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Entry version 171 (29 Sep 2021)
Sequence version 4 (05 Oct 2010)
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Protein

Mitogen-activated protein kinase kinase kinase nsy-1

Gene

nsy-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1 (PubMed:11751572, PubMed:12142542, PubMed:21212236, PubMed:24448648).

Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons (PubMed:11336672, PubMed:11751572, PubMed:15625192).

Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection (PubMed:12142542, PubMed:18394898, PubMed:24448648).

Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796).

Probably by activating the sek1/pmk-1/skn-1 pathway, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection (PubMed:22216003).

Probably downstream of tir-1 and nipi-3, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:18394898).

Plays a role in resistance to several environmental stresses including oxidative, protein misfolding (ER) and osmotic stresses, and DNA-damaging reagents (PubMed:21212236, PubMed:15888317).

Plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress (PubMed:22308034).

Involved in germline apoptosis induced by heavy metals, such as Cu2+ (PubMed:19497412).

In addition, plays a role in the up-regulation of gcs-1 upon arsenite treatment, most likely through activation of pmk-1, to confer protection against toxicity induced by heavy metals (PubMed:25204677).

Plays a role downstream of tir-1 in regulating susceptibility to anoxia (PubMed:21212236).

Involved in egg laying (PubMed:12142542).

13 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei693ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei790Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi670 – 678ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processNeurogenesis, Stress response
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2559580, Oxidative Stress Induced Senescence

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q21029

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase nsy-1Curated (EC:2.7.11.252 Publications)
Alternative name(s):
Apoptosis signal-regulating kinase 11 Publication
Short name:
ASK-11 Publication
Neuronal symmetry kinase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nsy-1Imported
ORF Names:F59A6.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F59A6.1a ; CE44901 ; WBGene00003822 ; nsy-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in an increase in survival rate in anoxic conditions (PubMed:21212236). Upon infection by P.aeruginosa and E.faecalis, RNAi-mediated knockdown results in a moderate reduction in the up-regulation of gst-4 and gcs-1 expression (PubMed:22216003). Causes a severe reduction in rnt-1 accumulation in the intestine during oxidative stress mediated by paraquat (PubMed:22308034).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi693K → M: Loss of kinase activity. 2 Publications1
Mutagenesisi1003 – 1498Missing in ag3; reduces survival and reduces pmk-1 phosphorylation in response to the heavy metal arsenite. 1 PublicationAdd BLAST496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004338001 – 1498Mitogen-activated protein kinase kinase kinase nsy-1CuratedAdd BLAST1498

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated upon pathogenic bacterial infection. May be regulated by proteosomal degradation mediated by the E3-ubiquitin ligase rle-1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q21029

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q21029

PeptideAtlas

More...
PeptideAtlasi
Q21029

PRoteomics IDEntifications database

More...
PRIDEi
Q21029

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in intestine, hypodermis, rectal gland cell and neurons including sensory AWC neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003822, Expressed in material anatomical entity and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q21029, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with unc-43 (PubMed:11336672).

Interacts with sek-1 (PubMed:11751572).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q21029, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.F59A6.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q21029

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini664 – 925Protein kinasePROSITE-ProRule annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni190 – 209DisorderedSequence analysisAdd BLAST20
Regioni1022 – 1050DisorderedSequence analysisAdd BLAST29
Regioni1461 – 1498DisorderedSequence analysisAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1276 – 1314Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1027 – 1050Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4279, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171895

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003687_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q21029

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWYVASI

Database of Orthologous Groups

More...
OrthoDBi
226722at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q21029

