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Entry version 153 (12 Aug 2020)
Sequence version 2 (01 Jun 2002)
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Protein

Rab-3-interacting molecule unc-10

Gene

unc-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structural organization of synapses. May play a role in regulating entry into the dauer state (PubMed:30460068).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri66 – 121FYVE-typePROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-181429, Serotonin Neurotransmitter Release Cycle
R-CEL-181430, Norepinephrine Neurotransmitter Release Cycle
R-CEL-210500, Glutamate Neurotransmitter Release Cycle
R-CEL-212676, Dopamine Neurotransmitter Release Cycle
R-CEL-264642, Acetylcholine Neurotransmitter Release Cycle
R-CEL-888590, GABA synthesis, release, reuptake and degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab-3-interacting molecule unc-10
Short name:
Rim
Alternative name(s):
Uncoordinated protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-10Imported
ORF Names:T10A3.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T10A3.1a ; CE30169 ; WBGene00006750 ; unc-10
T10A3.1b ; CE31234 ; WBGene00006750 ; unc-10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902101 – 1563Rab-3-interacting molecule unc-10Add BLAST1563

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22366

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22366

PeptideAtlas

More...
PeptideAtlasi
Q22366

PRoteomics IDEntifications database

More...
PRIDEi
Q22366

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q22366

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to discrete puncta in synapse-rich regions of the nervous system including the nerve ring, the ventral nerve cord and the dorsal nerve cord. Localized expression was found in the head.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Observed in all larval stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006750, Expressed in material anatomical entity and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q22366, 7 interactors

Molecular INTeraction database

More...
MINTi
Q22366

STRING: functional protein association networks

More...
STRINGi
6239.T10A3.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q22366

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 133RabBDPROSITE-ProRule annotationAdd BLAST127
Domaini643 – 733PDZPROSITE-ProRule annotationAdd BLAST91
Domaini840 – 962C2 1PROSITE-ProRule annotationAdd BLAST123
Domaini1417 – 1536C2 2PROSITE-ProRule annotationAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi117 – 420Asn/Gln-richAdd BLAST304
Compositional biasi1176 – 1236Gln-richAdd BLAST61

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 121FYVE-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060, Eukaryota
KOG3528, Eukaryota
KOG3799, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168297

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001061_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22366

KEGG Orthology (KO)

More...
KOi
K15297

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEDGRYK

Database of Orthologous Groups

More...
OrthoDBi
109268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22366

