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Entry version 124 (12 Aug 2020)
Sequence version 3 (22 Sep 2009)
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Protein

Putative patatin-like phospholipase domain-containing protein M110.7

Gene

M110.7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei801NucleophilePROSITE-ProRule annotation1
Active sitei922Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi144 – 237cNMP 1PROSITE-ProRule annotationAdd BLAST94
Nucleotide bindingi327 – 416cNMP 2PROSITE-ProRule annotationAdd BLAST90
Nucleotide bindingi450 – 509cNMP 3PROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lysophospholipase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-6814848, Glycerophospholipid catabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative patatin-like phospholipase domain-containing protein M110.7Curated (EC:3.1.1.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:M110.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
M110.7 ; CE43244 ; WBGene00010915

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001725301 – 1095Putative patatin-like phospholipase domain-containing protein M110.7Add BLAST1095

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21534

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21534

PRoteomics IDEntifications database

More...
PRIDEi
Q21534

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00010915, Expressed in adult organism and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.M110.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21534

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini768 – 935PNPLAPROSITE-ProRule annotationAdd BLAST168

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi772 – 777GXGXXGPROSITE-ProRule annotation6
Motifi799 – 803GXSXGPROSITE-ProRule annotation5
Motifi922 – 924DGA/GPROSITE-ProRule annotation3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2968, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000960_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21534

Identification of Orthologs from Complete Genome Data

More...
OMAi
WIRTIQV

Database of Orthologous Groups

More...
OrthoDBi
253518at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q21534

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038, CAP_ED, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR001423, LysoPLipase_patatin_CS
IPR002641, PNPLA_dom
IPR014710, RmlC-like_jellyroll

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00027, cNMP_binding, 1 hit
PF01734, Patatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100, cNMP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51206, SSF51206, 3 hits
SSF52151, SSF52151, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS51635, PNPLA, 1 hit
PS01237, UPF0028, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q21534-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHYLLSVLL LIFENILELC MCITLVILIY YFWPSKQLED ATLQYFPDTT
60 70 80 90 100
QNSSEVFIDP PERNPIFYPI SPLRHKKRSS KEEMTPDKKR DSSEKISKQP
110 120 130 140 150
PRELFEPNEQ EQVPSHIKPE IFFVLKALEG LELPTTWQLD PKDVETLSID
160 170 180 190 200
TGSVVLSPGR ANDVIVVVIS GELGIFTNVS LGDKRYDCNI KTLRSGESYF
210 220 230 240 250
SQTSIIEILM NEKPNNKYIH LKALTSCRVA TYHLTSFHTS FIANPQQWIR
260 270 280 290 300
TIQVVMTRLQ QCTLITCNMY LGIGGKCLNA KRKLPDSGKF KDFNKLTEAE
310 320 330 340 350
QLNKGVEAIA QAMGIPDQSD KLREKVRKYE CQAGTVVTEE NSFEIDMIFV
360 370 380 390 400
VFGKLRLKRG DLEHDDTGTS LTFDVYPGDM LPSMQILTNE PAMCSAKALE
410 420 430 440 450
KTIYFKICRD EYIQFLFAHP VIYLRLAFHA LQFISPFARV FDMAVHWHRI
460 470 480 490 500
ETGQALFRQG DKSDSMHIVM GGRLRAVDST KIIEEYGRLD LIGITDMAEK
510 520 530 540 550
RPRRNTVMAV RFSHIVCIPE NLLSFVKIRY PQVGNKLLKL ISKCWKAPTP
560 570 580 590 600
ETMSHVETTR NQNLRTIAIV PASRRVPLTE FTCELYNQLS KHVKTLRLSS
610 620 630 640 650
SVVENYFESE VITKKADYGL MHWLNVQEIA YSLVLYQCDF HKTNWTRRCL
660 670 680 690 700
RMADAILMVA LGTESKEEQV LAEALLSCNE KGVRQSKELV FLWPIDTPTP
710 720 730 740 750
SGTAAWIKES YYSGYHHLRA PNRLFSFPLK TREKKIVEYY ETTVYGEISY
760 770 780 790 800
QSDFSRLARI LTGNAIGIVF GGGGARGAAH AGALRALIEK KVQIDMVGGT
810 820 830 840 850
SIGALFGSLY ATTPDIRAVG RMKDFFTDRL RNNILDVVRD LTWPYCGILT
860 870 880 890 900
GHRFNLCVQR MLNDVNIEDC WVSFFCITTD LTSSSMRIHR NGIMWPVVRS
910 920 930 940 950
SMSIAGYVPP ICDPQDGHLL LDGAYVNNLP ADIMRSLGAN VVIAIDVGMS
960 970 980 990 1000
DDNTNLRNYG FSISGTWCLF KRWWPFGEEL RVLNMNEVQN RLAYVCCVNQ
1010 1020 1030 1040 1050
MEIVKNAQYC YYVKLPIESF GIFDFSKFDQ AAQIGYDITK QKMEEFFEDS
1060 1070 1080 1090
VATRRKLLGC ARNVRQTPQK SKNDNILSFV NMPVLPKPPS DIKSD
Length:1,095
Mass (Da):124,856
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA52D68E2BC62CB98
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602, Z49966 Genomic DNA Translation: CAA90264.3

Protein sequence database of the Protein Information Resource

More...
PIRi
T21745

NCBI Reference Sequences

More...
RefSeqi
NP_495734.3, NM_063333.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
M110.7.1; M110.7.1; WBGene00010915

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
187474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_M110.7

UCSC genome browser

More...
UCSCi
M110.7, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602, Z49966 Genomic DNA Translation: CAA90264.3
PIRiT21745
RefSeqiNP_495734.3, NM_063333.3

3D structure databases

SMRiQ21534
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.M110.7

Proteomic databases

EPDiQ21534
PaxDbiQ21534
PRIDEiQ21534

Genome annotation databases

EnsemblMetazoaiM110.7.1; M110.7.1; WBGene00010915
GeneIDi187474
KEGGicel:CELE_M110.7
UCSCiM110.7, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
187474
WormBaseiM110.7 ; CE43244 ; WBGene00010915

Phylogenomic databases

eggNOGiKOG2968, Eukaryota
HOGENOMiCLU_000960_1_0_1
InParanoidiQ21534
OMAiWIRTIQV
OrthoDBi253518at2759
PhylomeDBiQ21534

Enzyme and pathway databases

ReactomeiR-CEL-6814848, Glycerophospholipid catabolism

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21534

Gene expression databases

BgeeiWBGene00010915, Expressed in adult organism and 3 other tissues

Family and domain databases

CDDicd00038, CAP_ED, 2 hits
Gene3Di2.60.120.10, 3 hits
InterProiView protein in InterPro
IPR016035, Acyl_Trfase/lysoPLipase
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR001423, LysoPLipase_patatin_CS
IPR002641, PNPLA_dom
IPR014710, RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027, cNMP_binding, 1 hit
PF01734, Patatin, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 3 hits
SUPFAMiSSF51206, SSF51206, 3 hits
SSF52151, SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS51635, PNPLA, 1 hit
PS01237, UPF0028, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPL6_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21534
Secondary accession number(s): Q20023
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: August 12, 2020
This is version 124 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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