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR043969, MAP3K_PH
IPR025136, MAP3K_TRAF-bd
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR013761, SAM/pointed_sf
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19039, ASK_PH, 1 hit
PF13281, DUF4071, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q21029-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQNNKRQVQ HNHEMSNDVC PLPLPPRGAP PPTAYHASRM AATSSSTNGS
60 70 80 90 100
FEKSAIPGNA RKLHVVIVID QKVQKNLRVR EMALKDVQKV ADTLNVNLTR
110 120 130 140 150
IDFDKLDFGE TETLDLFYNA DVALVDVTVT HQQPSLCYHI GVRESMGQSY
160 170 180 190 200
NMILTYWSPD PEYHIMDALK KTHAHLPMIV YIHHQDSNQL QSYDKNNNDD
210 220 230 240 250
DSKPPFARTN VPAKTITFQH RMKQVLKSVQ VEASAHSREK FMSDLRKARE
260 270 280 290 300
ITDGDQKNDY LDKMRTRLDN PDVLHPDTVS LMMLSYRDNQ NYGGMIRLVD
310 320 330 340 350
DLKRIPDCLK VVDTPVIRYQ YAFALNRRNK DGDRDLALNT VLSLVEGTTE
360 370 380 390 400
NEEKNGPLSP DVVCLAGRIY KDKFIASNYE DRESLNSAIE WYRRAFEMSP
410 420 430 440 450
LEYSGINLTT LLRASGEHFE NNLEMQQIAV VLNSLLGRKG ALQNLMEYWD
460 470 480 490 500
VATYFEVSVL AENYQKACEA ALMMVKLKPP VWYLKSTMEN IKLINRCAAT
510 520 530 540 550
ISPIEKEKQQ FLFWSEFFME ATEADTDISC PRYPVLILEL NKEFTPSYLT
560 570 580 590 600
LNNEEGTVIL SHVLENSQQK KIHQSELRGI HRWHFARNNI KAVTESKRDD
610 620 630 640 650
RQLFLYVHEN SDDFNLLFPT KAHCKKAYDD MKSMADVADG NYQGRVLSNP
660 670 680 690 700
DNEKIRFEYE LSNSNERVVL GKGTYGTVYA ARDMDTQRQI VVKEIEVKYD
710 720 730 740 750
EEVQPLMEEI SLHSTLCHAN IVQYLGCDLV GKDGSNDHFL IFMEHVPGGS
760 770 780 790 800
LSSLLRSKWG PMNENAMNYY GKQILEGLKY LHELKIVHRD IKGDNVLVNT
810 820 830 840 850
YSGVCKISDF GTCKRLAGLN PVTETFTGTL QYMAPEVIDH GQRGYGAPAD
860 870 880 890 900
IWSFGCTMVE MATGRPPFVE MQNPQAAMFR VGMFKTHPPI PTEITEKCRN
910 920 930 940 950
FIKSCFLPEA CDRPSAKDLL QDPFIYHNHH SISRTRSGSI NKKPATKIEL
960 970 980 990 1000
NHDKEKKEKS KNQREMLRST SHIGGMGVVE RSPPTPEPMS ATLTAGFSHV
1010 1020 1030 1040 1050
HSQTVSNALS TAREEKKLHL KIDHARNRTF SSSSPVPDGQ SSAGTNMSHP
1060 1070 1080 1090 1100
GFQLSQPSSP IVDDTNHPHL IVSPISLNTM GSPLSSAALL NRTISDESSN
1110 1120 1130 1140 1150
SSSRFFMLQK DSERRRSLGQ FMQDYKDLII DSWSTLLIKQ SDTELVVTVY
1160 1170 1180 1190 1200
MLEMLLDGMR DFLLKKDNTK MQKMIDDIRG LLDYDTAKIG QINLALYHFS
1210 1220 1230 1240 1250
DSIQPVLRRL DIKPHWMFAL SNLITSAVQC AISILSPDLS LLLHAQDNLP
1260 1270 1280 1290 1300
STSSIVAIRN SSLSEGEALI ESRPPSREER VREDRKELRT LQEENEILIE
1310 1320 1330 1340 1350
RLLQVERELN AQLKSGITRA NRFRDFAMYR NTYPPFRTPP VAHAPPTPPF
1360 1370 1380 1390 1400
SASCGAQPSG TFTNQPPSFA SIKPIAQKII MPPGTENNYQ VTRVQEELVS
1410 1420 1430 1440 1450
WLRGLEIDER SIALIASEAY TKSDMMDFVT RDELLSIGVG GGSSCRIMRA
1460 1470 1480 1490
IGEVRERQRR QPVFLSPMRS RDDSLDDYHS SSADDMYTGA AAETSSGN
Length:1,498
Mass (Da):169,654
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i751756B7483CDA2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3ATZ5A0A0K3ATZ5_CAEEL
Mitogen-activated protein kinase ki...
nsy-1 CELE_F59A6.1, F59A6.1
1,481Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD70472.1

NCBI Reference Sequences

More...
RefSeqi
NP_001293513.1, NM_001306584.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F59A6.1a.1; F59A6.1a.1; WBGene00003822

UCSC genome browser

More...
UCSCi
F59A6.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD70472.1
RefSeqiNP_001293513.1, NM_001306584.1

3D structure databases

SMRiQ21029
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ21029, 1 interactor
STRINGi6239.F59A6.1

Proteomic databases

EPDiQ21029
PaxDbiQ21029
PeptideAtlasiQ21029
PRIDEiQ21029

Genome annotation databases

EnsemblMetazoaiF59A6.1a.1; F59A6.1a.1; WBGene00003822
UCSCiF59A6.1, c. elegans

Organism-specific databases

WormBaseiF59A6.1a ; CE44901 ; WBGene00003822 ; nsy-1

Phylogenomic databases

eggNOGiKOG4279, Eukaryota
GeneTreeiENSGT00940000171895
HOGENOMiCLU_003687_1_1_1
InParanoidiQ21029
OMAiVWYVASI
OrthoDBi226722at2759
PhylomeDBiQ21029

Enzyme and pathway databases

ReactomeiR-CEL-2559580, Oxidative Stress Induced Senescence
SignaLinkiQ21029

Miscellaneous databases

Protein Ontology

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PROi
PR:Q21029

Gene expression databases

BgeeiWBGene00003822, Expressed in material anatomical entity and 5 other tissues
ExpressionAtlasiQ21029, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR043969, MAP3K_PH
IPR025136, MAP3K_TRAF-bd
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR013761, SAM/pointed_sf
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF19039, ASK_PH, 1 hit
PF13281, DUF4071, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSY1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q21029
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 16, 2015
Last sequence update: October 5, 2010
Last modified: September 29, 2021
This is version 171 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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