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UniProtKB - Q21528 (Q21528_CAEEL)
Protein
Submitted name:
Col_cuticle_N domain-containing protein
Gene
col-76
Organism
Caenorhabditis elegans
Status
Functioni
GO - Molecular functioni
- extracellular matrix structural constituent Source: GO_Central
- structural constituent of cuticle Source: InterPro
GO - Biological processi
- anatomical structure development Source: UniProt
- extracellular matrix organization Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Col_cuticle_N domain-containing proteinImported |
Gene namesi | Name:col-76Imported ORF Names:CELE_M110.1Imported, M110.1Imported |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | M110.1 ; CE35898 ; WBGene00000652 ; col-76 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- extracellular matrix Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 33 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
EPDi | Q21528 |
PaxDbi | Q21528 |
Expressioni
Gene expression databases
Bgeei | WBGene00000652, Expressed in multi-cellular organism and 4 other tissues |
Interactioni
Subunit structurei
Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
ARBA annotationProtein-protein interaction databases
STRINGi | 6239.M110.1 |
Structurei
3D structure databases
AlphaFoldDBi | Q21528 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 61 | Col_cuticle_NInterPro annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 83 – 353 | DisorderedSequence analysisAdd BLAST | 271 | |
Regioni | 473 – 499 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 292 – 321 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 338 – 353 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the cuticular collagen family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00970000196141 |
HOGENOMi | CLU_532346_0_0_1 |
InParanoidi | Q21528 |
OMAi | NGIPGRM |
OrthoDBi | 1176806at2759 |
PhylomeDBi | Q21528 |
Family and domain databases
InterProi | View protein in InterPro IPR002486, Col_cuticle_N IPR008160, Collagen |
Pfami | View protein in Pfam PF01484, Col_cuticle_N, 1 hit PF01391, Collagen, 1 hit |
SMARTi | View protein in SMART SM01088, Col_cuticle_N, 1 hit |
i Sequence
Sequence statusi: Complete.
Q21528-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVPHSPQSI LVVSTVISTF TFLATITLLP LFYMKVQRIN SQMLTDLRNC
60 70 80 90 100
HQDSTDIWKQ LSQENVRGKR SYGRDAPSIP MGKCCSCQQG KPGPTGPKGP
110 120 130 140 150
DGGPGQPGLI GLNGRNGRNG KYVASEAHNE PACQKCPVAP PGPPGHPGRK
160 170 180 190 200
GPRGTAGNAG TAGKNGIPGR MGPPGPAGVR GPPGELGMRG PQGDPGKVLN
210 220 230 240 250
GAPQGQPGRP GKVGSRGKAG HTGRDGRPGL EGTPGTRGVQ GERGSRGARG
260 270 280 290 300
PPGPPGPAGS DGRKGSCAHC QSDDKLSQGG ANRRPEETDP EGEFSNQQPA
310 320 330 340 350
SYEEQPPVIT TTTTETAPVY TNPPAHQPVH RSFPSAEPRQ SHKNSPSVPV
360 370 380 390 400
PQEQYNSANS EVIPKTINYP DTINHQSYKH DGDVSVAGTT DDSEDVNVIP
410 420 430 440 450
AGQYSSRQYA SKTNKIGKAV HFGYSNDQLS SFVPMGATSE EDENYGKPRA
460 470 480 490
FQTNKGYNVQ IMGSGPTYNA APVGNAWKQP ENHKVRQYTP QYLPPPAYA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284602 Genomic DNA Translation: CAA90258.2 |
PIRi | T23745 |
RefSeqi | NP_495726.2, NM_063325.4 |
Genome annotation databases
EnsemblMetazoai | M110.1.1; M110.1.1; WBGene00000652 |
GeneIDi | 174320 |
KEGGi | cel:CELE_M110.1 |
UCSCi | M110.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284602 Genomic DNA Translation: CAA90258.2 |
PIRi | T23745 |
RefSeqi | NP_495726.2, NM_063325.4 |
3D structure databases
AlphaFoldDBi | Q21528 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 6239.M110.1 |
Proteomic databases
EPDi | Q21528 |
PaxDbi | Q21528 |
Genome annotation databases
EnsemblMetazoai | M110.1.1; M110.1.1; WBGene00000652 |
GeneIDi | 174320 |
KEGGi | cel:CELE_M110.1 |
UCSCi | M110.1, c. elegans |
Organism-specific databases
CTDi | 174320 |
WormBasei | M110.1 ; CE35898 ; WBGene00000652 ; col-76 |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00970000196141 |
HOGENOMi | CLU_532346_0_0_1 |
InParanoidi | Q21528 |
OMAi | NGIPGRM |
OrthoDBi | 1176806at2759 |
PhylomeDBi | Q21528 |
Gene expression databases
Bgeei | WBGene00000652, Expressed in multi-cellular organism and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002486, Col_cuticle_N IPR008160, Collagen |
Pfami | View protein in Pfam PF01484, Col_cuticle_N, 1 hit PF01391, Collagen, 1 hit |
SMARTi | View protein in SMART SM01088, Col_cuticle_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q21528_CAEEL | |
Accessioni | Q21528Primary (citable) accession number: Q21528 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |