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Entry version 144 (17 Jun 2020)
Sequence version 2 (02 Sep 2008)
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Protein

Adenomatous polyposis coli protein-related protein 1

Gene

apr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in endoderm cell specification and pharyngeal development (PubMed:9288750). Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation (PubMed:20805471). During larval development, apr-1 is required for expression of lin-39 in P3-8.p (PubMed:10766743). Shown to negatively regulate Wnt signaling in vulval precursor cells (PubMed:12023306). Has a role in cell division by establishing the polarity of the mother cell which forms the asymmetries of the daughter nuclei (PubMed:17276345). Thought to regulate export of wrm-1 from the nucleus possibly as part of a complex involving pry-1 (PubMed:12023307).6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Protein transport, Transport, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-195253 Degradation of beta-catenin by the destruction complex
R-CEL-196299 Beta-catenin phosphorylation cascade
R-CEL-3769402 Deactivation of the beta-catenin transactivating complex

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q21227

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenomatous polyposis coli protein-related protein 1
Short name:
APC-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:apr-1Imported
ORF Names:K04G2.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
K04G2.8a ; CE06102 ; WBGene00000156 ; apr-1
K04G2.8b ; CE18016 ; WBGene00000156 ; apr-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit lack of endoderm, excessive pharyngeal tissue and premature division of the E daughter blastomeres during embryogenesis. Two-thirds arrest during embryogenesis and the remaining third during the L1 stage (PubMed:9288750). RNAi-mediated knockdown causes partial nuclear re-localization of hmp-2 in the embryonic epidermis and the production of supernumerary gut nuclei probably resulting from epithelial cell hyperproliferation (PubMed:20805471).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003472501 – 1188Adenomatous polyposis coli protein-related protein 1Add BLAST1188

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21227

PeptideAtlas

More...
PeptideAtlasi
Q21227

PRoteomics IDEntifications database

More...
PRIDEi
Q21227

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During the L1 stage, expressed in vulval precursor cells (P3-8.p), seam cells and excretory cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000156 Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q21227 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with bar-1 and hmp-2; the interaction with hmp-2 is relatively weak.

Interacts (via C-terminus) with pry-1 (via N-terminus). Probably associates with bar-1, gsk-3, pry-1 in a complex.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
38025, 23 interactors

Database of interacting proteins

More...
DIPi
DIP-41257N

Protein interaction database and analysis system

More...
IntActi
Q21227, 19 interactors

STRING: functional protein association networks

More...
STRINGi
6239.K04G2.8b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21227

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati314 – 358ARMSequence analysisAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 486Required for interaction with bar-1 and hmp-21 PublicationAdd BLAST486
Regioni600 – 1188Required for interaction with pry-11 PublicationAdd BLAST589

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi491 – 589Gln-richSequence analysisAdd BLAST99
Compositional biasi953 – 996Asp-richSequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenomatous polyposis coli (APC) family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2122 Eukaryota
ENOG410XR2V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063749

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21227

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHSVENK

Database of Orthologous Groups

More...
OrthoDBi
268832at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026818 Apc_fam
IPR011989 ARM-like
IPR016024 ARM-type_fold

