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Entry version 135 (31 Jul 2019)
Sequence version 3 (04 Apr 2006)
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Protein

Vacuolar protein sorting-associated protein 35

Gene

vps-35

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in vesicular protein sorting.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportUniRule annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3238698 WNT ligand biogenesis and trafficking

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 35UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vps-35Imported
ORF Names:CELE_F59G1.3Imported, F59G1.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F59G1.3 ; CE39945 ; WBGene00006933 ; vps-35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21053

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21053

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00006933 Expressed in 5 organ(s), highest expression level in adult organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q21053 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F59G1.3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili781 – 801Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS35 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1107 Eukaryota
ENOG410XNXC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007315

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21053

KEGG Orthology (KO)

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KOi
K18468

Identification of Orthologs from Complete Genome Data

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OMAi
HLWWATP

Database of Orthologous Groups

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OrthoDBi
316875at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q21053

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.660, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR005378 Vps35
IPR042491 Vps35_C

The PANTHER Classification System

More...
PANTHERi
PTHR11099 PTHR11099, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03635 Vps35, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF009375 Retromer_Vps35, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q21053-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYENSGNTTD QEKFLDQSIR VVKAESFEMK RCLDKGKTMD ALKHALQMLN
60 70 80 90 100
EMRTAELSPK FYYRLYMDSM HELQCLEVNL VQEYAQEPAK LGNLYECVQY
110 120 130 140 150
ASAIIPRLYL LVTIGGVFIK CGLGSRKEIL KDLVEMCRGV QHPLRGLFLR
160 170 180 190 200
NYLMQCTRSV LPDFPETEEM LVAHNDNLSK GTPKLKPRDG TVDDTIDFVL
210 220 230 240 250
INFAEMNKLW VRMQHQGPSK EKEKREKDRM ELRILVGTNL VRLAQLEALT
260 270 280 290 300
EEMYVKDVLP SILEQIVSCR DPISQEYLME CVIQVFADDF HLATLTEFLN
310 320 330 340 350
ACGQLQQDVN IKILLIALVD RLALYTTSYN EGQPAPTKMQ LFEIFSEQAT
360 370 380 390 400
TLIKNRPDMP LDDIVALHVS LVSLAVKCYP DRQDYANMTF QGLRQVIEEK
410 420 430 440 450
GVTDIEAFGK VGRELTKLLN IPIDEYKNVL RLSQLPEYIK VMNYFDYRGQ
460 470 480 490 500
CNIASYMIQN MLEEETVFRN QDDVDSAFSL ISSLLKDQEK QSSDSHETEE
510 520 530 540 550
FADEQNLVAR LLHLIRADDV DSQFLLLNSA RKTLGEGGRH RLRYTLPPII
560 570 580 590 600
FELYRLVLQF SDMKDEDDKW DAKIRKMFVC AMGTIGALVS TAELAELPMK
610 620 630 640 650
LYLNGAITAD RVPFEDNHTV VYEFVSKALS ILEDDVVDSR DRVRCLHLTV
660 670 680 690 700
GTLLKTTHLP EENWQPLANQ TVLAAAKMFK KPDQVRSLVT VAALYWHGQT
710 720 730 740 750
LETNGEKMKN GKKVVDILRK AAKIARECLE PLVQQQLFIQ LLSAYTYYYE
760 770 780 790 800
DNCSEVNVDH IEELIARTQD NAVQLDVSAE ADSLEKQLGE AIRRLQLAKL
810 820
DVAAAQATTI RSEPELPQPP S
Length:821
Mass (Da):93,853
Last modified:April 4, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2CB7D41591BE492
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD70154.1

NCBI Reference Sequences

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RefSeqi
NP_495180.2, NM_062779.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F59G1.3.1; F59G1.3.1; WBGene00006933
F59G1.3.2; F59G1.3.2; WBGene00006933

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F59G1.3

UCSC genome browser

More...
UCSCi
F59G1.3 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD70154.1
RefSeqiNP_495180.2, NM_062779.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.F59G1.3

Proteomic databases

EPDiQ21053
PaxDbiQ21053

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59G1.3.1; F59G1.3.1; WBGene00006933
F59G1.3.2; F59G1.3.2; WBGene00006933
GeneIDi174000
KEGGicel:CELE_F59G1.3
UCSCiF59G1.3 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174000
WormBaseiF59G1.3 ; CE39945 ; WBGene00006933 ; vps-35

Phylogenomic databases

eggNOGiKOG1107 Eukaryota
ENOG410XNXC LUCA
GeneTreeiENSGT00390000007315
InParanoidiQ21053
KOiK18468
OMAiHLWWATP
OrthoDBi316875at2759
PhylomeDBiQ21053

Enzyme and pathway databases

ReactomeiR-CEL-3238698 WNT ligand biogenesis and trafficking

Gene expression databases

BgeeiWBGene00006933 Expressed in 5 organ(s), highest expression level in adult organism
ExpressionAtlasiQ21053 baseline

Family and domain databases

Gene3Di1.25.40.660, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005378 Vps35
IPR042491 Vps35_C
PANTHERiPTHR11099 PTHR11099, 1 hit
PfamiView protein in Pfam
PF03635 Vps35, 1 hit
PIRSFiPIRSF009375 Retromer_Vps35, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ21053_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21053
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: April 4, 2006
Last modified: July 31, 2019
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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