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Entry version 105 (02 Jun 2021)
Sequence version 1 (18 Apr 2006)
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Protein

Sodium channel protein

Gene

scn12aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scn12aaImported
Synonyms:scn5LaaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060908-2, scn12aa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei99 – 118HelicalUniRule annotationAdd BLAST20
Transmembranei125 – 148HelicalUniRule annotationAdd BLAST24
Transmembranei251 – 274HelicalUniRule annotationAdd BLAST24
Transmembranei391 – 418HelicalUniRule annotationAdd BLAST28
Transmembranei706 – 724HelicalUniRule annotationAdd BLAST19
Transmembranei736 – 759HelicalUniRule annotationAdd BLAST24
Transmembranei816 – 844HelicalUniRule annotationAdd BLAST29
Transmembranei904 – 929HelicalUniRule annotationAdd BLAST26
Transmembranei1128 – 1147HelicalUniRule annotationAdd BLAST20
Transmembranei1168 – 1184HelicalUniRule annotationAdd BLAST17
Transmembranei1196 – 1215HelicalUniRule annotationAdd BLAST20
Transmembranei1260 – 1280HelicalUniRule annotationAdd BLAST21
Transmembranei1367 – 1390HelicalUniRule annotationAdd BLAST24
Transmembranei1449 – 1467HelicalUniRule annotationAdd BLAST19
Transmembranei1479 – 1501HelicalUniRule annotationAdd BLAST23
Transmembranei1513 – 1532HelicalUniRule annotationAdd BLAST20
Transmembranei1580 – 1602HelicalUniRule annotationAdd BLAST23
Transmembranei1670 – 1693HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 424Ion_transInterPro annotationAdd BLAST297
Domaini511 – 603Na_trans_cytoplInterPro annotationAdd BLAST93
Domaini706 – 934Ion_transInterPro annotationAdd BLAST229
Domaini943 – 1123Na_trans_assocInterPro annotationAdd BLAST181
Domaini1127 – 1398Ion_transInterPro annotationAdd BLAST272
Domaini1448 – 1703Ion_transInterPro annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 50DisorderedSequence analysisAdd BLAST24
Regioni557 – 578DisorderedSequence analysisAdd BLAST22
Regioni1034 – 1076DisorderedSequence analysisAdd BLAST43
Regioni1913 – 1932DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1034 – 1055Acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
DCLAMND

