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Entry version 130 (18 Sep 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Intermediate filament protein ifa-3

Gene

ifa-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures.2 Publications

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-4419969 Depolymerisation of the Nuclear Lamina

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intermediate filament protein ifa-3
Alternative name(s):
Cel IF A3
Intermediate filament protein A3
Short name:
IF-A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ifa-3
ORF Names:F52E10.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
F52E10.5 ; CE34875 ; WBGene00002051 ; ifa-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Intermediate filament

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000638361 – 581Intermediate filament protein ifa-3Add BLAST581

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21065

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21065

PeptideAtlas

More...
PeptideAtlasi
Q21065

PRoteomics IDEntifications database

More...
PRIDEi
Q21065

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q21065

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the embryonic and larval hypodermis. Also expressed in the ventral nerve cord of larvae.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryos and larvae. Not expressed in adults.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002051 Expressed in 3 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms some heteropolymeric filaments with ifb-1.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F52E10.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21065

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 424IF rodPROSITE-ProRule annotationAdd BLAST354
Domaini457 – 574LTDPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 74HeadAdd BLAST74
Regioni75 – 106Coil 1AAdd BLAST32
Regioni107 – 120Linker 1Add BLAST14
Regioni121 – 258Coil 1BAdd BLAST138
Regioni259 – 276Linker 12Add BLAST18
Regioni277 – 424Coil 2Add BLAST148
Regioni425 – 578TailAdd BLAST154

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0977 Eukaryota
ENOG410Y2H6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000196730

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000017007

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21065

KEGG Orthology (KO)

More...
KOi
K18585

Identification of Orthologs from Complete Genome Data

More...
OMAi
MTTEYER

Database of Orthologous Groups

More...
OrthoDBi
701388at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q21065

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 2 hits
2.60.40.1260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR016451 Intermed_filament_ifa/ifb
IPR001322 Lamin_tail_dom
IPR036415 Lamin_tail_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit
PF00932 LTD, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005546 Intermed_filamnt_Ifb-2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74853 SSF74853, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51842 IF_ROD_2, 1 hit
PS51841 LTD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q21065-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPDSYRSS ITSRPAFNRT VTSSTQNYGT PASGNRVLKI VTETHTSSVA
60 70 80 90 100
SGLSPYGQGA ASTIRDDRER EKKEITELND RLASYIGKVR FLAAQNRKLE
110 120 130 140 150
ADLNVLQSRF GKSTGSVKIM YEMEITTATN VVKETGKDHE EAEKEIGKIK
160 170 180 190 200
DQLDELRKKF EEAQKGRAED RLKIDELLVT LSNLEAEINL LKRRIALLEE
210 220 230 240 250
EVARLKKENF RLTSELQRVR SELDQETLLR IDNQNKVTTI LEEIDFMKRG
260 270 280 290 300
FETELKDLQA QAARDTTSEN REYFKNELMN SIRDIRAEYD RFMAGNRNDL
310 320 330 340 350
ESWSQIRVQE INTQTNRQNA EINHKRDEVK RLHSQVSELK SKHAELAARN
360 370 380 390 400
GLLEKQLEDL NYQLEDDQRS YEAALNDKDA QVRKLREECQ ALLVELQMLL
410 420 430 440 450
DTKQTLDGEL KVYRRMLEGN SEENGLRQLV EKVVRTSAIN EEVDTETMRV
460 470 480 490 500
VKGEHSSRTS YQRSAKGNVS IKEVSPEGKF VILENTHRDK EEPLGDWKLK
510 520 530 540 550
RKIDGKREIV FTFPSDYILH PVQTVKIFAR GNGVANPPEV LVFEGDDTFG
560 570 580
AGANVQTILY NNSGEERATH MQRQSQQTTT S
Length:581
Mass (Da):66,563
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECF989B21E460C7F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X70831 Genomic DNA Translation: CAA50179.1
Z54282, Z81140 Genomic DNA Translation: CAA91057.4

Protein sequence database of the Protein Information Resource

More...
PIRi
S46327
T22507

NCBI Reference Sequences

More...
RefSeqi
NP_510649.3, NM_078248.7

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F52E10.5.1; F52E10.5.1; WBGene00002051

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181699

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F52E10.5

UCSC genome browser

More...
UCSCi
F52E10.5 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70831 Genomic DNA Translation: CAA50179.1
Z54282, Z81140 Genomic DNA Translation: CAA91057.4
PIRiS46327
T22507
RefSeqiNP_510649.3, NM_078248.7

3D structure databases

SMRiQ21065
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F52E10.5

PTM databases

iPTMnetiQ21065

Proteomic databases

EPDiQ21065
PaxDbiQ21065
PeptideAtlasiQ21065
PRIDEiQ21065

Genome annotation databases

EnsemblMetazoaiF52E10.5.1; F52E10.5.1; WBGene00002051
GeneIDi181699
KEGGicel:CELE_F52E10.5
UCSCiF52E10.5 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181699
WormBaseiF52E10.5 ; CE34875 ; WBGene00002051 ; ifa-3

Phylogenomic databases

eggNOGiKOG0977 Eukaryota
ENOG410Y2H6 LUCA
GeneTreeiENSGT00970000196730
HOGENOMiHOG000017007
InParanoidiQ21065
KOiK18585
OMAiMTTEYER
OrthoDBi701388at2759
PhylomeDBiQ21065

Enzyme and pathway databases

ReactomeiR-CEL-4419969 Depolymerisation of the Nuclear Lamina

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q21065

Gene expression databases

BgeeiWBGene00002051 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.20.5.1160, 2 hits
2.60.40.1260, 1 hit
InterProiView protein in InterPro
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR016451 Intermed_filament_ifa/ifb
IPR001322 Lamin_tail_dom
IPR036415 Lamin_tail_dom_sf
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF00932 LTD, 1 hit
PIRSFiPIRSF005546 Intermed_filamnt_Ifb-2, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
SUPFAMiSSF74853 SSF74853, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit
PS51841 LTD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFA3_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21065
Secondary accession number(s): Q20671, Q94367
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: September 18, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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