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UniProtKB - Q21926 (SYIC_CAEEL)
Protein
Isoleucine--tRNA ligase, cytoplasmic
Gene
iars-1
Organism
Caenorhabditis elegans
Status
Functioni
Catalytic activityi
- EC:6.1.1.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 604 | ATPBy similarity | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- isoleucine-tRNA ligase activity Source: GO_Central
- tRNA binding Source: InterPro
GO - Biological processi
- isoleucyl-tRNA aminoacylation Source: GO_Central
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)Alternative name(s): Isoleucyl-tRNA synthetase Short name: IleRS |
Gene namesi | ORF Names:R11A8.6Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | R11A8.6 ; CE06304 ; WBGene00002152 ; iars-1 |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000098599 | 1 – 1141 | Isoleucine--tRNA ligase, cytoplasmicAdd BLAST | 1141 |
Proteomic databases
EPDi | Q21926 |
PaxDbi | Q21926 |
PeptideAtlasi | Q21926 |
Expressioni
Gene expression databases
Bgeei | WBGene00002152, Expressed in material anatomical entity and 5 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 43028, 15 interactors |
IntActi | Q21926, 1 interactor |
MINTi | Q21926 |
STRINGi | 6239.R11A8.6.1 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 50 – 60 | 'HIGH' regionAdd BLAST | 11 | |
Motifi | 601 – 605 | 'KMSKS' region | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG0434, Eukaryota |
GeneTreei | ENSGT00550000074921 |
HOGENOMi | CLU_001493_1_1_1 |
InParanoidi | Q21926 |
OMAi | KMMAPFT |
OrthoDBi | 59501at2759 |
PhylomeDBi | Q21926 |
Family and domain databases
CDDi | cd07961, Anticodon_Ia_Ile_ABEc, 1 hit |
Gene3Di | 3.40.50.620, 2 hits |
HAMAPi | MF_02003, Ile_tRNA_synth_type2, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR033709, Anticodon_Ile_ABEc IPR002301, Ile-tRNA-ligase IPR023586, Ile-tRNA-ligase_type2 IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR42780, PTHR42780, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 1 hit |
PRINTSi | PR00984, TRNASYNTHILE |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00392, ileS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
i Sequence
Sequence statusi: Complete.
Q21926-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGLSTVPDN INFAREEDKV AQKWQDENTF QRSVELSKDR PHFTFYDGPP
60 70 80 90 100
FATGLPHYGH MLTSTIKDVV GRWAHQNGHY VERRFGWDTH GLPVEYEIDK
110 120 130 140 150
TLGISGPQDV MKMGIANYNN ECRKIVMRYS GEWEKTMGRL GRWVDFKHDY
160 170 180 190 200
KTLYPWFMES VWWAFSELHK KGLVYKGVKV MPFSTACSTP LSNFEAGQNY
210 220 230 240 250
KDVVDPAVFV GFKLLDCPNR QLVAWTTTPW TLPSNLALVV HPDMLYVVTK
260 270 280 290 300
DKTTGIEYVV LEERLGELKN DNLEVIEKLA GSQLKDLRYE PLFPYFAYMR
310 320 330 340 350
EERNAFRVLN DTFVTSDSGT GVVHQAPYFG EIDFQVCVAN GVIAKDQKMI
360 370 380 390 400
CPVDESGKYT SEVPDYQGVY VKDADKLIIK RLKEMGNLVR QAEVKHSYPF
410 420 430 440 450
CWRSDTPLLY KAVPSWFINV ETLIPRLLAN NDETYWVPAF VKEKRFANWL
460 470 480 490 500
RDARDWAVSR NRFWGTPINL WVSEDGEEVV CVGSIAELEE LSGQKITDLH
