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Entry version 126 (11 Dec 2019)
Sequence version 2 (06 Jul 2016)
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Protein
Submitted name:

ATG11 domain-containing protein

Gene

epg-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • molecular adaptor activity Source: WormBase
  • protein kinase binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1632852 Macroautophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATG11 domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:epg-7Imported
Synonyms:atg-11Imported
ORF Names:CELE_T08A9.1Imported, T08A9.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T08A9.1 ; CE51575 ; WBGene00020334 ; epg-7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22342

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22342

PeptideAtlas

More...
PeptideAtlasi
Q22342

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00020334 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T08A9.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q22342

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1233 – 1322ATG11InterPro annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni609 – 669DisorderedSequence analysisAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili767 – 804Sequence analysisAdd BLAST38
Coiled coili836 – 870Sequence analysisAdd BLAST35
Coiled coili923 – 953Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi622 – 663PolarSequence analysisAdd BLAST42

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4572 Eukaryota
ENOG410XSY4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019311

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22342

KEGG Orthology (KO)

More...
KOi
K17589

Database of Orthologous Groups

More...
OrthoDBi
91906at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040040 ATG11
IPR019460 Atg11_C

The PANTHER Classification System

More...
PANTHERi
PTHR13222 PTHR13222, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10377 ATG11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q22342-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMYHIFYMD RGQAMVFDLN AETTTFNVLQ DMVSKEVGHR ISDLTFLDES
60 70 80 90 100
GTTPDGNKSL AEISTLGTET SPVYFFLKSG NERENHNGSD VTYIFQMIDD
110 120 130 140 150
AVDQAQYVLK NQDPLKIYME LPERAKNCRK VCAETLQMCA RLVQQHRFLH
160 170 180 190 200
KGWLALINNL DISVSKMDKR GKKFKLVHSK SEELIEKSDT LLLNYSDVVE
210 220 230 240 250
QLRRIEVPSE IFVKPASLMT STSTPINPDE KCTLFDFIAM ADPEASLDGL
260 270 280 290 300
PDLVNEKIRQ LKEQNAISVY TRLQSVHETS KNQEYRDFKG INKRFSQLEF
310 320 330 340 350
SLKSCEERKN LVHKLVAQIL ETPKINDQNK LPPIIEEHRQ CMLTIFENFS
360 370 380 390 400
EFRNMVRVFD QSKQEILKNL RTRMSGFVVQ NYDRLRVVLN DIVQYEYKSN
410 420 430 440 450
AVRIHMDLIG QIRDAPILYS QSVSEIVRRR LLKTELEEWH TDHSTKCAQF
460 470 480 490 500
STDEEKSREQ LGRKLKKHFL HALFPGLFDN LPEFYVKAPL EKYDTDLPNI
510 520 530 540 550
AKEYIKDLRD ALPELEPFLK VTLPNVASKL ATKGSKQHPS FGQTRVESFL
560 570 580 590 600
TDEPMRMARS HFNYSPAAWL SEDGGDSSPV PQPLMCRSPE NALRESQCRS
610 620 630 640 650
IPYVPSLQQL EGLDGPAPGS SAPISIPNST SSRINFKQSG RQQSSQDLHH
660 670 680 690 700
VGSAVSSDTS LLGHETPVKM EDTVLMTENK SELNLESNMN DSNDSIDSLL
710 720 730 740 750
DVYEHIDYSA EDILLGLSDH TVQLEDAVKR LSKMQNIVAN MTPRNEKLFK
760 770 780 790 800
YLHQTAPRDF EIIIHDGDKL KNRVKELGES VESLETELEN KKSTESNLEA
810 820 830 840 850
KLAEMTVSHK KEIENTQAEC IKRMSVEFEL MTDSMSRQSK EQIESKDREI
860 870 880 890 900
EELKAKLEKQ NIAHEKALRN DPYSEEYKRT LTAEIRAELE KEFKQRIEVI
910 920 930 940 950
TKAVECKKDE AFARQEKTLE IENRVLSSEN ESKSKKLEAM NREKEQLESL
960 970 980 990 1000
IRQMPEGEVI LDEFNALKES QPSAQIKDRF AAIRSRMERS TDGKCLDTNK
1010 1020 1030 1040 1050
VLLIDNILKV HKLQQLVNER EQYRDVIKSQ PGGDQVLQFL ENSTPTVPVD
1060 1070 1080 1090 1100
MEAYFNELTN FSGSFDEAGR KIAKIHEIAM ETIWLQALVR ANLGGPSLRD
1110 1120 1130 1140 1150
ISADIHKESY QKDVETVTSI AMMDIFIDHD RDEIKKLTRT LQIWLNTNVS
1160 1170 1180 1190 1200
SLRSGGTYAI EDSPKIRECA SKYKSMALKV STYQGMEESF YQPMAASTIQ
1210 1220 1230 1240 1250
VATSPSELEV ERSSQNTICT QTRLCLPAMN LLVSVQDIKI GCAVIVIWHQ
1260 1270 1280 1290 1300
AHNAYVIFCS SPNRYFVKES SIRRLGINTQ NAATRRNWII ARVVRSDSCS
1310 1320 1330
IKKPVNRYNL PIGTIVRRVE VEAVNMDFEG DFNHISIA
Length:1,338
Mass (Da):153,127
Last modified:July 6, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i264586CD7AAE508C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD63514.2

Protein sequence database of the Protein Information Resource

More...
PIRi
H89567

NCBI Reference Sequences

More...
RefSeqi
NP_509241.2, NM_076840.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T08A9.1.1; T08A9.1.1; WBGene00020334

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180996

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T08A9.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD63514.2
PIRiH89567
RefSeqiNP_509241.2, NM_076840.6

3D structure databases

SMRiQ22342
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.T08A9.1

Proteomic databases

EPDiQ22342
PaxDbiQ22342
PeptideAtlasiQ22342

Genome annotation databases

EnsemblMetazoaiT08A9.1.1; T08A9.1.1; WBGene00020334
GeneIDi180996
KEGGicel:CELE_T08A9.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180996
WormBaseiT08A9.1 ; CE51575 ; WBGene00020334 ; epg-7

Phylogenomic databases

eggNOGiKOG4572 Eukaryota
ENOG410XSY4 LUCA
GeneTreeiENSGT00390000015871
HOGENOMiHOG000019311
InParanoidiQ22342
KOiK17589
OrthoDBi91906at2759

Enzyme and pathway databases

ReactomeiR-CEL-1632852 Macroautophagy

Gene expression databases

BgeeiWBGene00020334 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR040040 ATG11
IPR019460 Atg11_C
PANTHERiPTHR13222 PTHR13222, 1 hit
PfamiView protein in Pfam
PF10377 ATG11, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ22342_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22342
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: July 6, 2016
Last modified: December 11, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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