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Entry version 173 (16 Oct 2019)
Sequence version 2 (23 Sep 2008)
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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3

Gene

plc-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca2+ oscillations via IP3-mediated activation of IP3 receptor itr-1 (PubMed:15194811). In intestinal epithelial cells, regulates Ca2+ oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation of itr-1 and probably by activating TRPM channels gon-2 and gtl-1 by reducing PIP2 levels (PubMed:19923421, PubMed:16186564). By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:19380113). By triggering Ca2+ transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, involved in avoidance behavior in response to nose touch (PubMed:19730689). Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and receptor let-23 and upstream of tpa-1 but not itr-1 (PubMed:17891142). During embryogenesis, may play an role in epidermal morphogenesis together with plc-1 (PubMed:18369461). Probably downstream of receptor daf-2, regulates male-sex muscle excitability in the absence of food (PubMed:18604269).Curated8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei367PROSITE-ProRule annotation1
Active sitei419PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-114604 GPVI-mediated activation cascade
R-CEL-1169408 ISG15 antiviral mechanism
R-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
R-CEL-186763 Downstream signal transduction
R-CEL-202433 Generation of second messenger molecules
R-CEL-210990 PECAM1 interactions
R-CEL-212718 EGFR interacts with phospholipase C-gamma
R-CEL-5607764 CLEC7A (Dectin-1) signaling
R-CEL-5654219 Phospholipase C-mediated cascade: FGFR1
R-CEL-5654221 Phospholipase C-mediated cascade, FGFR2
R-CEL-5654227 Phospholipase C-mediated cascade, FGFR3
R-CEL-5654228 Phospholipase C-mediated cascade, FGFR4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q22070

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3Curated (EC:3.1.4.11UniRule annotation)
Alternative name(s):
Phosphoinositide phospholipase C-gamma plc-3Curated
Phospholipase C-gamma plc-3Curated
Short name:
PLC-gamma plc-3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:plc-3Imported
ORF Names:T01E8.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
T01E8.3 ; CE42905 ; WBGene00004038 ; plc-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes sterility resulting from impaired spermatheca dilatation causing a defect in ovulation, and a severe decrease in sheath cell basal and peak ovulatory contractions (PubMed:15194811, PubMed:18369461). The few embryos laid are arrested at the embryonic stage (PubMed:18369461). Cycles of posterior body wall muscle contractions are prolonged and arrhythmic resulting in a defecation defect (PubMed:16186564). Ca2+ oscillations in intestinal cells are arrhythmic and the whole cell current amplitude is severely reduced (PubMed:16186564, PubMed:19923421). RNAi-mediated knockdown in males causes an increase in spontaneous muscle seizures in the absence of food in an unc-103 mutant background (PubMed:18604269). Ca2+ transient increase and avoidance behavior are defective in response to nose touch but not to benzaldehyde (PubMed:19730689). nlp-29 expression is abrogated following fungal infection by D.coniospora and severely reduced following physical injury (PubMed:19380113).7 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004374631 – 13501-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3CuratedAdd BLAST1350

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q22070

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22070

PeptideAtlas

More...
PeptideAtlasi
Q22070

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in intestine, isthmus of the pharynx, proximal gonad sheath cells, spermatheca and uterine sheath cells (PubMed:15194811, PubMed:16186564). In males, expressed in the valve cell, the vas deferens and retractor and ventral protactor muscles (PubMed:15958491, PubMed:18604269).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004038 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q22070, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T01E8.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q22070

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini352 – 503PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST152
Domaini605 – 704SH2 1PROSITE-ProRule annotationAdd BLAST100
Domaini715 – 804SH2 2PROSITE-ProRule annotationAdd BLAST90
Domaini832 – 890SH3PROSITE-ProRule annotationAdd BLAST59
Domaini855 – 960PHPROSITE-ProRule annotationAdd BLAST106
Domaini982 – 1092PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST111
Domaini1098 – 1203C2PROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1264 Eukaryota
ENOG410XPXE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169016

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230864

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22070

KEGG Orthology (KO)

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KOi
K01116

Identification of Orthologs from Complete Genome Data

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OMAi
RYQFNED

Database of Orthologous Groups

More...
OrthoDBi
368239at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22070

