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Entry version 130 (05 Jun 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Tropomyosin isoforms a/b/d/f

Gene

lev-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction (PubMed:9113409, PubMed:11901171). Involved in muscle actin filament organization and muscle arm extension and morphology (PubMed:15930100). Protects actin filaments from depolymerization by unc-60 in vitro (PubMed:17684058). Also has a role in male mating behavior by regulating the copulatory spicules (PubMed:16399684). Binds to F-actin (PubMed:11901171).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-445355 Smooth Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tropomyosin isoforms a/b/d/f
Alternative name(s):
Levamisole resistant protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lev-11
Synonyms:tmy-1
ORF Names:Y105E8B.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
Y105E8B.1a ; CE28782 ; WBGene00002978 ; lev-11
Y105E8B.1b ; CE36223 ; WBGene00002978 ; lev-11
Y105E8B.1d ; CE29060 ; WBGene00002978 ; lev-11
Y105E8B.1f ; CE36224 ; WBGene00002978 ; lev-11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms have 50-75% embryonic lethality (PubMed:15930100). Those that survive body wall interference have abnormal body morphology and uncoordinated movements, and those that survive pharynx interference have deformed pharynges and gut regions (PubMed:15930100). RNAi-mediated knockdown results in a wavy appearance of the actin filaments in adult body wall muscles (PubMed:17684058).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi139E → K in lev-11-sy558; induces spicule protraction (Prc phenotype). Prc phenotype is suppressible by food deprivation. 1 Publication1
Mutagenesisi222E → K in lev-11-rg1; disrupts most steps of male mating behavior except spicule insertion. 1 Publication1
Mutagenesisi234E → K in lev-11-x12; confers levamisole resistance. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002056451 – 284Tropomyosin isoforms a/b/d/fAdd BLAST284

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22866

PeptideAtlas

More...
PeptideAtlasi
Q22866

PRoteomics IDEntifications database

More...
PRIDEi
Q22866

2D gel databases

The World-2DPAGE database

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World-2DPAGEi
0020:Q22866

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q22866

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform a and isoform d are expressed in body wall muscles, vulva, anus muscles and male tail muscles (PubMed:7666414). Located to the myofibrils of thin actin filaments (PubMed:11901171, PubMed:17684058).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002978 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q22866 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
38704, 28 interactors

Database of interacting proteins

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DIPi
DIP-27403N

Protein interaction database and analysis system

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IntActi
Q22866, 47 interactors

STRING: functional protein association networks

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STRINGi
6239.Y105E8B.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q22866

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 284Add BLAST284

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00950000182712

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231521

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q22866

KEGG Orthology (KO)

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KOi
K10373

Database of Orthologous Groups

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OrthoDBi
1576041at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q22866

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000533 Tropomyosin

Pfam protein domain database

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Pfami
View protein in Pfam
PF00261 Tropomyosin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00194 TROPOMYOSIN

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform a (identifier: Q22866-1) [UniParc]FASTAAdd to basket
Also known as: CeTM1, CeTMI

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAIKKKMQA MKIEKDNALD RADAAEEKVR QITEKLERVE EELRDTQKKM
60 70 80 90 100
TQTGDDLDKA QEDLSAATSK LEEKEKTVQE AEAEVASLNR RMTLLEEELE
110 120 130 140 150
RAEERLKIAT EKLEEATHNV DESERVRKVM ENRSLQDEER ANTVEAQLKE
160 170 180 190 200
AQLLAEEADR KYDEVARKLA MVEADLERAE ERAEAGENKI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKALQREDS YEEQIRTVSS RLKEAETRAE FAERSVQKLQ
260 270 280
KEVDRLEDEL VHEKERYKTI SEELDSTFQE LSGY
Length:284
Mass (Da):33,004
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02271C870E23D2AB
GO
Isoform b (identifier: Q22866-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.
     258-284: DELVHEKERYKTISEELDSTFQELSGY → ELRDAEVLKARQLQDELDHMVQELNSV

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):22,533
Checksum:iD1C80E8B905C439B
GO
Isoform d (identifier: Q22866-2) [UniParc]FASTAAdd to basket
Also known as: CeTM2, CeTMII

The sequence of this isoform differs from the canonical sequence as follows:
     258-284: DELVHEKERYKTISEELDSTFQELSGY → ELRDAEVLKARQLQDELDHMVQELNSV

Show »
Length:284
Mass (Da):32,937
Checksum:iD8D32CC6FB4E78F7
GO
Isoform f (identifier: Q22866-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-151: ERAEERLKIA...NTVEAQLKEA → NFSPRRLTAN...KRSCASLVIT
     152-284: Missing.

