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Entry version 162 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Segment polarity protein dishevelled homolog mig-5

Gene

mig-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:26795562). Functions redundantly with other dishevelled family members throughout development (PubMed:19298786, PubMed:25344071, PubMed:26460008, PubMed:26795562). During embryonic and larval development, controls cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells (PubMed:16899238, PubMed:26795562). In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the correct mitotic spindle orientation of the ABar blastomere division plane (PubMed:16899238, PubMed:25344071). Controls the polarity and the asymmetric localization of downstream components of the wnt/beta-catenin asymmetry pathway, and in particular, controls the asymmetric localization of the wnt receptor lin-17/Frizzled in ectodermal blast B cells (PubMed:16631156, PubMed:17196955, PubMed:19298786, PubMed:26795562). May act redundantly with dsh-2 to regulate the expression and nuclear localization of the beta-catenin homolog wrm-2, but alone seems to be required for the polarity of wrm-2 during the asymmetric cell division of hypodermal seam cells (PubMed:26795562). Also, maintains the polarity and migration of QL neuroblasts in larvae (PubMed:16899238). During the embryonic development of touch receptor neurons, may act redundantly with dsh-1, downstream of wnt signaling ligands and the wnt receptor lin-17/Frizzled, to direct the growth of neurites of touch receptor neurons towards the anterior of the body of the worm and towards the PLM touch receptor neuron and other tail neurons (PubMed:26460008). May play a role in the guidance of posterior D-type motor neuron axons along the anteroposterior axis (PubMed:19259273).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-201688 WNT mediated activation of DVL
R-CEL-2028269 Signaling by Hippo
R-CEL-4086400 PCP/CE pathway
R-CEL-4641258 Degradation of DVL
R-CEL-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CEL-5099900 WNT5A-dependent internalization of FZD4
R-CEL-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q22227

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog mig-5Curated
Alternative name(s):
Abnormal cell migration protein 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mig-5Imported
ORF Names:T05C12.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
T05C12.6a ; CE02318 ; WBGene00003241 ; mig-5
T05C12.6b ; CE25100 ; WBGene00003241 ; mig-5
T05C12.6c ; CE28076 ; WBGene00003241 ; mig-5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic and larval cell fate, polarity, division and migration defects (PubMed:16899238, PubMed:17196955, PubMed:26795562). In several lineages of the developing gonad 42.6% of hermaphrodites do not have either one or both distal tip cells, which results in the absence of the corresponding gonad arm, and germline proliferation defects in the male germ line (PubMed:16899238). Defects in hypodermal morphogenesis including disorganized dorsal cell intercalation, eventually resulting in 2-fold stage arrest, and failed ventral enclosure in some worms (PubMed:16899238). Cell polarity and migration defects including mitotic spindle misalignment, particularly in the ABar blastomere which results in the posterior cells of the blastomere adopting an alternate more anterior position (PubMed:16899238). Defective QL neuroblast migration with 100% of descendants migrating towards the anterior rather than the posterior of larvae (PubMed:16899238). Disrupted asymmetric cell divisions of hypodermal seam cells with the mislocalization and reduced expression of a wnt/beta catenin pathway component sys-1 and its negative regulator apr-1, and wrm-1 in daughter seam cells (PubMed:26795562). Irregular symmetric localization of lin-17/Frizzled in ectodermal blast B cells (PubMed:17196955).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004374911 – 672Segment polarity protein dishevelled homolog mig-5CuratedAdd BLAST672

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22227

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic and larval development (PubMed:16899238). Expressed in most embryonic cells during hypodermal morphogenesis, and in Z1 and Z4 distal tip precursor cells, in distal tips cells during gonadal migration and in the gonandal primordium, which become vulval precursor cells, during larval development (PubMed:16899238). Also expressed in hypodermal precursor cells P11 and P12 and their daughter cells P11.a, P11.p, P12.a and P12.p, and in the SDQL and PVM neurons which are derived from the QL neuroblast (PubMed:16899238). During larval development, expressed in blast B cells and its descendants, the QL cell and in cells in the nerve ring (PubMed:16631156).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003241 Expressed in 5 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-27038N

Protein interaction database and analysis system

More...
IntActi
Q22227, 99 interactors

Molecular INTeraction database

More...
MINTi
Q22227

STRING: functional protein association networks

More...
STRINGi
6239.T05C12.6a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q22227

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 91DIXPROSITE-ProRule annotationAdd BLAST83
Domaini226 – 294PDZPROSITE-ProRule annotationAdd BLAST69
Domaini427 – 501DEPPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi568 – 571Poly-ArgSequence analysis4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DEP domain is required for cell membrane localization.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DSH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3571 Eukaryota
ENOG410Y5G4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182903

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016057

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22227

Identification of Orthologs from Complete Genome Data

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OMAi
TFTEKCY

Database of Orthologous Groups

More...
OrthoDBi
474724at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22227