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09932 SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341 SH2_N-SH2_PLC_gamma_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR016279 PLC-gamma
IPR035023 PLC-gamma_C-SH2
IPR035024 PLC-gamma_N-SH2
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10336 PTHR10336, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000952 PLC-gamma, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390 PHPHLIPASEC
PR00401 SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF51695 SSF51695, 1 hit
SSF55550 SSF55550, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q22070-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHGSLGPSS SSRKTTVTST AGSVHLHHRS SNGFSTASRA QLNRHNEMDF
60 70 80 90 100
GKMFAAMEKG HKVCKIAVLK KWDPAYKQLT LDRYSRQIFL TKLELSAVRN
110 120 130 140 150
KPTILDIRQI REVQTLNYKL NTIKVDDKWK KDREIVNFDS KAILIISYGM
160 170 180 190 200
GFALSYWILL FESEDACKLW SQGLHNLMMD TRDRDSSPHP LRIERFLHKH
210 220 230 240 250
FLSLMSPAND AVARKHMKPF VQTSLQFKVQ SDQLQQVTED QMNSDQFSFA
260 270 280 290 300
SRQLIHVPEL FSSRFADLAE KHERKGLVVT FQNFLRFLDG KQFDELASNR
310 320 330 340 350
TRALEFLNRY FQEDQAYFGD RNEPSMTVFE FCDFLFSREN SLWDPTNEKV
360 370 380 390 400
THDMSRPLSH YWIASSHNTY LTGDQLRSES SLDCYAQALL MGCRCIELDC
410 420 430 440 450
WDGQKKPGSA EFIDIVIYHG YTMTSKILLR DVLHVIRHYA FVTSEYPVIL
460 470 480 490 500
SIEDNCSVPA QRLLAQELKD ILGDYLLTQP ANREEKQLPS PAALKKKIIV
510 520 530 540 550
KHKKLPIESE DLAAVVKTDE FQDTEIISRE CVKKGILMVK NNNSHEWTSH
560 570 580 590 600
VFILFPDRLC YLIQTADPEN PNDDTVSVSG DEEREEETPS GFGVKPEEMH
610 620 630 640 650
VTEEWFHGRC ERDEAKKRIL EHKEKGNGLF MIRDSNLFIG DFSLSILHDG
660 670 680 690 700
KVHHVRIRSK IIDKEKKYYF MDNKVCDTLY ELVSYYTRHY LTTAHFKMVL
710 720 730 740 750
TIPCPQPQPH LNQPWFSATA DKEKAEELLS LVPEDGAFLI RTSSTDSSVY
760 770 780 790 800
VLSLKVDGEF WHYRLKRDGR IFVVNQKVFE NLNQIVEFYA NREFVRGISL
810 820 830 840 850
RFPVNEKDIS HLTAELAEAR TPGCYMDLKD LDKEVQARAL RPYRGTADDE
860 870 880 890 900
LSFPANVIIT VLRKEEGLWR GRYGSLTGWF PSAHVQEILP EKVSTSETSN
910 920 930 940 950
YNTIELAGTL IERIHDADRP NVIRISQSNQ HWMNKQYYLL AASSSEEADG
960 970 980 990 1000
WQNNLFELTR SVNTKMSILR TKEKEKRIAA ELSNLVVYCQ AVPFDPAHIY
1010 1020 1030 1040 1050
NDAFYEMCSF VEGKLDKLVE KGLLPFNSRK LSRVYPNGSR ITSNNYSPVP
1060 1070 1080 1090 1100
MWNAGCHMVA LNYQTGDKPM QLNQGKFLAN GRCGYLLKPD YMLTDDFDPT
1110 1120 1130 1140 1150
NTEKFATAYP IRLNVQVIGG RHLSRKDKNK GICSPFVEIE IIGMPCDTKV
1160 1170 1180 1190 1200
FQTKTIASNG LNPIWNQTFT FEIQCPEVAL IRFHVEDGDF VGPKTDPFIG
1210 1220 1230 1240 1250
QAVFPVDSIR CGFRSVPLKN QYSEELELSS LLVDVQMCSR EGTQLIRSSS
1260 1270 1280 1290 1300
HFLQASRLAP VFAHRKITNG DSIPREMAPR LRTSATDRSL DSPTNSESRA
1310 1320 1330 1340 1350
TLLSGQRGSQ DSMDSAAETS SIASGTISSR DGKKKQNWLK KFSFGKSSKS
Length:1,350
Mass (Da):154,574
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F636BE56E7F58F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA88745.2

NCBI Reference Sequences

More...
RefSeqi
NP_496205.2, NM_063804.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T01E8.3.1; T01E8.3.1; WBGene00004038

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T01E8.3

UCSC genome browser

More...
UCSCi
T01E8.3 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA88745.2
RefSeqiNP_496205.2, NM_063804.4

3D structure databases

SMRiQ22070
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ22070, 2 interactors
STRINGi6239.T01E8.3

Proteomic databases

EPDiQ22070
PaxDbiQ22070
PeptideAtlasiQ22070

Genome annotation databases

EnsemblMetazoaiT01E8.3.1; T01E8.3.1; WBGene00004038
GeneIDi174586
KEGGicel:CELE_T01E8.3
UCSCiT01E8.3 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174586
WormBaseiT01E8.3 ; CE42905 ; WBGene00004038 ; plc-3

Phylogenomic databases

eggNOGiKOG1264 Eukaryota
ENOG410XPXE LUCA
GeneTreeiENSGT00940000169016
HOGENOMiHOG000230864
InParanoidiQ22070
KOiK01116
OMAiRYQFNED
OrthoDBi368239at2759
PhylomeDBiQ22070

Enzyme and pathway databases

ReactomeiR-CEL-114604 GPVI-mediated activation cascade
R-CEL-1169408 ISG15 antiviral mechanism
R-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
R-CEL-186763 Downstream signal transduction
R-CEL-202433 Generation of second messenger molecules
R-CEL-210990 PECAM1 interactions
R-CEL-212718 EGFR interacts with phospholipase C-gamma
R-CEL-5607764 CLEC7A (Dectin-1) signaling
R-CEL-5654219 Phospholipase C-mediated cascade: FGFR1
R-CEL-5654221 Phospholipase C-mediated cascade, FGFR2
R-CEL-5654227 Phospholipase C-mediated cascade, FGFR3
R-CEL-5654228 Phospholipase C-mediated cascade, FGFR4
SignaLinkiQ22070

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q22070

Gene expression databases

BgeeiWBGene00004038 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

CDDicd09932 SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341 SH2_N-SH2_PLC_gamma_like, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR016279 PLC-gamma
IPR035023 PLC-gamma_C-SH2
IPR035024 PLC-gamma_N-SH2
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PIRSFiPIRSF000952 PLC-gamma, 1 hit
PRINTSiPR00390 PHPHLIPASEC
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF51695 SSF51695, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCG_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22070
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: September 23, 2008
Last modified: October 16, 2019
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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