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Protein

Sodium channel protein

Gene

scn1lab

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • neuronal action potential Source: ZFIN
  • regulation of glycolytic process Source: ZFIN
  • regulation of ion transmembrane transport Source: UniProtKB-KW
  • regulation of oxidative phosphorylation Source: ZFIN
  • swimming behavior Source: ZFIN
  • synaptic signaling Source: ZFIN

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:scn1labImported
Synonyms:scn1LabImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-060906-1 scn1lab

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei126 – 149HelicalUniRule annotationAdd BLAST24
Transmembranei194 – 213HelicalUniRule annotationAdd BLAST20
Transmembranei225 – 246HelicalUniRule annotationAdd BLAST22
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Transmembranei390 – 417HelicalUniRule annotationAdd BLAST28
Transmembranei743 – 761HelicalUniRule annotationAdd BLAST19
Transmembranei773 – 796HelicalUniRule annotationAdd BLAST24
Transmembranei808 – 832HelicalUniRule annotationAdd BLAST25
Transmembranei853 – 881HelicalUniRule annotationAdd BLAST29
Transmembranei943 – 966HelicalUniRule annotationAdd BLAST24
Transmembranei1200 – 1218HelicalUniRule annotationAdd BLAST19
Transmembranei1239 – 1258HelicalUniRule annotationAdd BLAST20
Transmembranei1270 – 1290HelicalUniRule annotationAdd BLAST21
Transmembranei1316 – 1342HelicalUniRule annotationAdd BLAST27
Transmembranei1441 – 1464HelicalUniRule annotationAdd BLAST24
Transmembranei1523 – 1541HelicalUniRule annotationAdd BLAST19
Transmembranei1553 – 1571HelicalUniRule annotationAdd BLAST19
Transmembranei1583 – 1603HelicalUniRule annotationAdd BLAST21
Transmembranei1640 – 1668HelicalUniRule annotationAdd BLAST29
Transmembranei1744 – 1767HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ20JQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 423Ion_transInterPro annotationAdd BLAST295
Domaini492 – 692Na_trans_cytoplInterPro annotationAdd BLAST201
Domaini743 – 970Ion_transInterPro annotationAdd BLAST228
Domaini980 – 1193Na_trans_assocInterPro annotationAdd BLAST214
Domaini1198 – 1473Ion_transInterPro annotationAdd BLAST276
Domaini1522 – 1777Ion_transInterPro annotationAdd BLAST256

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili414 – 459Sequence analysisAdd BLAST46
Coiled coili481 – 503Sequence analysisAdd BLAST23
Coiled coili1967 – 1994Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
COG1226 LUCA
HOGENOMiHOG000231755
HOVERGENiHBG053100
PhylomeDBiQ20JQ8

