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Entry version 124 (26 Feb 2020)
Sequence version 2 (05 Jul 2005)
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Protein

Probable 3',5'-cyclic phosphodiesterase pde-4

Gene

pde-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP (PubMed:29033363).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei407Proton donorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi411Divalent metal cation 1By similarity1
Metal bindingi447Divalent metal cation 1By similarity1
Metal bindingi448Divalent metal cation 1By similarity1
Metal bindingi448Divalent metal cation 2By similarity1
Metal bindingi565Divalent metal cation 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-180024 DARPP-32 events
R-CEL-418555 G alpha (s) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-4 (EC:3.1.4.17)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pde-4
ORF Names:R153.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
R153.1a ; CE02038 ; WBGene00020114 ; pde-4
R153.1b ; CE28641 ; WBGene00020114 ; pde-4
R153.1c ; CE32060 ; WBGene00020114 ; pde-4
R153.1d ; CE33438 ; WBGene00020114 ; pde-4
R153.1e ; CE33439 ; WBGene00020114 ; pde-4
R153.1f ; CE33440 ; WBGene00020114 ; pde-4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988471 – 674Probable 3',5'-cyclic phosphodiesterase pde-4Add BLAST674

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q22000

PeptideAtlas

More...
PeptideAtlasi
Q22000

PRoteomics IDEntifications database

More...
PRIDEi
Q22000

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in dorsal D (DD) motor neurons and several other neurons at the L1 stage. Expression in DD neurons decreases gradually beginning in the late L1 stage. Highly expressed in adult ventral D (VD) motor neurons, but diminished in adult DD motor neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00020114 Expressed in multi-cellular organism and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.R153.1d

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q22000

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini328 – 660PDEasePROSITE-ProRule annotationAdd BLAST333

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3689 Eukaryota
ENOG410XRI7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155190

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005940_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q22000

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARYSHNR

Database of Orthologous Groups

More...
OrthoDBi
904682at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q22000

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00077 HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003607 HD/PDEase_dom
IPR040844 PDE4_UCR
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18100 PDE4_UCR, 1 hit
PF00233 PDEase_I, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00387 PDIESTERASE1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00471 HDc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform d (identifier: Q22000-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRRRGSSSS SSAAGGSGGG GGFGFSSLRR ELHLHNFFRT SSPSASSTSR
60 70 80 90 100
TPPAALPPRT SAVTIPGSNH KLTSSASSYH PPRELTVSTF SAGSATAADG
110 120 130 140 150
LGGAHLTPSL SSSVHARRES FLYRASDDLR EASSLRPVSR ASSIASNEHG
160 170 180 190 200
HGDDLIVTPF AQLLASLRNV RSNLISITNI QNSDDSRHAN RSAKRPPLHN
210 220 230 240 250
IELPDDVVHC AHDTLEELDW CLDQLETIQT HRSVSEMASS KFRKMLNKEL
260 270 280 290 300
SHFAESSKSG TQVSKFLITT YMDKEEDEPS IEIEVPTEVQ GPSTSGPMTL
310 320 330 340 350
SILKKAQTAA MNKISGVRKL RAPSHDGHVP EYGVNCAREI AVHMQRLDDW
360 370 380 390 400
GPDVFKIDEL SKNHSLTVVT FSLLRQRNLF KTFEIHQSTL VTYLLNLEHH
410 420 430 440 450
YRNNHYHNFI HAADVAQSMH VLLMSPVLTE VFTDLEVLAA IFAGAVHDVD
460 470 480 490 500
HPGFTNQYLI NSNNELAIMY NDESVLEQHH LAVAFKLLQD SNCDFLANLS
510 520 530 540 550
RKQRLQFRKI VIDMVLATDM SKHMSLLADL KTMVEAKKVA GNNVIVLDKY
560 570 580 590 600
NDKIQVLQSM IHLADLSNPT KPIELYQQWN QRIMEEYWRQ GDKEKELGLE
610 620 630 640 650
ISPMCDRGNV TIEKSQVGFI DYIVHPLYET WADLVYPDAQ NILDQLEENR
660 670
EWYQSRIPEE PDTARTVTED DEHK
Length:674
Mass (Da):75,389
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87BA310BE45DBD30
GO
Isoform a (identifier: Q22000-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.
     126-150: SDDLREASSLRPVSRASSIASNEHG → MSISLINNNNRSVRRKFGESGFTLR

Show »
Length:549
Mass (Da):62,904
Checksum:iDF2EE6F03925DE87
GO
Isoform b (identifier: Q22000-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-91: VTIPGSNHKLTSSASSYHPPRELTVSTFS → MNGVARRKQFKLRPWQSTALPSRHDHYSC

Show »
Length:612
Mass (Da):69,498
Checksum:i5E75F83B7D539255
GO
Isoform c (identifier: Q22000-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     76-90: ASSYHPPRELTVSTF → MTSRRHTVWFVPGSR

Show »
Length:599
Mass (Da):67,932
Checksum:i30F3EC75C7A51CA6
GO
Isoform e (identifier: Q22000-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-91: SRTPPAALPP...PRELTVSTFS → MCGSRRHLRR...LPSRHDHYSC

Show »
Length:626
Mass (Da):71,167
Checksum:i548A274EC8D470D6
GO
Isoform f (identifier: Q22000-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-158: HGDDLIVT → YVILYIFL
     159-674: Missing.