510 520 530 540 550
RESVDDVTIP SRSGRGVLKR VSEVFDCWFE SGSMPYAQNH YPFENRKIFE
560 570 580 590 600
DNFPADFIAE GIDQTRGWFY TLLVLSTALF NKPPFKNLIC NGLVLASDGA
610 620 630 640 650
KMSKSKKNYP DPMLIVNKYG ADALRLYLIN SPVVRGENLR FREEGVRDLL
660 670 680 690 700
KDVFLPWFNA YRFFVQNVQA YEHETGNVFD MNVHVASENV MDRWIESFTN
710 720 730 740 750
SLVAFVRKEM DSYRLYAVVG PLTKFFDTLT NIYIRLNRKR VKGDNGLHEQ
760 770 780 790 800
HHALAALGRV LILIVRLMAP FTPFFCEYIW LNLKKVIGST EESVHFLMLP
810 820 830 840 850
KPDESLIDET VERRVEVMRN VIDLVRLVRD REGLAVKYPL KEMIVINRDS
860 870 880 890 900
QFLEDVKSLE SYILLELNVR KLTVSQDKQK YGITLKAEPN FKILGARLKG
910 920 930 940 950
EQKKVADYLK NQITESELEK FLLEGKLTVL GHELSSEEVA VSYAAGSDQG
960 970 980 990 1000
HGYKTHSDAK TIVMIDTTED ESLIEEGLCR EVTNRVQRLR KQAKLVSTDT
1010 1020 1030 1040 1050
AHVHIVVSPA DSQLAKVVAA KLNDIVSATG TPIKLGSPPA AAKAPTATSK
1060 1070 1080 1090 1100
SAIKDSEVEL WLFAEGDSFD GITVVDGSKK VRVHVKTEKE HLKGYADLLY
1110 1120 1130 1140
HVRSALDLWN GKIALKNVDG SAVHPTVDVT SLVGQTLQLV R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z70310 Genomic DNA Translation: CAA94369.1 |
PIRi | T24176 |
RefSeqi | NP_501914.1, NM_069513.4 |
Genome annotation databases
EnsemblMetazoai | R11A8.6.1; R11A8.6.1; WBGene00002152 R11A8.6.2; R11A8.6.2; WBGene00002152 |
UCSCi | R11A8.6, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z70310 Genomic DNA Translation: CAA94369.1 |
PIRi | T24176 |
RefSeqi | NP_501914.1, NM_069513.4 |
3D structure databases
SMRi | Q21926 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 43028, 15 interactors |
IntActi | Q21926, 1 interactor |
MINTi | Q21926 |
STRINGi | 6239.R11A8.6.1 |
Proteomic databases
EPDi | Q21926 |
PaxDbi | Q21926 |
PeptideAtlasi | Q21926 |
Genome annotation databases
EnsemblMetazoai | R11A8.6.1; R11A8.6.1; WBGene00002152 R11A8.6.2; R11A8.6.2; WBGene00002152 |
UCSCi | R11A8.6, c. elegans |
Organism-specific databases
WormBasei | R11A8.6 ; CE06304 ; WBGene00002152 ; iars-1 |
Phylogenomic databases
eggNOGi | KOG0434, Eukaryota |
GeneTreei | ENSGT00550000074921 |
HOGENOMi | CLU_001493_1_1_1 |
InParanoidi | Q21926 |
OMAi | KMMAPFT |
OrthoDBi | 59501at2759 |
PhylomeDBi | Q21926 |
Miscellaneous databases
PROi | PR:Q21926 |
Gene expression databases
Bgeei | WBGene00002152, Expressed in material anatomical entity and 5 other tissues |
Family and domain databases
CDDi | cd07961, Anticodon_Ia_Ile_ABEc, 1 hit |
Gene3Di | 3.40.50.620, 2 hits |
HAMAPi | MF_02003, Ile_tRNA_synth_type2, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR033709, Anticodon_Ile_ABEc IPR002301, Ile-tRNA-ligase IPR023586, Ile-tRNA-ligase_type2 IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR42780, PTHR42780, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 1 hit |
PRINTSi | PR00984, TRNASYNTHILE |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00392, ileS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYIC_CAEEL | |
Accessioni | Q21926Primary (citable) accession number: Q21926 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families