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Entry version 148 (02 Jun 2021)
Sequence version 2 (02 Sep 2008)
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Protein

Myotubularin-related protein 3

Gene

mtm-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Preferentially dephosphorylates phosphatidylinositol 3-phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P) (PubMed:18393358, PubMed:25124690).

May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).

Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation (PubMed:25124690).

Thought to have a role in maintenance of muscle function (PubMed:18393358).

Involved in locomotion and lifespan determination (PubMed:18393358).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by sodium vanadate and peroxide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei463Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei509SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri818 – 883FYVE-typePROSITE-ProRule annotationAdd BLAST66

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase
Biological processLipid metabolism
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1632852, Macroautophagy
R-CEL-1660499, Synthesis of PIPs at the plasma membrane
R-CEL-1660516, Synthesis of PIPs at the early endosome membrane
R-CEL-1660517, Synthesis of PIPs at the late endosome membrane
R-CEL-2173788, Downregulation of TGF-beta receptor signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 3 (EC:3.1.3.48By similarity)
Short name:
ceMTM3
Alternative name(s):
Myotubularin homologous protein 1
Short name:
ceMTMH1
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.952 Publications)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.642 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mtm-3Imported
ORF Names:T24A11.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
T24A11.1a ; CE28087 ; WBGene00003476 ; mtm-3
T24A11.1b ; CE42568 ; WBGene00003476 ; mtm-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit a 2-fold increase in PI3P, sluggish body movement with progressive deterioration and defects in gestation.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67 – 1006Missing in tm4475; viable but display 36% embryonic lethality and 45% larval arrest. Reduces survival of L1 larvae in nutrient-deprived conditions. Defective autophagosome maturation and degradation of autophagic protein aggregates. 1 PublicationAdd BLAST940
Mutagenesisi463C → S: Abolished phosphatase activity towards phosphatidylinositol 3-phosphate (PI3P) phosphatidylinositol 3,5-bisphosphate (PI35P). 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000949471 – 1006Myotubularin-related protein 3Add BLAST1006

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22712

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22712

PeptideAtlas

More...
PeptideAtlasi
Q22712

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the body wall muscle and in eggs (PubMed:18393358). Expressed in head neurons (PubMed:12788949). Expressed in the intestine (PubMed:18393358, PubMed:25124690). Expressed in pharyngeal cells, vulval muscle cells and cells of the tail region (PubMed:25124690).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in most cells during embryogenesis (PubMed:25124690). Expressed most strongly in the egg with expression present in L1 but reducing through to L3 where it is very weak. No expression was found in L4. Strong expression is also seen in egg-laying adults and post-reproductive adults.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003476, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
40728, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T24A11.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q22712

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini224 – 630Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST407

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni377 – 380Substrate bindingBy similarity4
Regioni402 – 403Substrate bindingBy similarity2
Regioni463 – 469Substrate bindingBy similarity7
Regioni641 – 705DisorderedSequence analysisAdd BLAST65
Regioni886 – 1006DisorderedSequence analysisAdd BLAST121

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi651 – 705Polar residuesSequence analysisAdd BLAST55
Compositional biasi886 – 925Polar residuesSequence analysisAdd BLAST40
Compositional biasi930 – 953Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi954 – 970Polar residuesSequence analysisAdd BLAST17
Compositional biasi984 – 998Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Interacts with phosphatidylinositol 3-phosphate (PI3P) via the FYVE-type domain.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri818 – 883FYVE-typePROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1089, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000172447

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22712

Identification of Orthologs from Complete Genome Data

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OMAi
QSERENW

Database of Orthologous Groups

More...
OrthoDBi
824298at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22712

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR10807, PTHR10807, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363, FYVE, 1 hit
PF06602, Myotub-related, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064, FYVE, 1 hit
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q22712-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVTSSAAID IGGGGGGRRS DRLDSDRTSE DMSFIASPAN ESFQIGASFV
60 70 80 90 100
DVQNESSGSI DTATATLHEL NYTFGMPPVT EESENMPQNY ETVVELLPGE
110 120 130 140 150
ERAPINKLTE FPIEGGSLFV TNFRIVVILK DKEVEEALRF LVFPLQDIEQ
160 170 180 190 200
IDLAIPAFIH LSLKIGRMFT ICFKTAEDAA LVHKILYTAF QRLNRPISSI
210 220 230 240 250
YTSRPQDWTS KNTDNPMQSL NAFAWKFSEA VDELDRDGKL PSWLLRADSV
260 270 280 290 300
AQEITHIDFN RLGMSEHFQI SSVNENFEVC PTYPEKIIVP KGITDDDIRK
310 320 330 340 350
GAPYRSIGRF PAVIWRCRKT RAVLMRSSQP QVGILSWRNP TDEKIIEEAV
360 370 380 390 400
KASRIEGEEK KQFIIMDARG YTSAFANRAR SGGFENTEYY QQAKLEFLGL
410 420 430 440 450
PNIHAVRGSF NNVRTMLHNL GPNEQLLTSL QTTGWLLNLS NLLVNAANCA
460 470 480 490 500
DHLSKGHSVL VHCSDGWDRT TQVTTLAKIM LDEYYRTVKG FEELIRRDWI
510 520 530 540 550
AFGHKLYDRQ LVAFGNWGTS DERSPVFLQF LEAVRHLQRE QPTLFQFTHA
560 570 580 590 600
YLIKLAKHAY SGLFGSFLFN SHKERREAME KCKGTLVDIW RFIGPHNEEY
610 620 630 640 650
VNQSFDEHYT GAVKPVNVSV INLRVWHEVF ADEEEHYTQI FSPKEERPLS
660 670 680 690 700
GCTTPMNTST STNLVKSKSS ESINSLNVDG SAKESSQQHP TCSTTPSDNT
710 720 730 740 750
NSLPMSTSFI QQSLYQPKVR GVAAIDRDGV IRFEDDEQAM LRKKNKLRAE
760 770 780 790 800
EIRRKDEKIE ELRRRAVLDT NKVSPGQRQS YSESDVETTG TLERVMSDVS
810 820 830 840 850
MVDPVNELPH FKPNTTWEGE SGHCAYCKKE FNKLSVYVED RQHHCRNCGR
860 870 880 890 900
VVCEDCSKNR FSVIEEGKSV QKRACDSCYD SMHETDLKLS SSSTTTTSSS
910 920 930 940 950
TKIENDSNVP GLDNNSDNVS ENVSENAIPD IIVEEKEAED PIKEAESPSK
960 970 980 990 1000
ETKCPKTLRN FISFSPKSSM RKNKVHSRDP LKSIDEGSSS QQAESDDVLD

