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Entry version 111 (07 Oct 2020)
Sequence version 2 (16 Apr 2014)
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Protein

Uncharacterized protein R09E10.5

Gene

R09E10.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein R09E10.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:R09E10.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
R09E10.5 ; CE48460 ; WBGene00011175

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1326ExtracellularSequence analysisAdd BLAST1301
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1327 – 1347HelicalSequence analysisAdd BLAST21
Topological domaini1348 – 1437CytoplasmicSequence analysisAdd BLAST90

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001429726 – 1437Uncharacterized protein R09E10.5Add BLAST1412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi364N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi492N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi676N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi914N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21874

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21874

PeptideAtlas

More...
PeptideAtlasi
Q21874

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q21874

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011175, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.R09E10.5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini193 – 356NIDOPROSITE-ProRule annotationAdd BLAST164
Domaini648 – 829AMOPPROSITE-ProRule annotationAdd BLAST182

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4291, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000110943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004798_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21874

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMPITWY

Database of Orthologous Groups

More...
OrthoDBi
668024at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005533, AMOP_dom
IPR003886, NIDO_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03782, AMOP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00723, AMOP, 1 hit
SM00539, NIDO, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50856, AMOP, 1 hit
PS51220, NIDO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q21874-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRGCRHHLA AVVLLIATFP PLAYNQNIGG INQNIGGTPQ NPTINQVSPG
60 70 80 90 100
QIFSGTGNNP FYGVNLVPFG PEAGDLMVNP SMLTSGMTID LYMFFPYYGG
110 120 130 140 150
LYNYTTISVN GYLGFATVLD QGPTINVGPE TTDWPRQEDP AMIAPYLCKQ
160 170 180 190 200
QVPQQGNPAR RAGVYYRLLL RQSLFGRESN SNLNLGGTLQ QNAFFGQQAS
210 220 230 240 250
QACPGTADSY VRCDSNSDYF LDQMMIWVQE GVAGGAMFRA DAAVVVTWYN
260 270 280 290 300
TASAISGRSD IDAGQTGTYQ VIWLTDSTAR LSYVIINYDR LGFDAQDFRG
310 320 330 340 350
NSRSGRCRAV FNGGNHTGTV EVDPTQPYKN TPKVLAQRSG VPHMVRGRYM
360 370 380 390 400
FRVDDVVRPA GCSNKTGGTY PIMIYPNIVN MLGDMTVDVN ACCLDRTQTY
410 420 430 440 450
IMMIEEREVA TCQVINPAIA RCSLPRIYDW GTKTVYFQPE SRGANDEKAF
460 470 480 490 500
VGYIYFVPPT LDPMRLDIGN IYEWYKNPMT NYLMPITWYP RNFTNPDILT
510 520 530 540 550
NGNNMGVRIS DDSMYGVQLG LYIVGYREFK DDEIKKFRPE YRTLARITTY
560 570 580 590 600
SNQNNANYRW MPQEEVINTN QVQQWYLTDW ERMHTLYTYR VGFFKLAPIN
610 620 630 640 650
PNDANGTQLL PGLVSAPISL HWLWTPENQQ FATLTLNQQD RDQRIEFVKE
660 670 680 690 700
KSREMCHDWY DEDGALWNFI RDTETNTSCP CIETQALLDL GRFMPHPRCS
710 720 730 740 750
QMFRDITCTT VIGSKNCYMS SSNIYSSYAG NGNTFNNMDT NRFMTHYGQV
760 770 780 790 800
CCYDESGYLM QTPYQPVIKT QREYFYNPGY PLRAYEFGTA PYMGQFEVPG
810 820 830 840 850
LSVFHNDYMP YFLCCKFADF RCQMFYWRRP SSACQQYQPP AIGHAQGAGV
860 870 880 890 900
FQTIDNDKFI FNQPGVFNFL YIPQSVRTPE VRIQTRLERY PNRKVDFGLL
910 920 930 940 950
GRYISQYELV QPTNATVITG IALEATGTER VIVMTRKDTR RFRYRTNIIV
960 970 980 990 1000
GNILRYFDTI RLQRFRGVLI YVNNVERGQP EIYVVLEEAQ IGVKVTESYA
1010 1020 1030 1040 1050
LDIDRLPNYQ ESMGMLDIQI SVSPQYGVRP DGDKTQETQY RQMYNLPRVS
1060 1070 1080 1090 1100
GLIRPYPDQT SGSLNEGLTL NDVNSDSYRQ QIINNYLVLG TGEPGTQQNQ
1110 1120 1130 1140 1150
AGTLNQNMPQ DNMFTTSRDE DKQFDVFPEA SMRSEPVYKT APIFDTGSYR
1160 1170 1180 1190 1200
FVPQTGAMIL QLLNTCRDLQ NNPNTDLQPY QSIATLSYGL QCPDDPGQVL
1210 1220 1230 1240 1250
TECGDSVACL YDYALLNSKV LGQEEQDAWN MFTTDRALAI RQYNSCGAIN
1260 1270 1280 1290 1300
IEYPEYMMKT PALSSGYLQG DVARFECYQS HWVKGDHEYK CGIVVDYNRP
1310 1320 1330 1340 1350
NEYRFEWNKG NQPWCRSRIK ENYFKWLAVI AGIVGIIIVI LLIFLVFWCI
1360 1370 1380 1390 1400
KRKKLQESRN YSGTAAYSNN AFQNQTYETK PSRALSVGDL STAPRTVAMP
1410 1420 1430
PPRGTTATPM TLEPRGFSPV PSDVRGSQGM LGLNTSV
Length:1,437
Mass (Da):163,398
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF37B933A9D82CFEC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z70287 Genomic DNA Translation: CAA94300.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T24088

NCBI Reference Sequences

More...
RefSeqi
NP_501890.2, NM_069489.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R09E10.5.1; R09E10.5.1; WBGene00011175

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
187743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_R09E10.5

UCSC genome browser

More...
UCSCi
R09E10.5, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70287 Genomic DNA Translation: CAA94300.2
PIRiT24088
RefSeqiNP_501890.2, NM_069489.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.R09E10.5

PTM databases

iPTMnetiQ21874

Proteomic databases

EPDiQ21874
PaxDbiQ21874
PeptideAtlasiQ21874

Genome annotation databases

EnsemblMetazoaiR09E10.5.1; R09E10.5.1; WBGene00011175
GeneIDi187743
KEGGicel:CELE_R09E10.5
UCSCiR09E10.5, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
187743
WormBaseiR09E10.5 ; CE48460 ; WBGene00011175

Phylogenomic databases

eggNOGiKOG4291, Eukaryota
GeneTreeiENSGT00730000110943
HOGENOMiCLU_004798_0_0_1
InParanoidiQ21874
OMAiLMPITWY
OrthoDBi668024at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21874

Gene expression databases

BgeeiWBGene00011175, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR005533, AMOP_dom
IPR003886, NIDO_dom
PfamiView protein in Pfam
PF03782, AMOP, 1 hit
SMARTiView protein in SMART
SM00723, AMOP, 1 hit
SM00539, NIDO, 1 hit
PROSITEiView protein in PROSITE
PS50856, AMOP, 1 hit
PS51220, NIDO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYF1M_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21874
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 16, 2014
Last modified: October 7, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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