Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 118 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Nuclear RNAi defective-3 protein

Gene

nrde-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei (PubMed:18653886). Required for exogenous RNAi-induced H3K27 methylation (PubMed:26365259).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-203927, MicroRNA (miRNA) biogenesis
R-CEL-426486, Small interfering RNA (siRNA) biogenesis
R-CEL-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNAi defective-3 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nrde-3
ORF Names:R04A9.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
R04A9.2 ; CE04789 ; WBGene00019862 ; nrde-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi80K → A: No nuclear localization. 1 Publication1
Mutagenesisi81R → A: No nuclear localization. 1 Publication1
Mutagenesisi82K → A: No nuclear localization. 1 Publication1
Mutagenesisi463Y → A: Fails to interact with siRNAs and localizes predominantly to the cytoplasm. 1 Publication1
Mutagenesisi464Y → A: Fails to interact with siRNAs and localizes predominantly to the cytoplasm. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004209731 – 1057Nuclear RNAi defective-3 proteinAdd BLAST1057

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21691

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21691

PeptideAtlas

More...
PeptideAtlasi
Q21691

PRoteomics IDEntifications database

More...
PRIDEi
Q21691

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00019862, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
45345, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-55715N

Protein interaction database and analysis system

More...
IntActi
Q21691, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.R04A9.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21691

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini385 – 500PAZPROSITE-ProRule annotationAdd BLAST116
Domaini677 – 1001PiwiPROSITE-ProRule annotationAdd BLAST325

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1041, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012806_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21691

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTRGPNA

Database of Orthologous Groups

More...
OrthoDBi
540725at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q21691

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00949, PAZ, 1 hit
SM00950, Piwi, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q21691-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLLDKVMGE MGSKPGSTAK KPATSASSTP RTNVWGTAKK PSSQQQPPKP
60 70 80 90 100
LFTTPGSQQG SLGGRIPKRE HTDRTGPDPK RKPLGGLSVP DSFNNFGTFR
110 120 130 140 150
VQMNAWNLDI SKMDERISRI MFRATLVHTD GRRFELSLGV SAFSGDVNRQ
160 170 180 190 200
QRRQAQCLLF RAWFKRNPEL FKGMTDPAIA AYDAAETIYV GCSFFDVELT
210 220 230 240 250
EHVCHLTEAD FSPQEWKIVS LISRRSGSTF EIRIKTNPPI YTRGPNALTL
260 270 280 290 300
ENRSELTRII EAITDQCLHN EKFLLYSSGT FPTKGGDIAS PDEVTLIKSG
310 320 330 340 350
FVKTTKIVDR DGVPDAIMTV DTTKSPFYKD TSLLKFFTAK MDQLTNSGGG
360 370 380 390 400
PRGHNGGRER RDGGGNSRKY DDRRSPRDGE IDYDERTVSH YQRQFQDERI
410 420 430 440 450
SDGMLNTLKQ SLKGLDCQPI HLKDSKANRS IMIDEIHTGT ADSVTFEQKL
460 470 480 490 500
PDGEMKLTSI TEYYLQRYNY RLKFPHLPLV TSKRAKCYDF YPMELMSILP
510 520 530 540 550
GQRIKQSHMT VDIQSYMTGK MSSLPDQHIK QSKLVLTEYL KLGDQPANRQ
560 570 580 590 600
MDAFRVSLKS IQPIVTNAHW LSPPDMKFAN NQLYSLNPTR GVRFQTNGKF
610 620 630 640 650
VMPARVKSVT IINYDKEFNR NVDMFAEGLA KHCSEQGMKF DSRPNSWKKV
660 670 680 690 700
NLGSSDRRGT KVEIEEAIRN GVTIVFGIIA EKRPDMHDIL KYFEEKLGQQ
710 720 730 740 750
TIQISSETAD KFMRDHGGKQ TIDNVIRKLN PKCGGTNFLI DVPESVGHRV
760 770 780 790 800
VCNNSAEMRA KLYAKTQFIG FEMSHTGART RFDIQKVMFD GDPTVVGVAY
810 820 830 840 850
SLKHSAQLGG FSYFQESRLH KLTNLQEKMQ ICLNAYEQSS SYLPETVVVY
860 870 880 890 900
RVGSGEGDYP QIVNEVNEMK LAARKKKHGY NPKFLVICTQ RNSHIRVFPE
910 920 930 940 950
HINERGKSME QNVKSGTCVD VPGASHGYEE FILCCQTPLI GTVKPTKYTI
960 970 980 990 1000
IVNDCRWSKN EIMNVTYHLA FAHQVSYAPP AIPNVSYAAQ NLAKRGHNNY
1010 1020 1030 1040 1050
KTHTKLVDMN DYSYRIKEKH EEIISSEEVD DILMRDFIET VSNDLNAMTI

NGRNFWA
Length:1,057
Mass (Da):119,713
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC86F4A37DE64F519
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080331 Genomic DNA Translation: CCD62910.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16676

NCBI Reference Sequences

More...
RefSeqi
NP_508092.1, NM_075691.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R04A9.2.1; R04A9.2.1; WBGene00019862

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_R04A9.2

UCSC genome browser

More...
UCSCi
R04A9.2, c. elegans

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080331 Genomic DNA Translation: CCD62910.1
PIRiT16676
RefSeqiNP_508092.1, NM_075691.4

3D structure databases

SMRiQ21691
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi45345, 2 interactors
DIPiDIP-55715N
IntActiQ21691, 2 interactors
STRINGi6239.R04A9.2

Proteomic databases

EPDiQ21691
PaxDbiQ21691
PeptideAtlasiQ21691
PRIDEiQ21691

Genome annotation databases

EnsemblMetazoaiR04A9.2.1; R04A9.2.1; WBGene00019862
GeneIDi180392
KEGGicel:CELE_R04A9.2
UCSCiR04A9.2, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180392
WormBaseiR04A9.2 ; CE04789 ; WBGene00019862 ; nrde-3

Phylogenomic databases

eggNOGiKOG1041, Eukaryota
HOGENOMiCLU_012806_0_0_1
InParanoidiQ21691
OMAiYTRGPNA
OrthoDBi540725at2759
PhylomeDBiQ21691

Enzyme and pathway databases

ReactomeiR-CEL-203927, MicroRNA (miRNA) biogenesis
R-CEL-426486, Small interfering RNA (siRNA) biogenesis
R-CEL-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21691

Gene expression databases

BgeeiWBGene00019862, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit
SMARTiView protein in SMART
SM00949, PAZ, 1 hit
SM00950, Piwi, 1 hit
SUPFAMiSSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRDE3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21691
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again