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Entry version 146 (18 Sep 2019)
Sequence version 2 (01 Oct 2002)
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Protein

Apple domain-containing protein

Gene

CELE_T21B6.3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apple domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CELE_T21B6.3Imported, T21B6.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T21B6.3 ; CE31621 ; WBGene00011880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500420113220 – 821Apple domain-containing proteinSequence analysisAdd BLAST802

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22631

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22631

PeptideAtlas

More...
PeptideAtlasi
Q22631

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011880 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-24494N

Protein interaction database and analysis system

More...
IntActi
Q22631, 15 interactors

Molecular INTeraction database

More...
MINTi
Q22631

STRING: functional protein association networks

More...
STRINGi
6239.T21B6.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q22631

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 115AppleInterPro annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 172DisorderedSequence analysisAdd BLAST40
Regioni192 – 356DisorderedSequence analysisAdd BLAST165
Regioni378 – 409DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi133 – 157PolyampholyteSequence analysisAdd BLAST25
Compositional biasi215 – 229PolarSequence analysisAdd BLAST15
Compositional biasi244 – 260PolarSequence analysisAdd BLAST17
Compositional biasi261 – 279Pro-richSequence analysisAdd BLAST19
Compositional biasi295 – 356PolarSequence analysisAdd BLAST62

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1PA Eukaryota
ENOG410YJXG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000038972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021130

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22631

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEWCEWS

Database of Orthologous Groups

More...
OrthoDBi
317765at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003609 Pan_app
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00090 TSP_1, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00473 PAN_AP, 1 hit
SM00209 TSP1, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895 SSF82895, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50092 TSP1, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q22631-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQATVGLFAL AVLFCLADAG RISVSRGKNV TKIDDLCARM HNNTALEGSS
60 70 80 90 100
PLLMMQATAY ECQKKCVDIF PECSAVVYYY LHNETKKHFC YLFSDNSVQD
110 120 130 140 150
KIDLVEQKPE NKKDIVRMLE LVVDCHQFDA HPPLEEDGLA SSTDKVDRKK
160 170 180 190 200
RQQGDEAVEG VGDWTDWSHC SSNGHEVRSQ ACEYGRKIQR RGCPARSAPQ
210 220 230 240 250
RVPAPPAQQY APRAPEYPSA QQQQQQREQQ QREQQHREHQ ARLQQHQQQQ
260 270 280 290 300
QQQQQQQQQR PPQPQPQPQP QPPQRPPQQP QSFSGTHELH LQRQREQQQQ
310 320 330 340 350
QQQQQQQQQQ RQQNPQQQPQ QTTQFGQSQI QLQSGPVPPQ QHPQQQQPQQ
360 370 380 390 400
QPELERSPLD QHAQLYQQRM SQYRENFNQR HPARPKADPC PGGFCAPVPQ
410 420 430 440 450
APQQERPTPP PVLAPVINTA TQPPLPQPYP TRYRPAPPPP PACDGQGCVN
460 470 480 490 500
PPVVSGVWHD WSDWSTCSCT CGDGAKSRRR ECSTNNCQGA DYETEPCNLG
510 520 530 540 550
PCQTWSEWCE WSTCSASCGS GQRERTRFCH LGTNRCEGKD YESEQCSAGP
560 570 580 590 600
CPEWSQWEDW GQCSVTCGQG VAVRQRTCLG GVFGDHLCQG PKTEQRACDG
610 620 630 640 650
GPCSLWSPWQ EWSTCSASCG SGMKRRQRVC QFGTDCQGPN EESQFCYGPP
660 670 680 690 700
CAEWTEWCEW SGCSSKCGPG QRTRTRGCLG PNGQEATTCQ GPSIETTLCE
710 720 730 740 750
GQSCCNWSEW CHWSMCDKEC GGGQSIRTRT CLNSAGSPDS SCHCDGPDRE
760 770 780 790 800
EKECNSQSCA PQCAWNTWCE WSPCSTQLAC EVGVQSRSRQ CVGESGCHCI
810 820
GLAEESQQCR GLTQCPPKPP C
Length:821
Mass (Da):92,125
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61B82584DC50D2A9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA92014.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T25061

NCBI Reference Sequences

More...
RefSeqi
NP_509829.2, NM_077428.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T21B6.3.1; T21B6.3.1; WBGene00011880

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181284

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T21B6.3

UCSC genome browser

More...
UCSCi
T21B6.3 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA92014.2
PIRiT25061
RefSeqiNP_509829.2, NM_077428.4

3D structure databases

SMRiQ22631
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-24494N
IntActiQ22631, 15 interactors
MINTiQ22631
STRINGi6239.T21B6.3

Proteomic databases

EPDiQ22631
PaxDbiQ22631
PeptideAtlasiQ22631

Genome annotation databases

EnsemblMetazoaiT21B6.3.1; T21B6.3.1; WBGene00011880
GeneIDi181284
KEGGicel:CELE_T21B6.3
UCSCiT21B6.3 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181284
WormBaseiT21B6.3 ; CE31621 ; WBGene00011880

Phylogenomic databases

eggNOGiENOG410J1PA Eukaryota
ENOG410YJXG LUCA
GeneTreeiENSGT00440000038972
HOGENOMiHOG000021130
InParanoidiQ22631
OMAiSEWCEWS
OrthoDBi317765at2759

Gene expression databases

BgeeiWBGene00011880 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR003609 Pan_app
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00090 TSP_1, 7 hits
SMARTiView protein in SMART
SM00473 PAN_AP, 1 hit
SM00209 TSP1, 8 hits
SUPFAMiSSF82895 SSF82895, 7 hits
PROSITEiView protein in PROSITE
PS50092 TSP1, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ22631_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22631
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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