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q20JQ5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q20JQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATMLLPAGP DGLRPFTRES LAAIEQRISE ERARNTKDYK ADPGDVEEPK
60 70 80 90 100
PRADLEVGKV LPRIFGEIPA GLVGVPLEDI DPFYFRNQKT FIVLNKGKAI
110 120 130 140 150
FRFSATSALY IFSPFHCIRR ISIRILVHSL FSLFIMCTIL TNCCFMAMSD
160 170 180 190 200
PPLWTKYLEY TFTGIYTFES LIKILARGFC TECFTFLRDP WNWLDFSVIV
210 220 230 240 250
MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLAD
260 270 280 290 300
VMILTVFCLS VFALIGLQLF MGILRQKCVR SIGHCVNSTY PGNGSFVCNN
310 320 330 340 350
KTWLSVKDFL TNEDNFYKIE GSKDALICGY SSDAGKCPDG FDCLKTSRNP
360 370 380 390 400
NYGYTSFDTF GWAFLGLFRL MTQDYWESLY HQTLRSAGKT YMIFFVLVIF
410 420 430 440 450
LGSFYLVNLI LAVVAMAYEE QNQATIAEAW AKEREFQLAM EHLRKEQRAL
460 470 480 490 500
AKQRRKEAEM ALAADFCPSP FSRKDSIKCR TRTRSHRTLS EEIEDSFLPK
510 520 530 540 550
FEPLDEKPAH PLLATLSSHP LSTRRGSQMS IFTFRPRNSS EADFADDEHS
560 570 580 590 600
VADYGRSRAG SMATPWHKHR TGSIRSHSSQ VFTPTLANGR LNISLEQNGI
610 620 630 640 650
TGIGLHTPTT GPKFSMEKVK EGTEPECQNE QVKLTVDVQE EVLPPRRKRG
660 670 680 690 700
LSSVSFFSDA MDELEEARQK CPPCWYEFAQ KYLIWTCSPA WLRVKEGLKV
710 720 730 740 750
MVMDPFLDLA ITICIVLNTL FMALEHYPMT DEFNSMLSIG NLVFTGIFTA
760 770 780 790 800
EMVLKIFALD PYYYFQQGWN IFDGIIVCLS LMELGLSNVE GLSVLRSFRL
810 820 830 840 850
LRVFKLAKSW PTLNTLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG
860 870 880 890 900
KNYQDCVCKI SYDCTLPRWH MKDFFHSFLI VFRVLCGEWI ETMWDCMEVA
910 920 930 940 950
GQPLCILVFM LVMVIGNLVV LNLFLALLLS SFSSDNLSAP DEDGEMNNLQ
960 970 980 990 1000
IAIARIHCGF SWLLNGIKDL FSGNLTRHRR KSKEAQVTLN HTECNGGLGS
1010 1020 1030 1040 1050
LEKYVFPETE DSYMTNPNLT ICVPIAPGES DVEFLEEEEE EEDTESSEDE
1060 1070 1080 1090 1100
EEKQEVISLS EGSTVDLRKP GEDEEEYSEM ADDGMDPEEC FPEFCMQRCK
1110 1120 1130 1140 1150
CCNINTTQGL GQMWWRLRKT CYQIVEHSWF ETFIILMILL SSGALAFEDI
1160 1170 1180 1190 1200
YIEQRKVVKV VLEYADKVFS YIFVLEMFLK WIAYGFKKYF TNYWCWLDFL
1210 1220 1230 1240 1250
IVDVSLISLV ANSLGYSDFG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL
1260 1270 1280 1290 1300
IGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFGKCVNRT GFIHNASIVN
1310 1320 1330 1340 1350
NKTECLSMND TQFYWTKVKV NFDNVGLGYL SLLQVATFKG WMEIMYAAVD
1360 1370 1380 1390 1400
SRGVEDQPIK EINLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKRMI
1410 1420 1430 1440 1450
GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI PRPMNILQGF FFDLVSKQAF
1460 1470 1480 1490 1500
DITIMMLIIL NMITMMVETD EQSARMETIL NNINLAFIVI FTTECLIKIF
1510 1520 1530 1540 1550
ALRCYFFTIS WNIFDFVVVI LSIVGIVLAD IIEKYFVSPT LFRVIRLARI
1560 1570 1580 1590 1600
GRVLRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YAIFGMANFA
1610 1620 1630 1640 1650
YVKKQGGIDD MFNFETFGNS MICLFQITTS AGWNNLLDPI LNNSPEECSS
1660 1670 1680 1690 1700
SFANTGTNTK GNCGHPSVGI TFFVSYIIIS FLIVVNMYIA IILENFSVAT
1710 1720 1730 1740 1750
EESTEPLSED DFEMFYEVWE KFDVEATHFI EYAKLSNFAD SLSEPLRIAK
1760 1770 1780 1790 1800
PNKIKLIHMD LPMVNGDRIH CLDILFAFTK RVLGETGEMD ALKQQMEEKF
1810 1820 1830 1840 1850
MVTNPSKISH EPITTTLRRK QEEISATLIQ RAYRAHLIRR QMKQASYLYR
1860 1870 1880 1890 1900
HINQETPWSE EDSAPEQEGL IASMIKENYG PEKMVGTLCY ASSPPSYEAV
1910 1920 1930
TRSPRDHFKL LISDSRSNEP HKSEETYEET FL
Length:1,932
Mass (Da):220,482
Last modified:April 18, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A84796BFDAB88E1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ149507 mRNA Translation: ABA54922.1

NCBI Reference Sequences

More...
RefSeqi
NP_001038387.1, NM_001044922.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
795688

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:795688

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ149507 mRNA Translation: ABA54922.1
RefSeqiNP_001038387.1, NM_001044922.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi795688
KEGGidre:795688

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
795688
ZFINiZDB-GENE-060908-2, scn12aa

Phylogenomic databases

OMAiDCLAMND
OrthoDBi172471at2759
PhylomeDBiQ20JQ5

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit
PRINTSiPR00170, NACHANNEL
SMARTiView protein in SMART
SM00015, IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ20JQ5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20JQ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: June 2, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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