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Protein

T-box transcription factor tbx-9

Gene

tbx-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Appears to have partially redundant function to tbx-8.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi10 – 194T-boxPROSITE-ProRule annotationAdd BLAST185

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: WormBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: WormBase

GO - Biological processi

  • embryonic body morphogenesis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: WormBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Protein family/group databases

MoonDBiQ22289 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor tbx-9
Gene namesi
Name:tbx-9
ORF Names:T07C4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT07C4.6 ; CE36892 ; WBGene00006546 ; tbx-9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844721 – 292T-box transcription factor tbx-9Add BLAST292

Proteomic databases

PaxDbiQ22289
PRIDEiQ22289

Expressioni

Tissue specificityi

Expressed during morphogenesis in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells. First detected in the E cell at the 8 cell stage and its daughter Ea and Ep cells until the 24 cell stage. At the 24 cell stage detected in 5 cells including AB descendant cells and also the Ca and Cp cells. At the 200 cell stage, detected in two pairs of MS descendant cells. Thereafter detected in a subset of cells at each stage up to approximately the 400 cell stage, becoming undetectable just before morphogenesis. During morphogenesis detected in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells up until early L1 larval stage.1 Publication

Gene expression databases

BgeeiWBGene00006546 Expressed in 13 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

IntActiQ22289, 119 interactors
STRINGi6239.T07C4.6.1

Structurei

3D structure databases

ProteinModelPortaliQ22289
SMRiQ22289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000015836
InParanoidiQ22289
OMAiMIPLHSM
OrthoDBiEOG091G0RAB
PhylomeDBiQ22289

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q22289-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKVKVSIEG SQETLWKIFH AEVNEMIVTK NGRKLFPKLE YIVEGLDENK
60 70 80 90 100
LYAIMLQLQP VGESRFKFSG GKWQETGKAE KQVDAKKMWH ADGVRKGSDW
110 120 130 140 150
MWSSICFDRV KISNYSESNN ASMIYLNSMH KYIPVLTIYE SPSESPFCVP
160 170 180 190 200
QSSNQIVATA KFPHTEFIAV TAYQNQKITD LKIKHNSFAK GFRDGNLSRK
210 220 230 240 250
RRSPSYSDGS NSQSPSPKSR SPPEVAPLQS MPPINPFLFY FPHMLSENLP
260 270 280 290
VQFPFAFPFL SPLPSTPSSS SSELSIVKEE DQEVEEDIDI VG
Length:292
Mass (Da):33,045
Last modified:August 31, 2004 - v2
Checksum:iCE1424246959C787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019521 mRNA Translation: BAC66463.1
Z29443 Genomic DNA Translation: CAA82575.2
PIRiS41019
RefSeqiNP_499286.2, NM_066885.4
UniGeneiCel.9959

Genome annotation databases

EnsemblMetazoaiT07C4.6; T07C4.6; WBGene00006546
GeneIDi176449
KEGGicel:CELE_T07C4.6
UCSCiT07C4.6 c. elegans

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019521 mRNA Translation: BAC66463.1
Z29443 Genomic DNA Translation: CAA82575.2
PIRiS41019
RefSeqiNP_499286.2, NM_066885.4
UniGeneiCel.9959

3D structure databases

ProteinModelPortaliQ22289
SMRiQ22289
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ22289, 119 interactors
STRINGi6239.T07C4.6.1

Protein family/group databases

MoonDBiQ22289 Predicted

Proteomic databases

PaxDbiQ22289
PRIDEiQ22289

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT07C4.6; T07C4.6; WBGene00006546
GeneIDi176449
KEGGicel:CELE_T07C4.6
UCSCiT07C4.6 c. elegans

Organism-specific databases

CTDi176449
WormBaseiT07C4.6 ; CE36892 ; WBGene00006546 ; tbx-9

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000015836
InParanoidiQ22289
OMAiMIPLHSM
OrthoDBiEOG091G0RAB
PhylomeDBiQ22289

Miscellaneous databases

PROiPR:Q22289

Gene expression databases

BgeeiWBGene00006546 Expressed in 13 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBX9_CAEEL
AccessioniPrimary (citable) accession number: Q22289
Secondary accession number(s): Q86M50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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