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Entry version 147 (29 Sep 2021)
Sequence version 2 (01 Nov 2002)
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Protein

Double-stranded RNA-specific adenosine deaminase adr-2

Gene

adr-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375).

Acts primarily on non-coding regions of protein-coding genes including introns and untranslated regions (UTR) (PubMed:28925356, PubMed:25373143).

Required for normal chemotaxis (PubMed:12426375, PubMed:14657490).

Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis (PubMed:28925356).

Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143).

Not required for RNA interference (PubMed:12419225).

Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).

6 Publications

Miscellaneous

Can prevent somatic transgenes from inducing gene silencing via the RNA interference (RNAi) pathway. This may occur due to A-to-I editing of transgene-derived dsRNA, preventing transgene RNAi.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi191ZincPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei193Proton donorPROSITE-ProRule annotation1
Metal bindingi244ZincPROSITE-ProRule annotation1
Metal bindingi305ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processChemotaxis, mRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-75102, C6 deamination of adenosine
R-CEL-77042, Formation of editosomes by ADAR proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Double-stranded RNA-specific adenosine deaminase adr-2Curated (EC:3.5.4.371 Publication)
Short name:
DRADA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:adr-2
ORF Names:T20H4.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
T20H4.4 ; CE25120 ; WBGene00000080 ; adr-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi184G → R: Abolishes editing of clec-41 RNA, leads to a threefold reduction in expression of clec-41 mRNA in neural cells and impairs chemotaxis. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001717781 – 495Double-stranded RNA-specific adenosine deaminase adr-2Add BLAST495

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22618

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22618

PeptideAtlas

More...
PeptideAtlasi
Q22618

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q22618

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highest expression observed in the embryo. Levels decrease dramatically after embryogenesis, remain relatively constant during larval stages and increase again at the onset of adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000080, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with A-to-I RNA editing regulator adr-1 (PubMed:24508457).

Interacts with adbp-1; the interaction facilitates adr-2 nuclear localization (PubMed:18780728).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
41234, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-26710N

Protein interaction database and analysis system

More...
IntActi
Q22618, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.T20H4.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 105DRBMPROSITE-ProRule annotationAdd BLAST70
Domaini167 – 492A to I editasePROSITE-ProRule annotationAdd BLAST326

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2777, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157243

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005382_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22618

Identification of Orthologs from Complete Genome Data

More...
OMAi
HAFSARW

Database of Orthologous Groups

More...
OrthoDBi
947117at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22618

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002466, A_deamin
IPR014720, dsRBD_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02137, A_deamin, 1 hit
PF00035, dsrm, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00552, ADEAMc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50141, A_DEAMIN_EDITASE, 1 hit
PS50137, DS_RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q22618-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVEEGMEVE LKSEKMDLDD NIPDFVKETV ERSGKNPMSL FSELYVHMTG
60 70 80 90 100
NTPVFDFYNR NQPNGSMKFI CVVILNGERI EGNVKSKKKE AKVSCSLKGL
110 120 130 140 150
EVVLKHVSEY VVPAVKFEEK TTFFEMLREH TYAKFYELCK NNALIYGFEK
160 170 180 190 200
VIASVFLKIN GNLQIIALST GNKGLRGDKI VNDGTALIDC HAEILARRGL
210 220 230 240 250
LRFLYSEVLK FSTEPPNSIF TKGKNALVLK PGISFHLFIN TAPCGVARID
260 270 280 290 300
KKLKPGTSDD LQNSSRLRFK IDKGMGTVLG GASEFEAPQT FDGIMMGERM
310 320 330 340 350
RTMSCSDKLL RANVLGVQGA ILSHFIDPIY YSSIAVAELN NADRLRKAVY
360 370 380 390 400
SRAATFKPPA PFHVQDVEIG ECQVEDTEQS TSAAARSTIS SMNWNLADGN
410 420 430 440 450
TEVVRTSDGM VHDKDMSGAD ITTPSRLCKK NMAELMITIC TLTKTSVDYP
460 470 480 490
ISYEELKAGS QEYAAAKKSF ITWLRQKDLG IWQRKPREFQ MFTIN
Length:495
Mass (Da):55,320
Last modified:November 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDE9D9E06A5A8A89
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF051275 mRNA Translation: AAC25097.1
FO081693 Genomic DNA Translation: CCD73351.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16913
T42758

NCBI Reference Sequences

More...
RefSeqi
NP_498594.1, NM_066193.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T20H4.4.1; T20H4.4.1; WBGene00000080
T20H4.4.2; T20H4.4.2; WBGene00000080

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T20H4.4

UCSC genome browser

More...
UCSCi
T20H4.4.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051275 mRNA Translation: AAC25097.1
FO081693 Genomic DNA Translation: CCD73351.1
PIRiT16913
T42758
RefSeqiNP_498594.1, NM_066193.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi41234, 8 interactors
DIPiDIP-26710N
IntActiQ22618, 1 interactor
STRINGi6239.T20H4.4

PTM databases

iPTMnetiQ22618

Proteomic databases

EPDiQ22618
PaxDbiQ22618
PeptideAtlasiQ22618

Genome annotation databases

EnsemblMetazoaiT20H4.4.1; T20H4.4.1; WBGene00000080
T20H4.4.2; T20H4.4.2; WBGene00000080
GeneIDi176022
KEGGicel:CELE_T20H4.4
UCSCiT20H4.4.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176022
WormBaseiT20H4.4 ; CE25120 ; WBGene00000080 ; adr-2

Phylogenomic databases

eggNOGiKOG2777, Eukaryota
GeneTreeiENSGT00940000157243
HOGENOMiCLU_005382_3_1_1
InParanoidiQ22618
OMAiHAFSARW
OrthoDBi947117at2759
PhylomeDBiQ22618

Enzyme and pathway databases

ReactomeiR-CEL-75102, C6 deamination of adenosine
R-CEL-77042, Formation of editosomes by ADAR proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q22618

Gene expression databases

BgeeiWBGene00000080, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002466, A_deamin
IPR014720, dsRBD_dom
PfamiView protein in Pfam
PF02137, A_deamin, 1 hit
PF00035, dsrm, 1 hit
SMARTiView protein in SMART
SM00552, ADEAMc, 1 hit
PROSITEiView protein in PROSITE
PS50141, A_DEAMIN_EDITASE, 1 hit
PS50137, DS_RBD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSRAD_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22618
Secondary accession number(s): O76295
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 2002
Last modified: September 29, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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