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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi382 – 389ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEG203122:G1G67-406-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Sde_0387
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeSaccharophagus
Proteomesi
  • UP000001947 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei74 – 94HelicalUniRule annotationAdd BLAST21
Transmembranei156 – 173HelicalUniRule annotationAdd BLAST18
Transmembranei177 – 199HelicalUniRule annotationAdd BLAST23
Transmembranei264 – 284HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716491 – 586Lipid A export ATP-binding/permease protein MsbAAdd BLAST586

Proteomic databases

PRIDEiQ21NS8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi203122.Sde_0387

Structurei

3D structure databases

ProteinModelPortaliQ21NS8
SMRiQ21NS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 317ABC transmembrane type-1UniRule annotationAdd BLAST291
Domaini349 – 583ABC transporterUniRule annotationAdd BLAST235

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA
KOiK11085
OMAiGDLMNRI
OrthoDBiPOG091H00DB

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q21NS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPAKPTSV ESYKRLLSYA FKYKAYFIIS FIGFGVFAAM EAQLINILEY
60 70 80 90 100
FVDRLEGRPS APVLGLSADV TSSLWFVPIS VVVLSIIRGI GAYFGNFYMS
110 120 130 140 150
LVGLNVITNL RRQIFSQMIY LPQSFYDTKN SGELISLLVY NIEQVTGSVT
160 170 180 190 200
NAVKTLFRDG MSVAWFLAMM LIINWKLTLA FICVAPVLGG LMYIASKYFR
210 220 230 240 250
KVSHKIQSAV GRVSHVATES IQGIKLVKSY GGEKYELDRF NDATNQNLHY
260 270 280 290 300
GTKFERVSAF QTPVLHIVLA LALAVTFYLI MILWDSDSSK AVVYATYAAA
310 320 330 340 350
IAKPFRQLTK INSIIQKGLA AADTIFEVLD LQAEPNSGQQ KLNAPKGRVE
360 370 380 390 400
LKDVHFGYNQ DTPALNGISF AIEPGQTVAL VGSSGSGKST IVSLLLRFYD
410 420 430 440 450
NQQGSITIDG TPIQSLELHN LREHIALVNQ QTILFNDTIA ANIAYGSEHI
460 470 480 490 500
DEARIQDAAK QANAHDFIMA LPNGYQTPAG EDGSRLSGGQ RQRIAIARAL
510 520 530 540 550
YKNAPILILD EATSALDNES EKQIQSALDE LKQGRTTLVI AHRLSTIENA
560 570 580
DTILVMDNGR IVEAGNHQTL LDRSGVYANL YHSQFS
Length:586
Mass (Da):64,540
Last modified:April 18, 2006 - v1
Checksum:i63E61926EADC0385
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA Translation: ABD79651.1
RefSeqiWP_011466875.1, NC_007912.1

Genome annotation databases

EnsemblBacteriaiABD79651; ABD79651; Sde_0387
KEGGisde:Sde_0387

Similar proteinsi

Entry informationi

Entry nameiMSBA_SACD2
AccessioniPrimary (citable) accession number: Q21NS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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