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.10.20.380, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10878 PTHR10878, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit
PF00778 DIX, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q22227-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPPCTSDCS QIKVFYYLDD ETTPYVSVIE AREGVATLGN FKNSFTKRGY
60 70 80 90 100
KYYAKELDPD IQREVKVELT TDSDRLRKSQ NGFYEIFLVS TPGYGTLPRN
110 120 130 140 150
SGTMTRPQRT ALDKRRRRSA DFDATPYSDA SLAPSTIVSR RAGEHLAELY
160 170 180 190 200
TSNSEDPYQY DEHTRRTGDD SSLYEPLAAR DMNKIYDDDR RRKKQKKERF
210 220 230 240 250
RRPYVPSTIS SATESSVNSG LPRILEIYLP MKNVPYLGLS VCTIDGHIFV
260 270 280 290 300
SEIAPEGAVE KDGRVNVGDQ ILQVNRVSFE ELSGPQAVRS LREAASSKRP
310 320 330 340 350
ITLYISKFAR GAPSEYDDPL ASMASETMPL DVGVWVETAV QNTEKMKALG
360 370 380 390 400
LDPQEQTATT IDDGTLPFTS TASDDEERML YDQRRNGIPR ALIEEAERKR
410 420 430 440 450
ENEQNEKIEQ LTEMIDPIIV VRSMARPDSG LAVKNRKWLK ILVPMSFIGR
460 470 480 490 500
DLVDWLVDHM ADIHNRKKAR IYAARLLAAG LIRHVVSKLT FTEKCYYVFG
510 520 530 540 550
DGILGNDRNS TDTTGTSGTT MRVEATTEVT YVGSPAPHAL AARVGRNIPH
560 570 580 590 600
RLETTTLSPV AHDQTWLRRR RDCESPMTND YASMVGESQI GMNPVGNYHV
610 620 630 640 650
FGTKNNHRQV PAPSQVTSSS LTNGSGGLGG PPPTPLSSTM VLAASPIQSQ
660 670
NAVNHDFDGE NSSNSRTRIL RT
Length:672
Mass (Da):75,018
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i198FA92312997CF6
GO
Isoform bImported (identifier: Q22227-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     624-672: GSGGLGGPPP...SNSRTRILRT → VTNSRKWWLR...SQPRFRRGEQ

Show »
Length:666
Mass (Da):75,091
Checksum:i21C4EB2D673ACD1F
GO
Isoform cImported (identifier: Q22227-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-340: Missing.
     624-672: GSGGLGGPPP...SNSRTRILRT → VTNSRKWWLR...SQPRFRRGEQ

Show »
Length:625
Mass (Da):70,680
Checksum:i63FB8132B1E25CC2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058543300 – 340Missing in isoform c. CuratedAdd BLAST41
Alternative sequenceiVSP_058544624 – 672GSGGL…RILRT → VTNSRKWWLRRPSADSSIQY YGSSSFSDSVAERSQPRFRR GEQ in isoform b and isoform c. CuratedAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF063244 mRNA Translation: AAC16434.1
AF070920 mRNA Translation: AAC24231.1
BX284602 Genomic DNA Translation: CAA91307.1
BX284602 Genomic DNA Translation: CAB61022.1
BX284602 Genomic DNA Translation: CAC42334.1

Protein sequence database of the Protein Information Resource

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PIRi
T24507
T43171
T43211

NCBI Reference Sequences

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RefSeqi
NP_001022316.1, NM_001027145.2 [Q22227-1]
NP_001022317.1, NM_001027146.2 [Q22227-2]
NP_001022318.1, NM_001027147.2 [Q22227-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T05C12.6a; T05C12.6a; WBGene00003241 [Q22227-1]
T05C12.6b; T05C12.6b; WBGene00003241 [Q22227-2]
T05C12.6c; T05C12.6c; WBGene00003241 [Q22227-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
174317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T05C12.6

UCSC genome browser

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UCSCi
T05C12.6b c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063244 mRNA Translation: AAC16434.1
AF070920 mRNA Translation: AAC24231.1
BX284602 Genomic DNA Translation: CAA91307.1
BX284602 Genomic DNA Translation: CAB61022.1
BX284602 Genomic DNA Translation: CAC42334.1
PIRiT24507
T43171
T43211
RefSeqiNP_001022316.1, NM_001027145.2 [Q22227-1]
NP_001022317.1, NM_001027146.2 [Q22227-2]
NP_001022318.1, NM_001027147.2 [Q22227-3]

3D structure databases

SMRiQ22227
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-27038N
IntActiQ22227, 99 interactors
MINTiQ22227
STRINGi6239.T05C12.6a

Proteomic databases

PaxDbiQ22227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT05C12.6a; T05C12.6a; WBGene00003241 [Q22227-1]
T05C12.6b; T05C12.6b; WBGene00003241 [Q22227-2]
T05C12.6c; T05C12.6c; WBGene00003241 [Q22227-3]
GeneIDi174317
KEGGicel:CELE_T05C12.6
UCSCiT05C12.6b c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174317
WormBaseiT05C12.6a ; CE02318 ; WBGene00003241 ; mig-5
T05C12.6b ; CE25100 ; WBGene00003241 ; mig-5
T05C12.6c ; CE28076 ; WBGene00003241 ; mig-5

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00950000182903
HOGENOMiHOG000016057
InParanoidiQ22227
OMAiTFTEKCY
OrthoDBi474724at2759
PhylomeDBiQ22227

Enzyme and pathway databases

ReactomeiR-CEL-201688 WNT mediated activation of DVL
R-CEL-2028269 Signaling by Hippo
R-CEL-4086400 PCP/CE pathway
R-CEL-4641258 Degradation of DVL
R-CEL-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CEL-5099900 WNT5A-dependent internalization of FZD4
R-CEL-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828 Clathrin-mediated endocytosis
SignaLinkiQ22227

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q22227

Gene expression databases

BgeeiWBGene00003241 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00778 DIX, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMIG5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22227
Secondary accession number(s): G5EC49, O76471, Q95ZQ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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