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Entry version 117 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Uncharacterized protein T27F2.1

Gene

T27F2.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-CEL-72163, mRNA Splicing - Major Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q22836

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein T27F2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:T27F2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
T27F2.1 ; CE06519 ; WBGene00004806 ; skp-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000848291 – 535Uncharacterized protein T27F2.1Add BLAST535

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22836

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22836

PeptideAtlas

More...
PeptideAtlasi
Q22836

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q22836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004806, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
44623, 32 interactors

Database of interacting proteins

More...
DIPi
DIP-26404N

Protein interaction database and analysis system

More...
IntActi
Q22836, 6 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T27F2.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q22836

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni179 – 342SNWAdd BLAST164

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi133 – 136Poly-Asp4
Compositional biasi222 – 237Pro-richAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNW family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2441, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006601_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22836

Identification of Orthologs from Complete Genome Data

More...
OMAi
APPYGQR

Database of Orthologous Groups

More...
OrthoDBi
1455730at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22836

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017862, SKI-int_prot_SKIP
IPR004015, SKI-int_prot_SKIP_SNW-dom

The PANTHER Classification System

More...
PANTHERi
PTHR12096, PTHR12096, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02731, SKIP_SNW, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q22836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMKLRDILP APVAADEAAS QIRRDPWFGG RDNEPSAALV SKEPPPYGKR
60 70 80 90 100
TSFRPRGPED FGDGGAFPEI HVAQFPLGLG LGDMRGKPEN TLALQYGTDG
110 120 130 140 150
KLQHDAIARI GHVKDKVVYS KLNDMKAKTW NEDDDDIQKP DDDAVIDATE
160 170 180 190 200
KTRMALEKIV NSKVASALPV RHADKLAPAQ YIRYTPSQQN GAAGSQQRII
210 220 230 240 250
RMVEEQKDPM EPPKFKINQK IPRAPPSPPA PVMHSPPRKM TAKDQNDWKI
260 270 280 290 300
PPCISNWKNP KGFTVGLDKR LAADGRGLQQ THINENFAKL ADALYIADRK
310 320 330 340 350
AREEVETRAQ LERRVAQNKK SEQEAKMAEA AAKARQERSA MRRKDDEDDE
360 370 380 390 400
QVKVREEIRR DRLDDIRKER NIARSRPDKA DKLRKERERD ISEKIVLGLP
410 420 430 440 450
DTNQKRTGEP QFDQRLFDKT QGLDSGAMDD DTYNPYDAAW RGGDSVQQHV
460 470 480 490 500
YRPSKNLDND VYGGDLDKII EQKNRFVADK GFSGAEGSSR GSGPVQFEKD
510 520 530
QDVFGLSSLF EHTKEKKRGG DGGDSRGESK RSRRD
Length:535
Mass (Da):60,197
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DC7E46185A72716
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z74045 Genomic DNA Translation: CAA98552.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T25379

NCBI Reference Sequences

More...
RefSeqi
NP_505950.1, NM_073549.7

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T27F2.1.1; T27F2.1.1; WBGene00004806

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179598

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T27F2.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74045 Genomic DNA Translation: CAA98552.1
PIRiT25379
RefSeqiNP_505950.1, NM_073549.7

3D structure databases

SMRiQ22836
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi44623, 32 interactors
DIPiDIP-26404N
IntActiQ22836, 6 interactors
STRINGi6239.T27F2.1

PTM databases

iPTMnetiQ22836

Proteomic databases

EPDiQ22836
PaxDbiQ22836
PeptideAtlasiQ22836

Genome annotation databases

EnsemblMetazoaiT27F2.1.1; T27F2.1.1; WBGene00004806
GeneIDi179598
KEGGicel:CELE_T27F2.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179598
WormBaseiT27F2.1 ; CE06519 ; WBGene00004806 ; skp-1

Phylogenomic databases

eggNOGiKOG2441, Eukaryota
GeneTreeiENSGT00390000010423
HOGENOMiCLU_006601_2_0_1
InParanoidiQ22836
OMAiAPPYGQR
OrthoDBi1455730at2759
PhylomeDBiQ22836

Enzyme and pathway databases

ReactomeiR-CEL-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-CEL-72163, mRNA Splicing - Major Pathway
SignaLinkiQ22836

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q22836

Gene expression databases

BgeeiWBGene00004806, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR017862, SKI-int_prot_SKIP
IPR004015, SKI-int_prot_SKIP_SNW-dom
PANTHERiPTHR12096, PTHR12096, 1 hit
PfamiView protein in Pfam
PF02731, SKIP_SNW, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYGH1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22836
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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