Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 134 (29 Sep 2021)
Sequence version 2 (08 Apr 2008)
Previous versions | rss
Add a publicationFeedback
Protein

NRAMP-like transporter smf-1

Gene

smf-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable divalent metal ion transporter which regulates Mn2+ uptake.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1222556, ROS and RNS production in phagocytes
R-CEL-425410, Metal ion SLC transporters
R-CEL-6798695, Neutrophil degranulation
R-CEL-6803544, Ion influx/efflux at host-pathogen interface
R-CEL-917937, Iron uptake and transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.55.2.16, the metal ion (mn(2+)-iron) transporter (nramp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NRAMP-like transporter smf-1Curated
Alternative name(s):
Divalent metal transporter smf-1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:smf-1
ORF Names:K11G12.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
K11G12.4a ; CE41828 ; WBGene00004876 ; smf-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 55CytoplasmicCuratedAdd BLAST55
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 83ExtracellularCurated7
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 140CytoplasmicCuratedAdd BLAST36
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 164ExtracellularCurated3
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 194CytoplasmicCurated9
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 241ExtracellularCuratedAdd BLAST26
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 287CytoplasmicCuratedAdd BLAST25
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 347ExtracellularCuratedAdd BLAST39
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 398CytoplasmicCuratedAdd BLAST30
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 428ExtracellularCurated9
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 462CytoplasmicCuratedAdd BLAST13
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 496ExtracellularCuratedAdd BLAST13
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 562CytoplasmicCuratedAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Higher iron levels in their body compared to wild-type. Increased survival rate and reduced iron levels in their body in response to increasing Mn2+ levels (PubMed:19924247). Reduced survival rate in response to high Mn2+ levels or to infection mediated by pathogenic bacterium S.aureus (PubMed:19785996). Increased smf-2 mRNA levels (PubMed:19924247). RNAi-mediated knockdown increases resistance to Mn2+-induced CEP neuron death and prevents CEP neuron death-mediated by the neurotoxin 6-hydroxy dopamine (6-OHDA) (PubMed:19801673).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002126071 – 562NRAMP-like transporter smf-1Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi334N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi422N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21434

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in dopaminergic neurons (at protein level) (PubMed:19801673). Expressed predominantly in anterior and posterior intestine, rectal gland cell, H-shaped excretory cell, vulva cells, proximal uterus and spermatheca in adults (PubMed:19924247, PubMed:19785996). Weakly expressed in hyp7 hypodermis, pharyngeal muscles and some anterior sensory, ring and posterior head neurons in adults (PubMed:19924247, PubMed:19785996). Expressed in the anchor cell at the larval stage (PubMed:19924247).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at the embryonic comma stage and throughout larval and adult stages.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by pathogenic bacterium S.aureus (PubMed:19785996). Repressed by high levels of Mn2+ (PubMed:19801673, PubMed:19924247).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004876, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.K11G12.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1291, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170016

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020088_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21434

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENDAPWL

Database of Orthologous Groups

More...
OrthoDBi
666470at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q21434

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00221, NRAMP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001046, NRAMP_fam

The PANTHER Classification System

More...
PANTHERi
PTHR11706, PTHR11706, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01566, Nramp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00447, NATRESASSCMP

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01197, nramp, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q21434-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSNNDGPI EPEAEPWRIT QNDHLEQDLL EEDAESQERV DIPVDDVEKA
60 70 80 90 100
FSFKKLWAFT GPGFLMSIAY LDPGNIESDL QSGAQAAYKL LWVLLSAHII
110 120 130 140 150
GMLLQRMSAR LGVVSGKHMA EVAYQFYPRL PRIILWLMIE IAIVCSDMQE
160 170 180 190 200
VIGTAIAIFL LSKGFVPLYV GVFITILDTF TFLLIDRYGI RKLELIFGFL
210 220 230 240 250
ILTMTVSFGY EFVVVKPPIG EVISGMVVPW CAGCGKGEFM QAISVVGAVI
260 270 280 290 300
MPHNLYLHSA LVKSRRVDRK DRRRVAEANK YFTLESAIAL FLSFFINLFV
310 320 330 340 350
VAVFAHGLYQ KTNADVREMC IARHDIPDAD IFPNNTEPVE VDIYKGGIYL
360 370 380 390 400
GCQFGAIAMF IWGIGIFAAG QSSTMTGTYT GQFVMEGFVK IEWPKWKRVL
410 420 430 440 450
ITRAIAITPT LVLTFYSQGV QNLTGMNDFL NCVQMIQLPF ALIPIITFTS
460 470 480 490 500
SRKIMHDFRS SKVFQIFALI TSALILSINV YFISDYVFSR LGSEWYIIMV
510 520 530 540 550
LAPITFAYVL FVLYLALYCL VSCEIIPDTV SIRGFSFNKS YENDAPWLAV
560
DSSAVHDNAG YQ
Length:562
Mass (Da):63,104
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C49AFB160285FF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081325 Genomic DNA Translation: CCD70800.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16619

NCBI Reference Sequences

More...
RefSeqi
NP_001024792.2, NM_001029621.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K11G12.4a.1; K11G12.4a.1; WBGene00004876

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180939

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K11G12.4

UCSC genome browser

More...
UCSCi
K11G12.4b, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081325 Genomic DNA Translation: CCD70800.1
PIRiT16619
RefSeqiNP_001024792.2, NM_001029621.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.K11G12.4a

Protein family/group databases

TCDBi2.A.55.2.16, the metal ion (mn(2+)-iron) transporter (nramp) family

Proteomic databases

PaxDbiQ21434

Genome annotation databases

EnsemblMetazoaiK11G12.4a.1; K11G12.4a.1; WBGene00004876
GeneIDi180939
KEGGicel:CELE_K11G12.4
UCSCiK11G12.4b, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180939
WormBaseiK11G12.4a ; CE41828 ; WBGene00004876 ; smf-1

Phylogenomic databases

eggNOGiKOG1291, Eukaryota
GeneTreeiENSGT00940000170016
HOGENOMiCLU_020088_5_2_1
InParanoidiQ21434
OMAiENDAPWL
OrthoDBi666470at2759
PhylomeDBiQ21434

Enzyme and pathway databases

ReactomeiR-CEL-1222556, ROS and RNS production in phagocytes
R-CEL-425410, Metal ion SLC transporters
R-CEL-6798695, Neutrophil degranulation
R-CEL-6803544, Ion influx/efflux at host-pathogen interface
R-CEL-917937, Iron uptake and transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21434

Gene expression databases

BgeeiWBGene00004876, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

HAMAPiMF_00221, NRAMP, 1 hit
InterProiView protein in InterPro
IPR001046, NRAMP_fam
PANTHERiPTHR11706, PTHR11706, 1 hit
PfamiView protein in Pfam
PF01566, Nramp, 1 hit
PRINTSiPR00447, NATRESASSCMP
TIGRFAMsiTIGR01197, nramp, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRAMA_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21434
Secondary accession number(s): Q65ZJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 8, 2008
Last modified: September 29, 2021
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again