Show »
Length:158
Mass (Da):16,407
Checksum:i119F39EF1F6BEC58
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q2V4U0Q2V4U0_CAEEL
Phosphodiesterase
pde-4 CELE_R153.1, R153.1
673Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S6FCW6S6FCW6_CAEEL
Phosphodiesterase
pde-4 CELE_R153.1, R153.1
624Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0143451 – 125Missing in isoform a. CuratedAdd BLAST125
Alternative sequenceiVSP_0143461 – 75Missing in isoform c. CuratedAdd BLAST75
Alternative sequenceiVSP_0143471 – 62Missing in isoform b. CuratedAdd BLAST62
Alternative sequenceiVSP_0143481 – 48Missing in isoform e. CuratedAdd BLAST48
Alternative sequenceiVSP_01434949 – 91SRTPP…VSTFS → MCGSRRHLRRNEDGMNGVAR RKQFKLRPWQSTALPSRHDH YSC in isoform e. CuratedAdd BLAST43
Alternative sequenceiVSP_01435063 – 91VTIPG…VSTFS → MNGVARRKQFKLRPWQSTAL PSRHDHYSC in isoform b. CuratedAdd BLAST29
Alternative sequenceiVSP_01435176 – 90ASSYH…TVSTF → MTSRRHTVWFVPGSR in isoform c. CuratedAdd BLAST15
Alternative sequenceiVSP_014352126 – 150SDDLR…SNEHG → MSISLINNNNRSVRRKFGES GFTLR in isoform a. CuratedAdd BLAST25
Alternative sequenceiVSP_014353151 – 158HGDDLIVT → YVILYIFL in isoform f. Curated8
Alternative sequenceiVSP_014354159 – 674Missing in isoform f. CuratedAdd BLAST516

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081170 Genomic DNA Translation: CCD69643.1
FO081170 Genomic DNA Translation: CCD69647.1
FO081170 Genomic DNA Translation: CCD69649.1
FO081170 Genomic DNA Translation: CCD69644.1
FO081170 Genomic DNA Translation: CCD69648.1
FO081170 Genomic DNA Translation: CCD69645.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16769

NCBI Reference Sequences

More...
RefSeqi
NP_495600.1, NM_063199.3 [Q22000-5]
NP_495601.1, NM_063200.1 [Q22000-2]
NP_871944.1, NM_182144.3 [Q22000-4]
NP_871945.1, NM_182145.3 [Q22000-1]
NP_871946.1, NM_182146.3 [Q22000-3]
NP_871947.1, NM_182147.3 [Q22000-6]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R153.1a.1; R153.1a.1; WBGene00020114 [Q22000-2]
R153.1b.1; R153.1b.1; WBGene00020114 [Q22000-5]
R153.1c.1; R153.1c.1; WBGene00020114 [Q22000-4]
R153.1d.1; R153.1d.1; WBGene00020114 [Q22000-1]
R153.1e.1; R153.1e.1; WBGene00020114 [Q22000-3]
R153.1f.1; R153.1f.1; WBGene00020114 [Q22000-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174235

UCSC genome browser

More...
UCSCi
R153.1b c. elegans [Q22000-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081170 Genomic DNA Translation: CCD69643.1
FO081170 Genomic DNA Translation: CCD69647.1
FO081170 Genomic DNA Translation: CCD69649.1
FO081170 Genomic DNA Translation: CCD69644.1
FO081170 Genomic DNA Translation: CCD69648.1
FO081170 Genomic DNA Translation: CCD69645.1
PIRiT16769
RefSeqiNP_495600.1, NM_063199.3 [Q22000-5]
NP_495601.1, NM_063200.1 [Q22000-2]
NP_871944.1, NM_182144.3 [Q22000-4]
NP_871945.1, NM_182145.3 [Q22000-1]
NP_871946.1, NM_182146.3 [Q22000-3]
NP_871947.1, NM_182147.3 [Q22000-6]

3D structure databases

SMRiQ22000
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.R153.1d

Proteomic databases

PaxDbiQ22000
PeptideAtlasiQ22000
PRIDEiQ22000

Genome annotation databases

EnsemblMetazoaiR153.1a.1; R153.1a.1; WBGene00020114 [Q22000-2]
R153.1b.1; R153.1b.1; WBGene00020114 [Q22000-5]
R153.1c.1; R153.1c.1; WBGene00020114 [Q22000-4]
R153.1d.1; R153.1d.1; WBGene00020114 [Q22000-1]
R153.1e.1; R153.1e.1; WBGene00020114 [Q22000-3]
R153.1f.1; R153.1f.1; WBGene00020114 [Q22000-6]
GeneIDi174235
UCSCiR153.1b c. elegans [Q22000-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174235
WormBaseiR153.1a ; CE02038 ; WBGene00020114 ; pde-4
R153.1b ; CE28641 ; WBGene00020114 ; pde-4
R153.1c ; CE32060 ; WBGene00020114 ; pde-4
R153.1d ; CE33438 ; WBGene00020114 ; pde-4
R153.1e ; CE33439 ; WBGene00020114 ; pde-4
R153.1f ; CE33440 ; WBGene00020114 ; pde-4

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00940000155190
HOGENOMiCLU_005940_8_0_1
InParanoidiQ22000
OMAiARYSHNR
OrthoDBi904682at2759
PhylomeDBiQ22000

Enzyme and pathway databases

ReactomeiR-CEL-180024 DARPP-32 events
R-CEL-418555 G alpha (s) signalling events

Miscellaneous databases

Protein Ontology

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PROi
PR:Q22000

Gene expression databases

BgeeiWBGene00020114 Expressed in multi-cellular organism and 3 other tissues

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR040844 PDE4_UCR
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF18100 PDE4_UCR, 1 hit
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE4_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q22000
Secondary accession number(s): Q86NE7
, Q86NE8, Q86NE9, Q8IFZ3, Q95ZQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 5, 2005
Last modified: February 26, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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