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Entry version 126 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein lin-14

Gene

lin-14

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin-like growth factor gene ins-33. Plays a role in governing the developmental timining of male tail tip morphogenesis (PubMed:26811380, PubMed:30956008). Plays a role in controlling the timing of seam cell development during the larval stages (PubMed:21471153).7 Publications
May specify L2 and later cell fates, creating a temporal switch.1 Publication
May be involved in specifying L1 cell fates.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lin-14
Alternative name(s):
Abnormal cell lineage protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lin-14Imported
ORF Names:T25C12.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T25C12.1a ; CE43285 ; WBGene00003003 ; lin-14
T25C12.1b ; CE03734 ; WBGene00003003 ; lin-14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Asynchrony between gonadal and vulval development. Retarded uterine uv1 cell differentiation (PubMed:19161245). RNAi-mediated knockdown results in the precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:26811380, PubMed:30956008). RNAi-mediated knockdown in a ced-3 and ain-1 double mutant background reduces the percentage of animals with developmental defects including impaired egg-laying and production of ectopic seam cells (PubMed:25432023).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi303R → G in n179; precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype). Premature alae formation at the L3 larval stage. Premature alae formation is partially suppressed in a sea-2 bp283 mutant background. 2 Publications1
Mutagenesisi322A → T in n838; decrease in protein levels. 1 Publication1
Mutagenesisi381G → D in sa485; alteration of vulval-gonadal synchrony. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844251 – 539Protein lin-14Add BLAST539

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by caspase ced-3 in vitro.1 Publication

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21446

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21446

PeptideAtlas

More...
PeptideAtlasi
Q21446

PRoteomics IDEntifications database

More...
PRIDEi
Q21446

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q21446

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in hypodermal, intestinal, body wall muscle, nerve ring, and ventral nerve cord cells of embryos and L1 animals.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present at high levels in embryos and L1 animals but is undetectable at later stages.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003003, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T25C12.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q21446

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S18Y, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_520958_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q21446

Identification of Orthologs from Complete Genome Data

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OMAi
NGHIQPA

Database of Orthologous Groups

More...
OrthoDBi
796674at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q21446-1) [UniParc]FASTAAdd to basket
Also known as: B11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKGQPKEPK IEQSVVDLCK RTVAMNLLQC YPTTTVDEMN CEEWGNGTES
60 70 80 90 100
TQSVAACQGC IELRKEVTDL RQAVNLILPM LPLYPTIGNG FNATGLAAQP
110 120 130 140 150
TLQHVIQQSL LRKRPVAQTP TVPQPECPGQ IRPVLSSPAA ALQNVIMLNP
160 170 180 190 200
WIMGSSLKPA SPTLPNGQIP TTIGETSLQG TDDQTVKWIG PSSVDSNGQK
210 220 230 240 250
TDSSAASAGD NQNIDVIGDG SESPTSSNHS AQEIALMTSQ QTFLNALKDS
260 270 280 290 300
SFLFTNPVPT VETAPPLRVA PPINGTTNGT AKAGGPERKP RKPVNDDIVK
310 320 330 340 350
IVRNQDLSEE NISMFEIPVP KAIASDPTFR PVSEQQIIQQ IIQGKKYEEM
360 370 380 390 400
EVGECMIQLC KKLAEKRVFG PRLMSQTTVA GLNHSNYANL PIKGICYIQH
410 420 430 440 450
VCRKVLYDKF ENEEDFWDKF REAMRKLAAR CRRVRHAKKT KHNREEAQAE
460 470 480 490 500
MLSKRYGEDM PFNLNGAGLI RPKVETVSPE ANILNSDQIK SQLESLFAHI
510 520 530
PKTESETPLI EIIQQNISLF THLIRTKVES QSPPLQGPQ
Length:539
Mass (Da):59,343
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8939AE7F5D11E72E
GO
Isoform bImported (identifier: Q21446-2) [UniParc]FASTAAdd to basket
Also known as: A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: MGKGQPKEPK...AACQGCIELR → MDLPGTSSND...YLIRSDMSAF

Show »
Length:537
Mass (Da):59,159
Checksum:iB1403B1960131108
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 24Missing in CAA42792 (PubMed:1916264).CuratedAdd BLAST24

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0043061 – 64MGKGQ…CIELR → MDLPGTSSNDFVQPFSTFYP SPTSPPMHQAALLPALTALY PQLLQLPHLKSDYLIRSDMS AF in isoform b. CuratedAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X60231, X60232, X60233 Genomic DNA Translation: CAA42791.1
X60232, X60233 Genomic DNA Translation: CAA42792.1
X60233 Genomic DNA Translation: CAA42793.1
BX284606 Genomic DNA Translation: CAA91484.2
BX284606 Genomic DNA Translation: CAA91485.1

Protein sequence database of the Protein Information Resource

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PIRi
A40581
B89648
T25268

NCBI Reference Sequences

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RefSeqi
NP_509916.2, NM_077515.2 [Q21446-1]
NP_509917.1, NM_077516.3 [Q21446-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T25C12.1a.1; T25C12.1a.1; WBGene00003003 [Q21446-1]
T25C12.1b.1; T25C12.1b.1; WBGene00003003 [Q21446-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
181337

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T25C12.1

UCSC genome browser

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UCSCi
T25C12.1a, c. elegans [Q21446-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60231, X60232, X60233 Genomic DNA Translation: CAA42791.1
X60232, X60233 Genomic DNA Translation: CAA42792.1
X60233 Genomic DNA Translation: CAA42793.1
BX284606 Genomic DNA Translation: CAA91484.2
BX284606 Genomic DNA Translation: CAA91485.1
PIRiA40581
B89648
T25268
RefSeqiNP_509916.2, NM_077515.2 [Q21446-1]
NP_509917.1, NM_077516.3 [Q21446-2]

3D structure databases

SMRiQ21446
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.T25C12.1a

PTM databases

iPTMnetiQ21446

Proteomic databases

EPDiQ21446
PaxDbiQ21446
PeptideAtlasiQ21446
PRIDEiQ21446

Genome annotation databases

EnsemblMetazoaiT25C12.1a.1; T25C12.1a.1; WBGene00003003 [Q21446-1]
T25C12.1b.1; T25C12.1b.1; WBGene00003003 [Q21446-2]
GeneIDi181337
KEGGicel:CELE_T25C12.1
UCSCiT25C12.1a, c. elegans [Q21446-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181337
WormBaseiT25C12.1a ; CE43285 ; WBGene00003003 ; lin-14
T25C12.1b ; CE03734 ; WBGene00003003 ; lin-14

Phylogenomic databases

eggNOGiENOG502S18Y, Eukaryota
HOGENOMiCLU_520958_0_0_1
InParanoidiQ21446
OMAiNGHIQPA
OrthoDBi796674at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21446

Gene expression databases

BgeeiWBGene00003003, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIN14_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21446
Secondary accession number(s): Q21447, Q22775, Q27292
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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