VNEQPL
Length:1,006
Mass (Da):113,614
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEFC03296E74DB1A
GO
Isoform bImported (identifier: Q22712-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-44: Missing.
     891-965: SSSTTTTSSS...KTLRNFISFS → RATSLSEMSS...RHSSTQAVKG
     966-1006: Missing.

Show »
Length:961
Mass (Da):108,189
Checksum:i7EAC08FCD831B9C9
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC78763 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03503541 – 44Missing in isoform b. 1 Publication4
Alternative sequenceiVSP_035036891 – 965SSSTT…FISFS → RATSLSEMSSFDSFGPSSPP ASSTSSSSLNMLASMSPTRP QPIPISCKSSSNSISSPRPS PGEFSRHSSTQAVKG in isoform b. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_035037966 – 1006Missing in isoform b. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF031519 mRNA Translation: AAC78763.1 Frameshift.
DQ988041 mRNA Translation: ABK59970.1
BX284603 Genomic DNA Translation: CAA88884.2
BX284603 Genomic DNA Translation: CAB61017.2

Protein sequence database of the Protein Information Resource

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PIRi
T25215

NCBI Reference Sequences

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RefSeqi
NP_001022794.2, NM_001027623.5 [Q22712-1]
NP_497766.3, NM_065365.6 [Q22712-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T24A11.1a.1; T24A11.1a.1; WBGene00003476 [Q22712-1]
T24A11.1b.1; T24A11.1b.1; WBGene00003476 [Q22712-2]
T24A11.1b.2; T24A11.1b.2; WBGene00003476 [Q22712-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
175490

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T24A11.1

UCSC genome browser

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UCSCi
T24A11.1b, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031519 mRNA Translation: AAC78763.1 Frameshift.
DQ988041 mRNA Translation: ABK59970.1
BX284603 Genomic DNA Translation: CAA88884.2
BX284603 Genomic DNA Translation: CAB61017.2
PIRiT25215
RefSeqiNP_001022794.2, NM_001027623.5 [Q22712-1]
NP_497766.3, NM_065365.6 [Q22712-2]

3D structure databases

SMRiQ22712
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi40728, 3 interactors
STRINGi6239.T24A11.1a

Proteomic databases

EPDiQ22712
PaxDbiQ22712
PeptideAtlasiQ22712

Genome annotation databases

EnsemblMetazoaiT24A11.1a.1; T24A11.1a.1; WBGene00003476 [Q22712-1]
T24A11.1b.1; T24A11.1b.1; WBGene00003476 [Q22712-2]
T24A11.1b.2; T24A11.1b.2; WBGene00003476 [Q22712-2]
GeneIDi175490
KEGGicel:CELE_T24A11.1
UCSCiT24A11.1b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
175490
WormBaseiT24A11.1a ; CE28087 ; WBGene00003476 ; mtm-3
T24A11.1b ; CE42568 ; WBGene00003476 ; mtm-3

Phylogenomic databases

eggNOGiKOG1089, Eukaryota
GeneTreeiENSGT00940000172447
InParanoidiQ22712
OMAiQSERENW
OrthoDBi824298at2759
PhylomeDBiQ22712

Enzyme and pathway databases

ReactomeiR-CEL-1632852, Macroautophagy
R-CEL-1660499, Synthesis of PIPs at the plasma membrane
R-CEL-1660516, Synthesis of PIPs at the early endosome membrane
R-CEL-1660517, Synthesis of PIPs at the late endosome membrane
R-CEL-2173788, Downregulation of TGF-beta receptor signaling

Miscellaneous databases

Protein Ontology

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PROi
PR:Q22712

Gene expression databases

BgeeiWBGene00003476, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR10807, PTHR10807, 2 hits
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
PF06602, Myotub-related, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50178, ZF_FYVE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMR3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22712
Secondary accession number(s): A8NBE6, Q9U360, Q9XTK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 2, 2008
Last modified: June 2, 2021
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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