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Entry version 154 (16 Jan 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Mitotic checkpoint serine/threonine-protein kinase bub-1

Gene

bub-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase essential for spindle-assembly checkpoint signaling. Plays a key role in the recruitment of the checkpoint proteins bub-3, mdf-1 and mdf-2 to unattached kinetochores (PubMed:18936247, PubMed:19109417, PubMed:24567362, PubMed:25987605). mdf-1 recruitment is independent of bub-1 kinase activity (PubMed:24567362). Has a role in the correct kinetochore localization of the spindly-like protein spdl-1 (PubMed:18765790). In addition, during meiotic anaphase I, controls the recruitment of hcp-1/2 and klp-19 to the ring-shaped domain formed between chromosomes (PubMed:20729837). Involved in chromosome alignment, chromosome homolog segregation and spindle assembly (PubMed:20729837, PubMed:25987605). In association with bub-3 at the kinetochore region of chromosomes, promotes the onset on anaphase independently from spindle checkpoint signaling and promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605). Plays a role in nuclear envelope breakdown (PubMed:19109417). Required maternally during embryogenesis and in the zygote for the postembryonic development of several tissues including ventral cord neurons, gonad, intestine and seam cells (PubMed:19526056).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei718ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei814Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi696 – 704ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-141430 Inactivation of APC/C via direct inhibition of the APC/C complex

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q21776

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitotic checkpoint serine/threonine-protein kinase bub-1By similarity (EC:2.7.11.11 Publication)
Alternative name(s):
Budding uninhibited by benzimidazole 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bub-1Imported
ORF Names:R06C7.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
R06C7.8 ; CE06251 ; WBGene00000275 ; bub-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal (PubMed:25987605). RNAi-mediated knockdown in oocytes results in aberrant homologous chromosome segregation during meiosis due to severe pre-anaphase spindle defects characterized by disorganized microtubule bundles (PubMed:20729837). Delays in the processes leading up to exit from mitosis including delayed activation of separase, which results in a delay in the separation of sister chromatids, delayed cytokinesis onset and delayed chromosome decondensation (PubMed:25987605). These culminate in a delay in the onset of anaphase with a 50% increase in the interval between nuclear envelope breakdown and the onset of anaphase during embryogenesis (PubMed:25987605). Reduced bub-3 localization at the kinetochore region of chromosomes in embryos, but without a reduction in bub-3 protein (PubMed:25987605). In addition there is reduced localization of the spindly-like protein spdl-1 to kinetochores (PubMed:18765790).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi718K → R: No effect on embryo viability, severe loss of mdf-1 recruitment to unattached kinetochores and probably loss of kinase activity; when associated with N-847. 1 Publication1
Mutagenesisi777L → K: Loss of interaction with mdf-1 but not with bub-3. No effect on embryo viability and severe loss of mdf-1 recruitment to unattached kinetochores; when associated with K-781. 1 Publication1
Mutagenesisi781N → K: Loss of interaction with mdf-1 but not with bub-3. No effect on embryo viability and severe loss of mdf-1 recruitment to unattached kinetochores; when associated with K-777. 1 Publication1
Mutagenesisi814D → N: Loss of activity. No effect on embryo viability and mdf-1 recruitment to unattached kinetochores. 1 Publication1
Mutagenesisi847D → N: No effect on embryo viability, severe loss of mdf-1 recruitment to unattached kinetochores and probably loss of kinase activity; when associated with N-718. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004330161 – 987Mitotic checkpoint serine/threonine-protein kinase bub-1Add BLAST987

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21776

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21776

PeptideAtlas

More...
PeptideAtlasi
Q21776

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryogenesis mainly in dividing cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000275 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via kinase domain) with mdf-1 (via coiled coil domain); the interaction recruits mdf-1 to unattached kinetochores during mitosis and between homologous chromosomes in early anaphase of meiosis I (PubMed:24567362). May interact with bub-3; for localization at the kinetochore and the onset of anaphase (PubMed:24567362, PubMed:25987605).1 Publication2 Publications

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-400 Bub-1-Bub-3 complex
CPX-401 Mitotic checkpoint complex, Mad-1-Mad-2-Bub-1-Bub-3 subcomplex

Database of interacting proteins

More...
DIPi
DIP-27465N

Protein interaction database and analysis system

More...
IntActi
Q21776, 4 interactors

STRING: functional protein association networks

More...
STRINGi
6239.R06C7.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q21776

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21776

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini690 – 987Protein kinasePROSITE-ProRule annotationAdd BLAST298

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1166 Eukaryota
ENOG410XQ67 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019104

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21776

KEGG Orthology (KO)

