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Entry version 142 (07 Apr 2021)
Sequence version 3 (01 Mar 2003)
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Protein
Submitted name:

P-type domain-containing protein

Gene

aagr-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-189085, Digestion of dietary carbohydrate
R-CEL-6798695, Neutrophil degranulation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH31, Glycoside Hydrolase Family 31

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
P-type domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aagr-2Imported
ORF Names:CELE_R05F9.12Imported, R05F9.12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
R05F9.12 ; CE31976 ; WBGene00019895 ; aagr-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500420011819 – 955Sequence analysisAdd BLAST937

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21750

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21750

PeptideAtlas

More...
PeptideAtlasi
Q21750

2D gel databases

The World-2DPAGE database

More...
World-2DPAGEi
0011:Q21750
0020:Q21750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00019895, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.R05F9.12

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21750

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 58P-typeInterPro annotationAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1065, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170776

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000631_11_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21750

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLMTPYW

Database of Orthologous Groups

More...
OrthoDBi
151244at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q21750

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00111, Trefoil, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031727, Gal_mutarotase_N
IPR011013, Gal_mutarotase_sf_dom
IPR000322, Glyco_hydro_31
IPR030458, Glyco_hydro_31_AS
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR000519, P_trefoil_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01055, Glyco_hydro_31, 1 hit
PF16863, NtCtMGAM_N, 1 hit
PF00088, Trefoil, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00018, PD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445, SSF51445, 1 hit
SSF74650, SSF74650, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00129, GLYCOSYL_HYDROL_F31_1, 1 hit
PS51448, P_TREFOIL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q21750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKVTLLLLF VLLAFANAAP RFDCLPEPNG NQGACEARGC IWKEDDTGKN
60 70 80 90 100
APWCYFKDGV GYNLDSQQGS TYNLRKNGGP SNPWGADSTE IKLTTKSIGS
110 120 130 140 150
VLNVKIGIDG RYEPPVDFPR ETQSSTESLS LSTSFSNGVF SFSVVRQSTN
160 170 180 190 200
RKLFDTSIGG LIFSDQFIQI ATYLPSENMY GWGENTHQSL RHDFTKYLTW
210 220 230 240 250
AMFARDQPPN SGSLDTVNLY GVHPYYMILE PDGKAHGVLI INSNAQEVTT
260 270 280 290 300
APGPSLIYRT IGGNLDMYFF PGPTPEMVTQ QYLKFIGKPF LPAYWALGYQ
310 320 330 340 350
LSRYGYKGLA EMKTRIQAVR DAGIPIDIGV ADIDYMQRYK DFTTGDDWAG
360 370 380 390 400
FSDYVKTMHD WGMKLILIFD PAIEATYPSF QRAIAANAKF IEWETKAQVQ
410 420 430 440 450
TAIQNLYPMA KDTKIMLGVV WPDNHVAFPD FLDSTNNTQN WWINEFVNYQ
460 470 480 490 500
SQVAFDGIWI DMNEPSNFGT NQDHPWYFDS DDHPNDAPLF CPTNGSSPWE
510 520 530 540 550
MPPYKTRAVW RFGDANSGAF LSSNTLCMLA QQDGGKQRFY NVKNLYGLTE
560 570 580 590 600
AINTQKALFK ATGKRGAVVS RSTYPSAGRY AGHWLGDNTA RWEDLRTSVI
610 620 630 640 650
GAQEFNLFGI PYVGSDVCGF IGTTTEELCL RWQQMGAFHS FFRNHNTIGA
660 670 680 690 700
PAQDPAVWPS VAAATKKANL FRYQYLPYLF SLHFTASLSG ATVIRPVFFE
710 720 730 740 750
YPTDAETFNL GYEFMWGSRI LVAPVIYQGT TSVNAYLPTD RWYSLFDYRY
760 770 780 790 800
GSIMSPGYAT VPAPTTSRIP VFVRGYSVIP RQTPSITTTA TRSNPFELLI
810 820 830 840 850
APCPLGMGEG TLYWDDGETI VNDFNSYDYH QFDFMYNSTA TGGSVTITHS
860 870 880 890 900
KKSSKISLPT LDIIEIFNYP SAPNFRSFTI NGKLVNVNVQ RSTYSGITKI
910 920 930 940 950
LYISTEGLVN LSSADSIVLQ WSNAGNSMFD ISSASSDEVG KMKALNTNRY

DELYF
Length:955
Mass (Da):106,841
Last modified:March 1, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF3D4593BF82AD45
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD69278.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16693

NCBI Reference Sequences

More...
RefSeqi
NP_494897.3, NM_062496.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R05F9.12.1; R05F9.12.1; WBGene00019895

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_R05F9.12

UCSC genome browser

More...
UCSCi
R05F9.12, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD69278.1
PIRiT16693
RefSeqiNP_494897.3, NM_062496.6

3D structure databases

SMRiQ21750
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.R05F9.12

Protein family/group databases

CAZyiGH31, Glycoside Hydrolase Family 31

2D gel databases

World-2DPAGEi0011:Q21750
0020:Q21750

Proteomic databases

EPDiQ21750
PaxDbiQ21750
PeptideAtlasiQ21750

Genome annotation databases

EnsemblMetazoaiR05F9.12.1; R05F9.12.1; WBGene00019895
GeneIDi173848
KEGGicel:CELE_R05F9.12
UCSCiR05F9.12, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173848
WormBaseiR05F9.12 ; CE31976 ; WBGene00019895 ; aagr-2

Phylogenomic databases

eggNOGiKOG1065, Eukaryota
GeneTreeiENSGT00940000170776
HOGENOMiCLU_000631_11_2_1
InParanoidiQ21750
OMAiPLMTPYW
OrthoDBi151244at2759
PhylomeDBiQ21750

Enzyme and pathway databases

ReactomeiR-CEL-189085, Digestion of dietary carbohydrate
R-CEL-6798695, Neutrophil degranulation

Gene expression databases

BgeeiWBGene00019895, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

CDDicd00111, Trefoil, 1 hit
Gene3Di2.60.40.1180, 2 hits
InterProiView protein in InterPro
IPR031727, Gal_mutarotase_N
IPR011013, Gal_mutarotase_sf_dom
IPR000322, Glyco_hydro_31
IPR030458, Glyco_hydro_31_AS
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR000519, P_trefoil_dom
PfamiView protein in Pfam
PF01055, Glyco_hydro_31, 1 hit
PF16863, NtCtMGAM_N, 1 hit
PF00088, Trefoil, 1 hit
SMARTiView protein in SMART
SM00018, PD, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit
SSF74650, SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00129, GLYCOSYL_HYDROL_F31_1, 1 hit
PS51448, P_TREFOIL_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ21750_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21750
Secondary accession number(s): Q23517
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: March 1, 2003
Last modified: April 7, 2021
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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