficiency but no effect on the affinity for ATP and choline. No inhibition at high Mg(2+) concentrations. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004320711 – 429Choline kinase A2Add BLAST429

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22942

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22942

PeptideAtlas

More...
PeptideAtlasi
Q22942

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000510, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:12791258, PubMed:12758145). A small proportion exists as higher oligomers (PubMed:12758145).

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C52B9.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1429
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q22942

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q22942

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 86Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2686, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182939

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22942

Identification of Orthologs from Complete Genome Data

More...
OMAi
LKERAHM

Database of Orthologous Groups

More...
OrthoDBi
1469912at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22942

Family and domain databases

Database of protein disorder

More...
DisProti
DP02987

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q22942-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSRKVSRAH YDEDELASAA NMSLVAEGHF RGMKELLSTM DLDTDANTIP
60 70 80 90 100
ELKERAHMLC ARFLGGAWKT VPLEHLRISR IKGGMSNMLF LCRLSEVYPP
110 120 130 140 150
IRNEPNKVLL RVYFNPETES HLVAESVIFT LLSERHLGPK LYGIFSGGRL
160 170 180 190 200
EEYIPSRPLS CHEISLAHMS TKIAKRVAKV HQLEVPIWKE PDYLCEALQR
210 220 230 240 250
WLKQLTGTVD AEHRFDLPEE CGVSSVNCLD LARELEFLRA HISLSKSPVT
260 270 280 290 300
FCHNDLQEGN ILLPKASSGN IRMPSLSDET QALGNSLSAF NPADPRLVLI
310 320 330 340 350
DFEYASYNYR AFDFANHFIE WTIDYDIDEA PFYKIQTENF PENDQMLEFF
360 370 380 390 400
LNYLREQGNT RENELYKKSE DLVQETLPFV PVSHFFWGVW GLLQVELSPV
410 420
GFGFADYGRD RLSLYFKHKQ LLKNLASHQ
Length:429
Mass (Da):49,240
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB536F35871DCEFD1
GO
Isoform bImported (identifier: Q22942-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:408
Mass (Da):46,921
Checksum:i00FA275E2421B2DA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0574741 – 21Missing in isoform b. CuratedAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080644 Genomic DNA Translation: CCD65407.1
FO080644 Genomic DNA Translation: CCD65408.1

NCBI Reference Sequences

More...
RefSeqi
NP_001024480.1, NM_001029309.4 [Q22942-1]
NP_001024481.1, NM_001029310.3 [Q22942-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C52B9.1a.1; C52B9.1a.1; WBGene00000510 [Q22942-1]
C52B9.1b.1; C52B9.1b.1; WBGene00000510 [Q22942-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180703

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C52B9.1

UCSC genome browser

More...
UCSCi
C52B9.1a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080644 Genomic DNA Translation: CCD65407.1
FO080644 Genomic DNA Translation: CCD65408.1
RefSeqiNP_001024480.1, NM_001029309.4 [Q22942-1]
NP_001024481.1, NM_001029310.3 [Q22942-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NW1X-ray2.02A/B1-429[»]
SMRiQ22942
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi6239.C52B9.1a

Proteomic databases

EPDiQ22942
PaxDbiQ22942
PeptideAtlasiQ22942

Genome annotation databases

EnsemblMetazoaiC52B9.1a.1; C52B9.1a.1; WBGene00000510 [Q22942-1]
C52B9.1b.1; C52B9.1b.1; WBGene00000510 [Q22942-2]
GeneIDi180703
KEGGicel:CELE_C52B9.1
UCSCiC52B9.1a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180703
WormBaseiC52B9.1a ; CE27113 ; WBGene00000510 ; cka-2
C52B9.1b ; CE38493 ; WBGene00000510 ; cka-2

Phylogenomic databases

eggNOGiKOG2686, Eukaryota
GeneTreeiENSGT00950000182939
InParanoidiQ22942
OMAiLKERAHM
OrthoDBi1469912at2759
PhylomeDBiQ22942

Enzyme and pathway databases

UniPathwayiUPA00558;UER00741
UPA00753;UER00737
ReactomeiR-CEL-1483191, Synthesis of PC
R-CEL-1483213, Synthesis of PE

Miscellaneous databases

EvolutionaryTraceiQ22942

Protein Ontology

More...
PROi
PR:Q22942

Gene expression databases

BgeeiWBGene00000510, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

Family and domain databases

DisProtiDP02987
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
SUPFAMiSSF56112, SSF56112, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCKA2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22942
Secondary accession number(s): Q2XN11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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