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12157, PTHR12157, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF17820, PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform aImported (identifier: Q22366-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDPSMMPDL SHLSAEEREI IENVFKRQKD EEAKETQISQ KASEELSELD
60 70 80 90 100
KQITERKETS KKLVGTQDDA ICQICQKTKF ADGIGHKCFY CQLRSCARCG
110 120 130 140 150
GRAQSKNKAI WACSLCQKRQ QILAKTGKWF QPEEQPQPKI SGSEPSPSPQ
160 170 180 190 200
PLTDDNVPEP QQRRAEPPDK MNTPNYQNNQ QPRGMGMQPN HNQTQQNFMN
210 220 230 240 250
QNQNSNQHPN QNHNQNQMQN PHQNQNHVQN NHQGANNHQQ NNRRAMQQQP
260 270 280 290 300
MSQNQANQIN QMNQNQNQQQ SHNQNMTQNQ RNQTGPQNQQ RTNDSRTMKQ
310 320 330 340 350
TPQQQPSQYQ NNVGAAHQHH NQHGQQEQHH QQMNEQRTDN NRMRENTNGQ
360 370 380 390 400
GGMFNRQPSL EQTTPMNKYN HVEDDGMNQR PTFYTGNSEN DQRQFDGQMQ
410 420 430 440 450
QGSQQNNQNQ NQNNRNLRKN TVSRVTEEDY ASSSNFESKK QRNNSSQSQS
460 470 480 490 500
NTQGVRACPS TDDHLNRVKN RLHRQLRSMS SSEEDIIAGG GGNTLKMSTS
510 520 530 540 550
AVVASGGKTA FHDDMGASNV QRLSEECNSE KDLLRYIYGD HKNSDSSSLG
560 570 580 590 600
AGVGGSGGGG VLSGNSVLKS KSHALLKGSY QGGLDMQANR RRDKSLSLSP
610 620 630 640 650
SRNDHFGTGS ISGGDLLASR IRTFLSHPVT WQPSADQKKL IGHMILHRTE
660 670 680 690 700
NSAANGDLGL KIVGGRRTDT GKLGAFITQV KPGSVADTIG RLRPGDEVVE
710 720 730 740 750
WNGQSLQNAT YEQVYDSIAA SRYDTSVELI VSRSAIIPGG DDFLNLTPSQ
760 770 780 790 800
MSSSAYSRVP SAYPSQFQRQ LPNPDLFLDI HPALQQLSLP HSQSAVFPHN
810 820 830 840 850
NTLTSRNRST SSYYYSDVPD LGVPSNREMQ ESQAFGTGHI FGRIEVSFVY
860 870 880 890 900
SHHDRQLSVA LVRGFDLPPR SDGTPRNPYV KIFLLPDRSE KSRRQSAVIA
910 920 930 940 950
ETLMPVWDEV FYYNGLTEPM LLQRVLELTV WDYDKFGTNS FLGETLIDLA
960 970 980 990 1000
SVPLDGEHSL MCILVDMDDD NPLRTVISIF KFHVIILTFL QRLKLRKASY
1010 1020 1030 1040 1050
NAPTRRPQSE LNYYDHSSNY YDHISQNIDK QPHHHHLAPN DEENDEYIDD
1060 1070 1080 1090 1100
DELENDIDLA TGGGARKSRT YRREKGMHGG HGYADWTQNH QRQSGYTSDH
1110 1120 1130 1140 1150
GYGRQNMIGR AYNRRQQRRP RSATALSQME REDMYDPTRK HRDDNEYSMR
1160 1170 1180 1190 1200
ESVRHGSQYY LGDQPLYEDG RYKISQGQMT PKQHNQQHQP HPLSQAHQQQ
1210 1220 1230 1240 1250
QTAGVQPQHH QGFQQQQHPQ QPNQQMQQMQ PPMPNQGYYS DGSETLSVHS
1260 1270 1280 1290 1300
TNSMPTTMTT VNRRNMNANN TSNDNTSFAE TPTANTNRVP IKETKQNSLA
1310 1320 1330 1340 1350
SSSSVAGGGS AANNVMKERK KSLMTRFIPG RGAEGKRTGF ARSEEVGIPG
1360 1370 1380 1390 1400
NLSSDRLTEP TPPFLKQASK ESTDSAHSDK FARQCWLPVL ADGPLGTFVD
1410 1420 1430 1440 1450
NLGPGQVVGR QVLASPVLGE IQIALMAGRS GIDVEIIKAK NLVVKPGVKV
1460 1470 1480 1490 1500
CPAPYVKVYL MEGKQCIAKA KTNAATKTTS PLFQQHLIFN DSPKKKTLQV
1510 1520 1530 1540 1550
TVLGDYGRME RKVFMGISQI RLEDLELGSQ PLIGWYKLFH SSSLAGTGPV
1560
RKDSDVSVGG AQQ
Length:1,563
Mass (Da):175,479
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77EE93619C24E899
GO
Isoform bImported (identifier: Q22366-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     976-991: Missing.
     1386-1387: WL → AR
     1388-1563: Missing.