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q20JQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQLLVPPG PDSFRPFLPE SLAAIEQRIA EEVAQRPKGE RRPDDDDENG
60 70 80 90 100
PKPNRDLEAG KPLPFIYGDV PPHMLSVPLE DLDTYYSNQK TFIVLNRGKA
110 120 130 140 150
IFRFNATPAL YILSPFNPLR RISIRVLVHS LFSFVIMCTI LTNCAFMTLS
160 170 180 190 200
NPPEWAKNVE YTFTGIYTFE SLIKILARGF CVGKFTFLRD PWNWLDFSVI
210 220 230 240 250
LMAYVTEFVN LGNVSALRTF RVLRALKTIS VIPGLKTIVG ALIQSVKKLS
260 270 280 290 300
DVMILTVFCL SVFALIGLQL FMGNLRQKCV KMPEVNVTDN LTDYSTELHN
310 320 330 340 350
STFNWTEYIS DSNNYYFIPG RRDALLCGNS SDAGQCPEGF TCIKAGRNPD
360 370 380 390 400
YGYTSFDTFS WAFLSLFRLM TQDFWENLYQ QTLRAAGKPY MIFFVLVIFL
410 420 430 440 450
GSFYLVNLIL AVVAMAYDEQ NQATIEEAQQ KEEEFQAMLE QLKRQQEEAQ
460 470 480 490 500
VAAAAATESG EYSGRGGLSE ESSSGGSRLS SKSAKERRNR RKKRKQREEE
510 520 530 540 550
EKADQEKFHK SASEDSIRRP GFRFSIDANR LSYEKKCSTP NQSLLSIRGS
560 570 580 590 600
LFSPRRNSRA SLFSFRGRAR DFGSENDFAD DEHSTFEDSD SRRGSLFVPR
610 620 630 640 650
CVERRSSTVS HCSLTAPRIM LPANGKMHCT VDCNGVVSLV GGTSVPTSPI
660 670 680 690 700
GRLLPEGTTT ESDVRKKRSG SHQPSDYLEE TVARKRAMSV ASILTNTMEE
710 720 730 740 750
LEESRQKCPP CWYKFANSFL IWDCSPAWLK VKEIMNMIVM DPFVDLAITI
760 770 780 790 800
CIVLNTLFMA MEHYPMTTQF SHLLSVGNLV FTGIFTAEMC LKVIALDPYY
810 820 830 840 850
YFQEGWNIFD GIIVSLSLME LGLANVEGLS VLRSFRLLRV FKLAKSWPTL
860 870 880 890 900
NMLIKIIGNS VGALGNLTLV LAIIVFIFAV VGMQLFGKSY RECVCKISES
910 920 930 940 950
CELPRWHMDD FFHSFLIVFR VLCGEWIETM WDCMEVAGQS MCLIVFMMVM
960 970 980 990 1000
VIGNLVVLNL FLALLLSSFS ADNLAATDDD SEMNNLQIAV GRIQKGIALV
1010 1020 1030 1040 1050
KSTLRQFLQS LFLAGSKPRS LNEEKPLDDL HSDGKENCLS NHAPVAVDLT
1060 1070 1080 1090 1100
KDYLKEGCVS PGNGVESHVK YGIEEGDYMS FIHNPSLTVT VPIAVGESDF
1110 1120 1130 1140 1150
ENLNTEDFSS ESSDVEGSKE KLPVDTVLSS SEGSTVDIRP PGEGAESVEL
1160 1170 1180 1190 1200
EPEESLDPEA CFTEGCVMRF QCCQVDVEKG KWKSWWILRK TCFIIVEHNW
1210 1220 1230 1240 1250
FESFIIFMIL LSSGALAFED IYIEQRKTIK TVLEYADKVF TYIFILEMLL
1260 1270 1280 1290 1300
KWVAYGFAKY FTNAWCWLDF LIVDVSLVSL VANALGYSEL SAIKSLRTLR
1310 1320 1330 1340 1350
ALRPLRALSR FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF
1360 1370 1380 1390 1400
AGKYYYCVNI TNDELFPVSV VNNKSDCYAL IQNNDTARWK NVKINFDNVG
1410 1420 1430 1440 1450
AGYLALLQVA TFKGWMDIMY AAVDSRDLEQ QPVYETNLYM YLYFVIFIIF
1460 1470 1480 1490 1500
GSFFTLNLFI GVIIDNFNQQ KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP
1510 1520 1530 1540 1550
QKPIPRPANK FQGLVFDLIT KQAFDIIIMI LICLNMVTMM VETDDQTEDM
1560 1570 1580 1590 1600
DNILYWINLV FIILFTGECV LKMISLRHYF FTIGWNVFDF VVVILSIVGM
1610 1620 1630 1640 1650
FLSEMIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA
1660 1670 1680 1690 1700
LFNIGLLLFL VMFIYAIFGM SNLAYVKREA GIDDMFNFET FGNSMLCLFQ
1710 1720 1730 1740 1750
ITTSAGWDGL LAPILNKQDP DCDSEMEHPG SFYRGNCGNP SVGIFFFVSY
1760 1770 1780 1790 1800
IIICFLIVVN MYIAVILENF SVATEESAEP LSEDDFEMFY EVWERFDPNA
1810 1820 1830 1840 1850
TQFVEYNKLS DFAVFLDPPL RIAKPNKIQL IAMDLPMVSG DRIHCLDILF
1860 1870 1880 1890 1900
AFTLRVLGEE GEMDALRGQM EDRFMASNPS KVSYEPITTT LRRKQEEMSA
1910 1920 1930 1940 1950
VVIQRAFRRH RIRQTVKKAS EAYRKQLQDG GGHIPEKEVL VIGKFQENSA
1960 1970 1980 1990
SDKTDMTPSS ASPPSYNSVA KSEKDKYEKE RREKEDKAKD ARDRKK
Length:1,996
Mass (Da):226,418
Last modified:April 18, 2006 - v1
Checksum:i82F9524997762958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ149504 mRNA Translation: ABA54919.1
UniGeneiDr.87125

Similar proteinsi

Entry informationi

Entry nameiQ20JQ8_DANRE
AccessioniPrimary (citable) accession number: Q20JQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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