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Protein
Submitted name:

Acyl CoA DeHydrogenase

Gene

acdh-8

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

FADUniRule annotation

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: UniProtKB-UniRule
  • medium-chain-acyl-CoA dehydrogenase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

ReactomeiR-CEL-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
R-CEL-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
R-CEL-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA

Names & Taxonomyi

Protein namesi
Submitted name:
Acyl CoA DeHydrogenaseImported
Gene namesi
Name:acdh-8Imported
ORF Names:CELE_K05F1.3Imported, K05F1.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK05F1.3 ; CE02807 ; WBGene00019406 ; acdh-8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ21243
PaxDbiQ21243
PeptideAtlasiQ21243
PRIDEiQ21243

Expressioni

Gene expression databases

BgeeiWBGene00019406 Expressed in 3 organ(s), highest expression level in material anatomical entity

Interactioni

Protein-protein interaction databases

DIPiDIP-26267N
STRINGi6239.K05F1.3

Structurei

3D structure databases

ProteinModelPortaliQ21243
SMRiQ21243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 135Acyl-CoA_dh_NInterPro annotationAdd BLAST110
Domaini141 – 239Acyl-CoA_dh_MInterPro annotationAdd BLAST99
Domaini251 – 399Acyl-CoA_dh_1InterPro annotationAdd BLAST149

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0140 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131659
InParanoidiQ21243
KOiK00249
OMAiEKAGWID
OrthoDBiEOG091G04BS
PhylomeDBiQ21243

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q21243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTRLSSGTT WNRIAVQSRQ MSFELSDTQK EIQSHAIKFS KDVLVPNAAK
60 70 80 90 100
FDKSGEFPWE IVKQAHSLGF MNTIIPEKYG GPGLSNLDTA LIVEALSYGC
110 120 130 140 150
SGLQIAIFGP SLAAAPICLS GTEEQKKKYL GMLAAEPIIA SYCVTEPGAG
160 170 180 190 200
SDVNGVKTKA VKQGDEYIIN GSKAWITGGG HAKWFFVLAR TDDNPKTPAG
210 220 230 240 250
KAFTAFIVDG DTPGITRGKK ENNMGQRCSD TRSITFEDVR VPKENILGAP
260 270 280 290 300
GAGFKVAMGA FDLTRPQVAA SAVGLAWRCL DESTKYAMER HAFGTPIANH
310 320 330 340 350
QGVQFMIADM AINLELSRLF TYRAAAEVDS YGVSSYNASI AKCFAADTAN
360 370 380 390 400
VAATNACQIF GGAGFNCEYP VEKLMRDAKI YQIYEGTSQI QRMVIGRTLF
410
QNFAKNGTSK MT
Length:412
Mass (Da):44,496
Last modified:November 1, 1996 - v1
Checksum:i276EE22A51B84188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD69143.1
PIRiT16568
RefSeqiNP_495142.1, NM_062741.6
UniGeneiCel.14814

Genome annotation databases

EnsemblMetazoaiK05F1.3; K05F1.3; WBGene00019406
GeneIDi173979
KEGGicel:CELE_K05F1.3
UCSCiK05F1.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD69143.1
PIRiT16568
RefSeqiNP_495142.1, NM_062741.6
UniGeneiCel.14814

3D structure databases

ProteinModelPortaliQ21243
SMRiQ21243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26267N
STRINGi6239.K05F1.3

Proteomic databases

EPDiQ21243
PaxDbiQ21243
PeptideAtlasiQ21243
PRIDEiQ21243

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK05F1.3; K05F1.3; WBGene00019406
GeneIDi173979
KEGGicel:CELE_K05F1.3
UCSCiK05F1.3 c. elegans

Organism-specific databases

CTDi173979
WormBaseiK05F1.3 ; CE02807 ; WBGene00019406 ; acdh-8

Phylogenomic databases

eggNOGiKOG0140 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131659
InParanoidiQ21243
KOiK00249
OMAiEKAGWID
OrthoDBiEOG091G04BS
PhylomeDBiQ21243

Enzyme and pathway databases

ReactomeiR-CEL-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
R-CEL-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
R-CEL-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA

Gene expression databases

BgeeiWBGene00019406 Expressed in 3 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ21243_CAEEL
AccessioniPrimary (citable) accession number: Q21243
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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