Show »
Length:1,371
Mass (Da):154,681
Checksum:iB6D7D918E58EFB71
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5E4LWH4A0A5E4LWH4_CAEEL
Rab-3-interacting molecule unc-10
unc-10 CELE_T10A3.1, T10A3.1
1,527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5E4LXW2A0A5E4LXW2_CAEEL
Rab-3-interacting molecule unc-10
unc-10 CELE_T10A3.1, T10A3.1
1,424Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5E4LYK9A0A5E4LYK9_CAEEL
Rab-3-interacting molecule unc-10
unc-10 CELE_T10A3.1, T10A3.1
1,529Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5E4M2M0A0A5E4M2M0_CAEEL
Rab-3-interacting molecule unc-10
unc-10 CELE_T10A3.1, T10A3.1
1,422Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009139976 – 991Missing in isoform b. CuratedAdd BLAST16
Alternative sequenceiVSP_0091401386 – 1387WL → AR in isoform b. Curated2
Alternative sequenceiVSP_0091411388 – 1563Missing in isoform b. CuratedAdd BLAST176

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF257062 mRNA Translation: AAK49331.1
BX284606 Genomic DNA Translation: CCD71364.1
BX284606 Genomic DNA Translation: CCD71365.1

Protein sequence database of the Protein Information Resource

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PIRi
T29736

NCBI Reference Sequences

More...
RefSeqi
NP_001024901.1, NM_001029730.3 [Q22366-2]
NP_741831.1, NM_171720.3 [Q22366-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T10A3.1a.1; T10A3.1a.1; WBGene00006750 [Q22366-1]
T10A3.1b.1; T10A3.1b.1; WBGene00006750 [Q22366-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
180990

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T10A3.1

UCSC genome browser

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UCSCi
T10A3.1b, c. elegans [Q22366-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257062 mRNA Translation: AAK49331.1
BX284606 Genomic DNA Translation: CCD71364.1
BX284606 Genomic DNA Translation: CCD71365.1
PIRiT29736
RefSeqiNP_001024901.1, NM_001029730.3 [Q22366-2]
NP_741831.1, NM_171720.3 [Q22366-1]

3D structure databases

SMRiQ22366
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ22366, 7 interactors
MINTiQ22366
STRINGi6239.T10A3.1a

PTM databases

iPTMnetiQ22366

Proteomic databases

EPDiQ22366
PaxDbiQ22366
PeptideAtlasiQ22366
PRIDEiQ22366

Genome annotation databases

EnsemblMetazoaiT10A3.1a.1; T10A3.1a.1; WBGene00006750 [Q22366-1]
T10A3.1b.1; T10A3.1b.1; WBGene00006750 [Q22366-2]
GeneIDi180990
KEGGicel:CELE_T10A3.1
UCSCiT10A3.1b, c. elegans [Q22366-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
180990
WormBaseiT10A3.1a ; CE30169 ; WBGene00006750 ; unc-10
T10A3.1b ; CE31234 ; WBGene00006750 ; unc-10

Phylogenomic databases

eggNOGiKOG2060, Eukaryota
KOG3528, Eukaryota
KOG3799, Eukaryota
GeneTreeiENSGT00940000168297
HOGENOMiCLU_001061_3_1_1
InParanoidiQ22366
KOiK15297
OMAiYEDGRYK
OrthoDBi109268at2759
PhylomeDBiQ22366

Enzyme and pathway databases

ReactomeiR-CEL-181429, Serotonin Neurotransmitter Release Cycle
R-CEL-181430, Norepinephrine Neurotransmitter Release Cycle
R-CEL-210500, Glutamate Neurotransmitter Release Cycle
R-CEL-212676, Dopamine Neurotransmitter Release Cycle
R-CEL-264642, Acetylcholine Neurotransmitter Release Cycle
R-CEL-888590, GABA synthesis, release, reuptake and degradation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q22366

Gene expression databases

BgeeiWBGene00006750, Expressed in material anatomical entity and 4 other tissues

Family and domain databases

Gene3Di2.30.42.10, 1 hit
2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR12157, PTHR12157, 2 hits
PfamiView protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF17820, PDZ_6, 1 hit
SMARTiView protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIM_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22366
Secondary accession number(s): Q22367, Q8MPX5, Q95WX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2002
Last modified: August 12, 2020
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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