The PANTHER Classification System

More...
PANTHERi
PTHR12607 PTHR12607, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform b1 Publication (identifier: Q21227-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSSSDENE TTIHRTGSNT GGSGIYSQPR AGSSKRTSNV RHDVSDVDDE
60 70 80 90 100
EEHYARFRED TAIEVDDAIT VLLSSLHFEH KRDIVPTDED DNKLRELHEK
110 120 130 140 150
IFALITSESD VNRKRRLKKA LPASNCVREQ VYYLRRKPST PPASYYHRLN
160 170 180 190 200
AALHTIVKES FGEEYRKVAT VLGLVEALAE VLILEVHTFG INETNPGEHR
210 220 230 240 250
NIRKLIANAL TNLTYGQIHS KRRLCSYDGF IRCVVRIVIE SPNITQVYAG
260 270 280 290 300
LIRNLSWNAD SGMSEALQPT VHALSIAAVH AHTHRFDVTA TLSALWNLAG
310 320 330 340 350
HSVENKRTIC DTPNCLKVLA SLLSPDARFT SLVDSATGIL KYVSQYLANT
360 370 380 390 400
STHLELRSLL ITRMLTLLKS ASFTCVTNTL GAIANLIVKD PHMQQMIRQD
410 420 430 440 450
MAAVQQLNVL RNSNRDDIRT AVKSVLNTLN QPCSHRYGDM SHSVGGGATG
460 470 480 490 500
MQMLSEPQLQ MQTSHHAYHG TASPRLLSLR ATRASPGKYI QPQAQQQLIQ
510 520 530 540 550
TPQVDQRSSS LPRHFAVQRN GFVMAQSYNQ QMDQHQQQQM IYQLQQQQQI
560 570 580 590 600
MFQTEDQAQM EHHQQIMYLQ QQQQQFHQIQ QQQQMQKAQE ADPVPPTDDD
610 620 630 640 650
LDIPTSTVMG TRSNSERSLG SMNPGSVMTN WNSSLDTAAN SSRALSPVSY
660 670 680 690 700
NDIPASPTMC AQVFNLPKST ESEHHQLTSQ QQNTTHYSSG SANTMTRSDG
710 720 730 740 750
ATTVPMDNII TPTYAILNPI LVHEQTPNGT VPRKTSEELD SPDDVLPGPS
760 770 780 790 800
LEEEEGDYAI IGGAAQKTDD ELLTRSIQSE MPTSSSTPKM KVSPRLNGFF
810 820 830 840 850
SPTQKTTSSP AWSHPDTSPI PKSSSHRTQP NRRQDASDAD RLLMESIMSE
860 870 880 890 900
MPKSRIISPR LAGTQQYLEP EPERRSHSKN EEADRRDAFT ASHEPSDHNG
910 920 930 940 950
IDVARGSDWS PQQQLHRMES LESQASSEDS FGLTAEEPNS STSGAAANTM
960 970 980 990 1000
RFDDEIDASL PMDCVDDDDY DYTYDHFEDY EDEEDPDATQ FDDGVDAQLT
1010 1020 1030 1040 1050
IDCSMISSGS GSSQRNETTT TSRDSKALAT STPKGSASSL PGVRQATRVS
1060 1070 1080 1090 1100
TNGKSRLPVP KTNGSLVDKN PKPIIASRRP RLPPKPTLLK DKHYPEEDSI
1110 1120 1130 1140 1150
ENQTRDDTIY VNAPVVEAEQ ERIYMNALKQ QKNIEQSPSI GNGSPIAKSA
1160 1170 1180
IVTPYNYQKP PFTGRNNGEM SNEKSVTPNP KQMLVTIV
Length:1,188
Mass (Da):131,990
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3CDA53B5D3527A0
GO
Isoform a1 Publication (identifier: Q21227-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     552-553: Missing.

Show »
Length:1,186
Mass (Da):131,714
Checksum:iCBE672D78E2B245D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1I6CM53A0A1I6CM53_CAEEL
Adenomatous polyposis coli protein-...
apr-1 CELE_K04G2.8, K04G2.8
892Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052859552 – 553Missing in isoform a. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF013950 mRNA Translation: AAC47747.1
Z75712 Genomic DNA Translation: CAB00045.1
Z75712 Genomic DNA Translation: CAB00048.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T23327
T23330

NCBI Reference Sequences

More...
RefSeqi
NP_001021547.1, NM_001026376.4 [Q21227-1]
NP_492217.2, NM_059816.4 [Q21227-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K04G2.8a.1; K04G2.8a.1; WBGene00000156 [Q21227-2]
K04G2.8b.1; K04G2.8b.1; WBGene00000156 [Q21227-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172591

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K04G2.8

UCSC genome browser

More...
UCSCi
K04G2.8b c. elegans [Q21227-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013950 mRNA Translation: AAC47747.1
Z75712 Genomic DNA Translation: CAB00045.1
Z75712 Genomic DNA Translation: CAB00048.1
PIRiT23327
T23330
RefSeqiNP_001021547.1, NM_001026376.4 [Q21227-1]
NP_492217.2, NM_059816.4 [Q21227-2]

3D structure databases

SMRiQ21227
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi38025, 23 interactors
DIPiDIP-41257N
IntActiQ21227, 19 interactors
STRINGi6239.K04G2.8b

Proteomic databases

PaxDbiQ21227
PeptideAtlasiQ21227
PRIDEiQ21227

Genome annotation databases

EnsemblMetazoaiK04G2.8a.1; K04G2.8a.1; WBGene00000156 [Q21227-2]
K04G2.8b.1; K04G2.8b.1; WBGene00000156 [Q21227-1]
GeneIDi172591
KEGGicel:CELE_K04G2.8
UCSCiK04G2.8b c. elegans [Q21227-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172591
WormBaseiK04G2.8a ; CE06102 ; WBGene00000156 ; apr-1
K04G2.8b ; CE18016 ; WBGene00000156 ; apr-1

Phylogenomic databases

eggNOGiKOG2122 Eukaryota
ENOG410XR2V LUCA
GeneTreeiENSGT00530000063749
InParanoidiQ21227
OMAiGHSVENK
OrthoDBi268832at2759

Enzyme and pathway databases

ReactomeiR-CEL-195253 Degradation of beta-catenin by the destruction complex
R-CEL-196299 Beta-catenin phosphorylation cascade
R-CEL-3769402 Deactivation of the beta-catenin transactivating complex
SignaLinkiQ21227

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21227

Gene expression databases

BgeeiWBGene00000156 Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues
ExpressionAtlasiQ21227 differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026818 Apc_fam
IPR011989 ARM-like
IPR016024 ARM-type_fold
PANTHERiPTHR12607 PTHR12607, 3 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPR1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21227
Secondary accession number(s): O62302
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 17, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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