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UniProtKB - Q22633 (HPPD_CAEEL)
Protein
4-hydroxyphenylpyruvate dioxygenase
Gene
hpd-1
Organism
Caenorhabditis elegans
Status
Functioni
Key enzyme in the degradation of tyrosine.
By similarity1 PublicationCatalytic activityi
- EC:1.13.11.27
Cofactori
Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
: L-phenylalanine degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine. This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 182 | IronBy similarity | 1 | |
Metal bindingi | 267 | IronBy similarity | 1 | |
Metal bindingi | 350 | IronBy similarity | 1 |
GO - Molecular functioni
- 4-hydroxyphenylpyruvate dioxygenase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- L-phenylalanine catabolic process Source: UniProtKB-UniPathway
- tyrosine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Phenylalanine catabolism, Tyrosine catabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-CEL-8963684, Tyrosine catabolism |
UniPathwayi | UPA00139;UER00362 |
Names & Taxonomyi
Protein namesi | Recommended name: 4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)Alternative name(s): 4-hydroxyphenylpyruvic acid oxidase Short name: 4HPPD Short name: HPD Short name: HPPDase |
Gene namesi | Name:hpd-1Imported ORF Names:T21C12.2Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | T21C12.2 ; CE02347 ; WBGene00001993 ; hpd-1 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- Golgi membrane Source: GO_Central
Pathology & Biotechi
Disruption phenotypei
RNAi-mediated knockdown together with fah-1 RNAi rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088395 | 1 – 393 | 4-hydroxyphenylpyruvate dioxygenaseAdd BLAST | 393 |
Proteomic databases
EPDi | Q22633 |
PaxDbi | Q22633 |
PeptideAtlasi | Q22633 |
2D gel databases
World-2DPAGEi | 0020:Q22633 |
Expressioni
Tissue specificityi
Expressed in the hypodermis and intestine.1 Publication
Gene expression databases
Bgeei | WBGene00001993, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 41664, 11 interactors |
STRINGi | 6239.T21C12.2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 148 | VOC 1PROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 179 – 339 | VOC 2PROSITE-ProRule annotationAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the 4HPPD family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0638, Eukaryota |
GeneTreei | ENSGT00530000063474 |
HOGENOMi | CLU_034004_3_1_1 |
InParanoidi | Q22633 |
OMAi | DPFPVKG |
OrthoDBi | 1087836at2759 |
PhylomeDBi | Q22633 |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 1 hit |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
i Sequence
Sequence statusi: Complete.
Q22633-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTFDKGAKP DIGTFVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE
60 70 80 90 100
TGSRITAQHA IRQDKIVFIF ESALLPDNSE LGNHLVQHGD GVKDVCFEVE
110 120 130 140 150
DLDSIIAHAK AAGATIVHDI TEESDADGSI RYATLRTYGE TDHTLLERKN
160 170 180 190 200
YRGAFLPGFK AHPMPATFFK TLPRVGLNFL DHCVGNQPDL QMDSAVQWYE
210 220 230 240 250
KVLKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN EPATSDKKAI
260 270 280 290 300
SQIQEYVDYY GGSGVQHIAL NTSDIITAIE ALRARGCEFL SIPSSYYDNL
310 320 330 340 350
KERLAASSMV VKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE
360 370 380 390
IIQRQNHEGF GAGNFKALFE SIELEQTKRG NLFYDNVKDG NTK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284603 Genomic DNA Translation: CAA90315.1 |
PIRi | T25063 |
RefSeqi | NP_499324.1, NM_066923.6 |
Genome annotation databases
EnsemblMetazoai | T21C12.2.1; T21C12.2.1; WBGene00001993 |
GeneIDi | 176473 |
UCSCi | T21C12.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284603 Genomic DNA Translation: CAA90315.1 |
PIRi | T25063 |
RefSeqi | NP_499324.1, NM_066923.6 |
3D structure databases
SMRi | Q22633 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 41664, 11 interactors |
STRINGi | 6239.T21C12.2 |
2D gel databases
World-2DPAGEi | 0020:Q22633 |
Proteomic databases
EPDi | Q22633 |
PaxDbi | Q22633 |
PeptideAtlasi | Q22633 |
Genome annotation databases
EnsemblMetazoai | T21C12.2.1; T21C12.2.1; WBGene00001993 |
GeneIDi | 176473 |
UCSCi | T21C12.2, c. elegans |
Organism-specific databases
CTDi | 176473 |
WormBasei | T21C12.2 ; CE02347 ; WBGene00001993 ; hpd-1 |
Phylogenomic databases
eggNOGi | KOG0638, Eukaryota |
GeneTreei | ENSGT00530000063474 |
HOGENOMi | CLU_034004_3_1_1 |
InParanoidi | Q22633 |
OMAi | DPFPVKG |
OrthoDBi | 1087836at2759 |
PhylomeDBi | Q22633 |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00362 |
Reactomei | R-CEL-8963684, Tyrosine catabolism |
Miscellaneous databases
PROi | PR:Q22633 |
Gene expression databases
Bgeei | WBGene00001993, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 1 hit |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | HPPD_CAEEL | |
Accessioni | Q22633Primary (citable) accession number: Q22633 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families