Note: No experimental confirmation available.
Show »
Length:151
Mass (Da):17,385
Checksum:i8C82011D1356E828
GO
Isoform e (identifier: Q27249-1) [UniParc]FASTAAdd to basket
Also known as: CeTM3, CeTMIII
The sequence of this isoform can be found in the external entry Q27249.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:256
Mass (Da):29,632
GO
Isoform c (identifier: Q27249-2) [UniParc]FASTAAdd to basket
Also known as: CeTM4, CeTMIV
The sequence of this isoform can be found in the external entry Q27249.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:256
Mass (Da):29,630
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q27249TPM3_CAEEL
Tropomyosin isoforms c/e
lev-11 tmy-1, Y105E8B.1
256Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ATS1A0A0K3ATS1_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K8FDX2K8FDX2_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AWP0A0A0K3AWP0_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARC0A0A0K3ARC0_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AQT4A0A0K3AQT4_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ATR6A0A0K3ATR6_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K8ERM4K8ERM4_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AQS9A0A0K3AQS9_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K8ESC3K8ESC3_CAEEL
Uncharacterized protein
lev-11 CELE_Y105E8B.1, Y105E8B.1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti277 – 279TFQ → NLP in BAA07540 (PubMed:7666414).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0206451 – 91Missing in isoform b. CuratedAdd BLAST91
Alternative sequenceiVSP_020646100 – 151ERAEE…QLKEA → NFSPRRLTANTTRSPVSSPW LKLILRELRSVPRPERTRSW SLKRSCASLVIT in isoform f. CuratedAdd BLAST52
Alternative sequenceiVSP_020647152 – 284Missing in isoform f. CuratedAdd BLAST133
Alternative sequenceiVSP_009425258 – 284DELVH…ELSGY → ELRDAEVLKARQLQDELDHM VQELNSV in isoform b and isoform d. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D38539 Genomic DNA Translation: BAA07540.1
D38539 Genomic DNA Translation: BAA07541.1
D38540 mRNA Translation: BAA07543.1
D38541 mRNA Translation: BAA07544.1
AL132877 Genomic DNA Translation: CAC70112.1
AL132877 Genomic DNA Translation: CAC70113.2
AL132877 Genomic DNA Translation: CAC70114.1
AL132877 Genomic DNA Translation: CAE54913.1

Protein sequence database of the Protein Information Resource

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PIRi
S58921
S58922

NCBI Reference Sequences

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RefSeqi
NP_001021695.1, NM_001026524.5 [Q22866-1]
NP_001021696.1, NM_001026525.5 [Q22866-3]
NP_001021698.1, NM_001026527.1 [Q22866-2]
NP_001021700.1, NM_001026529.4 [Q22866-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y105E8B.1a; Y105E8B.1a; WBGene00002978 [Q22866-1]
Y105E8B.1b.1; Y105E8B.1b.1; WBGene00002978 [Q22866-3]
Y105E8B.1b.2; Y105E8B.1b.2; WBGene00002978 [Q22866-3]
Y105E8B.1d; Y105E8B.1d; WBGene00002978 [Q22866-2]
Y105E8B.1f; Y105E8B.1f; WBGene00002978 [Q22866-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
173319

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_Y105E8B.1

UCSC genome browser

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UCSCi
Y105E8B.1e.2 c. elegans [Q22866-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38539 Genomic DNA Translation: BAA07540.1
D38539 Genomic DNA Translation: BAA07541.1
D38540 mRNA Translation: BAA07543.1
D38541 mRNA Translation: BAA07544.1
AL132877 Genomic DNA Translation: CAC70112.1
AL132877 Genomic DNA Translation: CAC70113.2
AL132877 Genomic DNA Translation: CAC70114.1
AL132877 Genomic DNA Translation: CAE54913.1
PIRiS58921
S58922
RefSeqiNP_001021695.1, NM_001026524.5 [Q22866-1]
NP_001021696.1, NM_001026525.5 [Q22866-3]
NP_001021698.1, NM_001026527.1 [Q22866-2]
NP_001021700.1, NM_001026529.4 [Q22866-4]

3D structure databases

SMRiQ22866
ModBaseiSearch...

Protein-protein interaction databases

BioGridi38704, 28 interactors
DIPiDIP-27403N
IntActiQ22866, 47 interactors
STRINGi6239.Y105E8B.1a

PTM databases

iPTMnetiQ22866

2D gel databases

World-2DPAGEi0020:Q22866

Proteomic databases

EPDiQ22866
PeptideAtlasiQ22866
PRIDEiQ22866

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY105E8B.1a; Y105E8B.1a; WBGene00002978 [Q22866-1]
Y105E8B.1b.1; Y105E8B.1b.1; WBGene00002978 [Q22866-3]
Y105E8B.1b.2; Y105E8B.1b.2; WBGene00002978 [Q22866-3]
Y105E8B.1d; Y105E8B.1d; WBGene00002978 [Q22866-2]
Y105E8B.1f; Y105E8B.1f; WBGene00002978 [Q22866-4]
GeneIDi173319
KEGGicel:CELE_Y105E8B.1
UCSCiY105E8B.1e.2 c. elegans [Q22866-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
173319
WormBaseiY105E8B.1a ; CE28782 ; WBGene00002978 ; lev-11
Y105E8B.1b ; CE36223 ; WBGene00002978 ; lev-11
Y105E8B.1d ; CE29060 ; WBGene00002978 ; lev-11
Y105E8B.1f ; CE36224 ; WBGene00002978 ; lev-11

Phylogenomic databases

GeneTreeiENSGT00950000182712
HOGENOMiHOG000231521
InParanoidiQ22866
KOiK10373
OrthoDBi1576041at2759
PhylomeDBiQ22866

Enzyme and pathway databases

ReactomeiR-CEL-445355 Smooth Muscle Contraction

Gene expression databases

BgeeiWBGene00002978 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiQ22866 baseline

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPM1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22866
Secondary accession number(s): Q22865
, Q27284, Q7K6W7, Q95Q31
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 1, 1996
Last modified: June 5, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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