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KOi
K02178

Identification of Orthologs from Complete Genome Data

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OMAi
ADWCIMQ

Database of Orthologous Groups

More...
OrthoDBi
441269at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015661 Bub1/Mad3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR14030 PTHR14030, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q21776-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHIRVAFAP LDTNPSTCGL ETFATQIETL SQMMTAEEMK AELYDCVRRI
60 70 80 90 100
LREQKFDQIR ENEAMLRLYK VMGRSSTNLK GRGIYEQLFK KDHFTGSLKF
110 120 130 140 150
YLQWAEECGK DQMLEEFKDV LKLARDRLSE RIEMTAIESG FRDLVDEYFN
160 170 180 190 200
GESGDMFTRP DETMDLFRFN AGSKKKRRSS VCFLQHNVPI NNSGKAAFGP
210 220 230 240 250
KTKTDLRQAC IDRPNYHGIS IEEFRFAKWK DTFGEDVDDD YRKRKDSGVV
260 270 280 290 300
FVKHQVIDTD RQAREEVENR FNANLNPRRR HLSPVSEKTV DDEEEKRSRI
310 320 330 340 350
YSPLVATKDA HRPALRSKIE NPPATVTLSS DTKSASEKDV SDSDDADDDE
360 370 380 390 400
RLKIMTAGRK DGNPPDRSTS ISSNYSTASA RTSKSGAGLD LMAENKCLEA
410 420 430 440 450
HAMFSDTVHL ASEKTMVLGD DSVFVPERSL ATTQIVTDFS VLCDPDPTMT
460 470 480 490 500
ITQERPKKVS NGLNVVYDEA AEPEESQKVE ESEVQPEIVL VSPVTQTSPA
510 520 530 540 550
TMFNDIYDDE IEFGFFKPSR GNFVTSTPAQ GVHLVNIDEY FGNKEEESTH
560 570 580 590 600
EQEAPVFVAP TSSTFSKLTR RKSLAANQAV QPSVTESSKP ERSDPKDSSI
610 620 630 640 650
DCLTANLGRR LSIGADEIPN LTENNESEIT GCKIRRRSEI IKQGDINPWD
660 670 680 690 700
ETLRKKLMCL VRPPQNMHEF QERAPKIQAL RDCEVSGEKL HIQTLIGQGG
710 720 730 740 750
YAKVYRAVTD DQRTVAVKYE VPSCSWEVYI CDQMRNRLKD RGLELMAKCC
760 770 780 790 800
IMEVMDAYVY STASLLVNQY HEYGTLLEYA NNMKDPNWHI TCFLITQMAR
810 820 830 840 850
VVKEVHASKI IHGDIKPDNF MITRKIDDKW GKDALMSNDS FVIKIIDWGR
860 870 880 890 900
AIDMMPLKNQ RFKGRAGTEA FDCPEMVDGR SWTYQADYFG FAATMAVVVA
910 920 930 940 950
GKYAQLTGAS VGDYSLNVDI KRRNILRDAC YDVINRFLNI PSCDSLPDWN
960 970 980
ILIKSFSEIW NEKFEASGWR QAVSKFNEAC DLAANQK
Length:987
Mass (Da):112,034
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48E7915551AE2194
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA95845.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T23971

NCBI Reference Sequences

More...
RefSeqi
NP_492051.1, NM_059650.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.17390

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R06C7.8; R06C7.8; WBGene00000275

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172468

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_R06C7.8

UCSC genome browser

More...
UCSCi
R06C7.8 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA95845.1
PIRiT23971
RefSeqiNP_492051.1, NM_059650.4
UniGeneiCel.17390

3D structure databases

ProteinModelPortaliQ21776
SMRiQ21776
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-400 Bub-1-Bub-3 complex
CPX-401 Mitotic checkpoint complex, Mad-1-Mad-2-Bub-1-Bub-3 subcomplex
DIPiDIP-27465N
IntActiQ21776, 4 interactors
STRINGi6239.R06C7.8

Proteomic databases

EPDiQ21776
PaxDbiQ21776
PeptideAtlasiQ21776

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR06C7.8; R06C7.8; WBGene00000275
GeneIDi172468
KEGGicel:CELE_R06C7.8
UCSCiR06C7.8 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172468
WormBaseiR06C7.8 ; CE06251 ; WBGene00000275 ; bub-1

Phylogenomic databases

eggNOGiKOG1166 Eukaryota
ENOG410XQ67 LUCA
GeneTreeiENSGT00940000167713
HOGENOMiHOG000019104
InParanoidiQ21776
KOiK02178
OMAiADWCIMQ
OrthoDBi441269at2759

Enzyme and pathway databases

ReactomeiR-CEL-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
SignaLinkiQ21776

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21776

Gene expression databases

BgeeiWBGene00000275 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR015661 Bub1/Mad3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR14030 PTHR14030, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBUB1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21776
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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