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Entry version 131 (02 Jun 2021)
Sequence version 2 (13 Jun 2012)
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Protein

Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1

Gene

gpcp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1By similarity (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gpcp-1Imported
ORF Names:K10B3.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
K10B3.6a ; CE46326 ; WBGene00019612 ; gpcp-1
K10B3.6b ; CE46407 ; WBGene00019612 ; gpcp-1
K10B3.6c ; CE46481 ; WBGene00019612 ; gpcp-1
K10B3.6d ; CE46163 ; WBGene00019612 ; gpcp-1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004179191 – 690Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1CuratedAdd BLAST690

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21407

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21407

PeptideAtlas

More...
PeptideAtlasi
Q21407

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00019612, Expressed in adult organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.K10B3.6d.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21407

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 122CBM20PROSITE-ProRule annotationAdd BLAST122
Domaini344 – 654GP-PDEAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni670 – 690DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2421, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21407

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDICTMI

Database of Orthologous Groups

More...
OrthoDBi
1203055at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05814, CBM20_Prei4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.20.20.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013784, Carb-bd-like_fold
IPR034839, CBM20_GPCPD1
IPR002044, CBM_fam20
IPR030395, GP_PDE_dom
IPR013783, Ig-like_fold
IPR017946, PLC-like_Pdiesterase_TIM-brl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00686, CBM_20, 1 hit
PF03009, GDPD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01065, CBM_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49452, SSF49452, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51166, CBM20, 1 hit
PS51704, GP_PDE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform d (identifier: Q21407-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQDYKAHFK VFCSEVREWE KIHVVGSLPV LGEWNPRKSF PLTKSTDEEN
60 70 80 90 100
TFHAIVSVPS SIKEFNFRYI RVMYLDPSEN NTSEPIMVLS KWETFNNART
110 120 130 140 150
CLIGVESQDG VARKNITDQF GSYSGKTQIT DGWILNEKES VVYFRIHGEA
160 170 180 190 200
LKFFAKSYAN KEYRLKVEPF DVRYSEMFSY TRKDITDRRG VWRHSSVYAS
210 220 230 240 250
MSIDGDDVVN LPTPSLPCFS NTDLSVLTRE DPIFGDQYFN GSVFRNDQDY
260 270 280 290 300
LVFRTRTVSL QNLAFRIEFY HGEKRCALSY VLPSSMSGTH GATVSPVIGL
310 320 330 340 350
SSAPVGHINV NYMIVKRNKY TDQNLDIDSM KTTFGRYWRK RNRMLQIGHR
360 370 380 390 400
GMGSSYTKNI GQRENTIFSL NEAARRGADY VEMDVQLTKD LKTVVYHDFH
410 420 430 440 450
VLVAVAGRDS PSSTPTAAGE NKSLHEIAIK DLTLAQLNLL HFEHISRANG
460 470 480 490 500
SSAESPVALS VTPSKTETDE LHVPFPSLAQ VLRHVDENVG LNIEIKYPMY
510 520 530 540 550
MQDGSHECQG YFEQNKFVDI ILAEVAEHAG NRRIIFSCFE PDICTMITKK
560 570 580 590 600
QHKYPVSFLV VGATNRYMPF QDIRSDCSKI AANFAAGCEL LGVNFHSEEL
610 620 630 640 650
LIDQKPIEIA EKYGLIKFVW GDDLNSKEVQ KHFRDEMNVD GLIFDRIGED
660 670 680 690
EVLKQNVFVV ENHNRSSLFA RSQHNSRSPS MSRRCMSTVE
Length:690
Mass (Da):78,735
Last modified:June 13, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6D0E1100EE399D4
GO
Isoform a (identifier: Q21407-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-202: Missing.

Show »
Length:664
Mass (Da):75,615
Checksum:i25F406FB3EF5916E
GO
Isoform b (identifier: Q21407-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-202: Missing.
     359-432: NIGQRENTIF...SLHEIAIKDL → FVESAGDPFLNLNSE
     436-443: QLNLLHFE → KERTLYFP
     444-690: Missing.

Show »
Length:358
Mass (Da):41,145
Checksum:iAD24281A9C8CD6B5
GO
Isoform c (identifier: Q21407-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-178: MF → VS
     179-690: Missing.

