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Protein

Zinc metalloproteinase nas-10

Gene

nas-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metalloprotease.By similarity

Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi414Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Active sitei415PROSITE-ProRule annotation1
Metal bindingi418Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Metal bindingi424Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM12.A35

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-10 (EC:3.4.24.-By similarity)
Alternative name(s):
Nematode astacin 10
Gene namesi
Name:nas-10
ORF Names:K09C8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK09C8.3a ; CE03479 ; WBGene00003529 ; nas-10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000078185? – 560Zinc metalloproteinase nas-10
PropeptideiPRO_00004426571 – ?Curated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi359 ↔ 519PROSITE-ProRule annotation
Disulfide bondi385 ↔ 405PROSITE-ProRule annotation
Disulfide bondi524 ↔ 560PROSITE-ProRule annotation
Disulfide bondi531 ↔ 553PROSITE-ProRule annotation
Disulfide bondi540 ↔ 557PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ21388

Expressioni

Gene expression databases

BgeeiWBGene00003529 Expressed in 3 organ(s), highest expression level in material anatomical entity

Structurei

3D structure databases

ProteinModelPortaliQ21388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 520Peptidase M12APROSITE-ProRule annotationAdd BLAST208
Domaini524 – 560ShKTPROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 114Poly-ProSequence analysis4
Compositional biasi187 – 227Gln-richPROSITE-ProRule annotationAdd BLAST41

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119227
HOGENOMiHOG000018720
InParanoidiQ21388
KOiK08076
OMAiAVNIAKP
OrthoDBiEOG091G05O5
PhylomeDBiQ21388

Family and domain databases

CDDicd04280 ZnMc_astacin_like, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR034035 Astacin-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR017368 Peptidase_M12A_astacin-9/10/11
IPR006026 Peptidase_Metallo
IPR003582 ShKT_dom
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF01549 ShK, 1 hit
PIRSFiPIRSF038055 Nas9/Nas10/Nas11, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00254 ShKT, 1 hit
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS51670 SHKT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q21388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYTITDLKTI NRKQKQAYLQ EKLICSRHCW LTHTTSKHIN IQWTTLIPHI
60 70 80 90 100
RCRGFNNGPH PNSRPGSRPN SPLGDIFGNI NGMVKGITDQ IGKIAQGLDV
110 120 130 140 150
NNDLGKMAHG PPPPQSEWVE HARRFCRRFP GHPKCRGQLP QFNDIGSMLN
160 170 180 190 200
GILVDSGKWL PKVPFINIRD PLSGINSDLK NALNGIQVQF GQISQQFANN
210 220 230 240 250
IRNICQQMNC KQQQQKNVQM KQAILKQTVD FEKKVFGNNV ADKMNLRFDR
260 270 280 290 300
TLQLKQALLE KAQLKGVVAP EDNGVFDKDL LLTETQANFM LNELGKGGEG
310 320 330 340 350
AIPMPGSAKA KRASIFFEQN LIQKWPSTSP IPYTFDSSLD NLDQNDVRGA
360 370 380 390 400
ISEIEQKTCI RFKYFASPPK GNHINYQKVN SPSFCGLSYI GRVEPANPVY
410 420 430 440 450
LSFQCGNGRG IAVHETMHAL GVNHQHLRMD RDKHIKVDWS NINPQQYDAF
460 470 480 490 500
VVADSKLYTT YGVKYAYDSI MHYNAYTGAV NIAKPTMIPL VNQQANIGLL
510 520 530 540 550
GQRAKMSNAD VEILNKMYCK SAGCDDKNVY CGAWALQDLC NNPNHNVWMR
560
SNCRKSCNFC
Length:560
Mass (Da):63,041
Last modified:November 1, 1996 - v1
Checksum:i4490B5456DA7256A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B6EU59B6EU59_CAEEL
Metalloendopeptidase
nas-10 CELE_K09C8.3, K09C8.3
540Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68006 Genomic DNA Translation: CAA91996.1
PIRiT23540
RefSeqiNP_001257125.1, NM_001270196.1
UniGeneiCel.696

Genome annotation databases

EnsemblMetazoaiK09C8.3a; K09C8.3a; WBGene00003529
GeneIDi181287
KEGGicel:CELE_K09C8.3
UCSCiK09C8.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68006 Genomic DNA Translation: CAA91996.1
PIRiT23540
RefSeqiNP_001257125.1, NM_001270196.1
UniGeneiCel.696

3D structure databases

ProteinModelPortaliQ21388
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.A35

Proteomic databases

PaxDbiQ21388

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK09C8.3a; K09C8.3a; WBGene00003529
GeneIDi181287
KEGGicel:CELE_K09C8.3
UCSCiK09C8.3 c. elegans

Organism-specific databases

CTDi181287
WormBaseiK09C8.3a ; CE03479 ; WBGene00003529 ; nas-10

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119227
HOGENOMiHOG000018720
InParanoidiQ21388
KOiK08076
OMAiAVNIAKP
OrthoDBiEOG091G05O5
PhylomeDBiQ21388

Miscellaneous databases

PROiPR:Q21388

Gene expression databases

BgeeiWBGene00003529 Expressed in 3 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd04280 ZnMc_astacin_like, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR034035 Astacin-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR017368 Peptidase_M12A_astacin-9/10/11
IPR006026 Peptidase_Metallo
IPR003582 ShKT_dom
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF01549 ShK, 1 hit
PIRSFiPIRSF038055 Nas9/Nas10/Nas11, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00254 ShKT, 1 hit
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS51670 SHKT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAS10_CAEEL
AccessioniPrimary (citable) accession number: Q21388
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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