Show »
Length:178
Mass (Da):20,712
Checksum:iBC214847F2683895
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043935177 – 202Missing in isoform a and isoform b. CuratedAdd BLAST26
Alternative sequenceiVSP_043936177 – 178MF → VS in isoform c. Curated2
Alternative sequenceiVSP_043937179 – 690Missing in isoform c. CuratedAdd BLAST512
Alternative sequenceiVSP_043938359 – 432NIGQR…AIKDL → FVESAGDPFLNLNSE in isoform b. CuratedAdd BLAST74
Alternative sequenceiVSP_043939436 – 443QLNLLHFE → KERTLYFP in isoform b. Curated8
Alternative sequenceiVSP_043940444 – 690Missing in isoform b. CuratedAdd BLAST247

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080552 Genomic DNA Translation: CCD64603.1
FO080552 Genomic DNA Translation: CCD64604.1
FO080552 Genomic DNA Translation: CCD64605.1
FO080552 Genomic DNA Translation: CCD64606.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T16609

NCBI Reference Sequences

More...
RefSeqi
NP_001024784.2, NM_001029613.2 [Q21407-2]
NP_001024785.2, NM_001029614.3
NP_001024786.2, NM_001029615.2
NP_001256998.1, NM_001270069.1 [Q21407-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K10B3.6a.1; K10B3.6a.1; WBGene00019612 [Q21407-2]
K10B3.6b.1; K10B3.6b.1; WBGene00019612 [Q21407-3]
K10B3.6c.1; K10B3.6c.1; WBGene00019612 [Q21407-4]
K10B3.6d.1; K10B3.6d.1; WBGene00019612 [Q21407-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K10B3.6

UCSC genome browser

More...
UCSCi
K10B3.6a, c. elegans [Q21407-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080552 Genomic DNA Translation: CCD64603.1
FO080552 Genomic DNA Translation: CCD64604.1
FO080552 Genomic DNA Translation: CCD64605.1
FO080552 Genomic DNA Translation: CCD64606.1
PIRiT16609
RefSeqiNP_001024784.2, NM_001029613.2 [Q21407-2]
NP_001024785.2, NM_001029614.3
NP_001024786.2, NM_001029615.2
NP_001256998.1, NM_001270069.1 [Q21407-1]

3D structure databases

SMRiQ21407
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.K10B3.6d.2

Proteomic databases

EPDiQ21407
PaxDbiQ21407
PeptideAtlasiQ21407

Genome annotation databases

EnsemblMetazoaiK10B3.6a.1; K10B3.6a.1; WBGene00019612 [Q21407-2]
K10B3.6b.1; K10B3.6b.1; WBGene00019612 [Q21407-3]
K10B3.6c.1; K10B3.6c.1; WBGene00019612 [Q21407-4]
K10B3.6d.1; K10B3.6d.1; WBGene00019612 [Q21407-1]
GeneIDi180600
KEGGicel:CELE_K10B3.6
UCSCiK10B3.6a, c. elegans [Q21407-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180600
WormBaseiK10B3.6a ; CE46326 ; WBGene00019612 ; gpcp-1
K10B3.6b ; CE46407 ; WBGene00019612 ; gpcp-1
K10B3.6c ; CE46481 ; WBGene00019612 ; gpcp-1
K10B3.6d ; CE46163 ; WBGene00019612 ; gpcp-1

Phylogenomic databases

eggNOGiKOG2421, Eukaryota
InParanoidiQ21407
OMAiPDICTMI
OrthoDBi1203055at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21407

Gene expression databases

BgeeiWBGene00019612, Expressed in adult organism and 4 other tissues

Family and domain databases

CDDicd05814, CBM20_Prei4, 1 hit
Gene3Di2.60.40.10, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR013784, Carb-bd-like_fold
IPR034839, CBM20_GPCPD1
IPR002044, CBM_fam20
IPR030395, GP_PDE_dom
IPR013783, Ig-like_fold
IPR017946, PLC-like_Pdiesterase_TIM-brl
PfamiView protein in Pfam
PF00686, CBM_20, 1 hit
PF03009, GDPD, 1 hit
SMARTiView protein in SMART
SM01065, CBM_2, 1 hit
SUPFAMiSSF49452, SSF49452, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS51166, CBM20, 1 hit
PS51704, GP_PDE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPCP1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21407
Secondary accession number(s): G4S033, H2KYS5, H2KYS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: June 13, 2012
Last modified: June 2, 2021
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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