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Entry version 90 (17 Jun 2020)
Sequence version 1 (18 Apr 2006)
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Protein

Sodium channel protein

Gene

scn5lab

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scn5labImported
Synonyms:scn12abImported, scn5LabImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060908-3 scn5lab

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei125 – 148HelicalUniRule annotationAdd BLAST24
Transmembranei224 – 245HelicalUniRule annotationAdd BLAST22
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Transmembranei393 – 420HelicalUniRule annotationAdd BLAST28
Transmembranei707 – 725HelicalUniRule annotationAdd BLAST19
Transmembranei737 – 760HelicalUniRule annotationAdd BLAST24
Transmembranei772 – 796HelicalUniRule annotationAdd BLAST25
Transmembranei817 – 845HelicalUniRule annotationAdd BLAST29
Transmembranei905 – 930HelicalUniRule annotationAdd BLAST26
Transmembranei1148 – 1167HelicalUniRule annotationAdd BLAST20
Transmembranei1188 – 1207HelicalUniRule annotationAdd BLAST20
Transmembranei1213 – 1235HelicalUniRule annotationAdd BLAST23
Transmembranei1280 – 1300HelicalUniRule annotationAdd BLAST21
Transmembranei1387 – 1410HelicalUniRule annotationAdd BLAST24
Transmembranei1469 – 1487HelicalUniRule annotationAdd BLAST19
Transmembranei1499 – 1521HelicalUniRule annotationAdd BLAST23
Transmembranei1533 – 1552HelicalUniRule annotationAdd BLAST20
Transmembranei1600 – 1622HelicalUniRule annotationAdd BLAST23
Transmembranei1690 – 1713HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 426Ion_transInterPro annotationAdd BLAST299
Domaini450 – 655Na_trans_cytoplInterPro annotationAdd BLAST206
Domaini707 – 934Ion_transInterPro annotationAdd BLAST228
Domaini944 – 1143Na_trans_assocInterPro annotationAdd BLAST200
Domaini1147 – 1419Ion_transInterPro annotationAdd BLAST273
Domaini1468 – 1723Ion_transInterPro annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 53DisorderedSequence analysisAdd BLAST22
Regioni470 – 500DisorderedSequence analysisAdd BLAST31
Regioni1006 – 1103DisorderedSequence analysisAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili417 – 458Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi472 – 500PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1020 – 1035PolarSequence analysisAdd BLAST16
Compositional biasi1043 – 1064AcidicSequence analysisAdd BLAST22
Compositional biasi1065 – 1095PolyampholyteSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04838

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q20JQ4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR043203 VGCC_Ca_Na
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037 PTHR10037, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q20JQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAILFPPGP DSLHRFTRES LAGIEQRIAE EEARNAKRYQ EDRGDVEPPK
60 70 80 90 100
PRADLEAGKQ LPRIFGDIPS ALVGVPLEDI DPFYFQNRRT FIVLNKGKAI
110 120 130 140 150
FRFSATSALY IFSPFHPIRR ASIRILVHSL FSLFIMCTIL TNCCFMAMSE
160 170 180 190 200
PAQWAKYVEY TFTGIYTFES LIKILARGFC IGPFTFLRDP WNWLDFSVIL
210 220 230 240 250
MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLAD
260 270 280 290 300
VMILTVFCLS VFALIGLQLF MGNLRQKCVR SASQCLNTTL PTYNNSTFIC
310 320 330 340 350
NNRSWASLEE FFNNEDNFFK VEGAKDALIC GNASDAGKCP DGFECLKTGR
360 370 380 390 400
NPNYGYTSFD TFGWAFLSLF RLMTQDYWEN LYHHTLRSAG KAYMVFFVVV
410 420 430 440 450
IFLGSFYLVN LILAVVAMAY EEQNQATIAE ALQKEQEFQL AMEQLKKEQQ
460 470 480 490 500
AAQKAQETES ILTADVSPFS TQDKAKLERR KSSRPLSEGT GEDKPAKLDP
510 520 530 540 550
IEGIKQTHSL LVRTLSLRAR RESAVSIFNF RPVNKDSELD FADDEFSNHG
560 570 580 590 600
DSDSRGGALA LPWSRRRTSA QSSCSHSSQF FFPSFNINGK LMVAVEQNGI
610 620 630 640 650
SSQGPLTPMT PLTPLPACTM EKLKEESGQN SSNELSSMLL PQLPPEGRDR
660 670 680 690 700
ALSATSYITD AMEELEEAQQ KCHPCWYVFA HKYLVWTCSP RWLKVKEWVK
710 720 730 740 750
IMVMDPFLDL AITICIVLNT LFMALEHYPM TDEFNRMLSV GNLVFTGIFT
760 770 780 790 800
AEMVLKIIAL DPYYYFQQGW NIFDSLIVSL SLMELGLSNV EGLSVLRSFR
810 820 830 840 850
LLRVFKLAKS WPTLNTLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF
860 870 880 890 900
GKNYDLCVCK ISKDCTLPRW HMKDFFHSFL IVFRVLCGEW IETMWDCMEV
910 920 930 940 950
AGQPLCILVF MLVMVIGNLV VLNLFLALLL SSFSADNLSA PDEDGEMNNL
960 970 980 990 1000
QIAIARIQRG MLWLRQALCD FFNGNFKRRR QKAKEAKAML KLKRLTQQAH
1010 1020 1030 1040 1050
WAEGNGTAGV IERSSGAGSG EDDSYMTNPN LTISVPIAPG ESDVEFPEEE
1060 1070 1080 1090 1100
DEEEDEEEEA SASSDEEPEP CKPRDDTSLS EGSTIDLRKP GEEEDEYSEM
1110 1120 1130 1140 1150
AEEAMDPENC FPDVCVRHFK CCDINTSEGL GRAWWRLRKT CYQIVEHSWF
1160 1170 1180 1190 1200
ETFIIFMILL SSGALAFEDI YIDQRKVVKV ILEYADKIFT YIFILEMSLK
1210 1220 1230 1240 1250
WIAYGFRKYF TNYWCWLDFL IVDVSLVSLV ANTLGYSDFA AIKSLRTLRA
1260 1270 1280 1290 1300
LRPLRALSRF EGMRVVVNAL IGAIPSIMNV LLVCLIFWLI FSIMGVNLFA
1310 1320 1330 1340 1350
GKFGRCVNRT GFIYNSSDIN NRSECLEMNS TQYYWTKVKV NFDNVGAGYL
1360 1370 1380 1390 1400
ALLQVATFKG WMEIMYAAVD SRAVEEQPIK ENSLYMYLYF VIFIIFGSFF
1410 1420 1430 1440 1450
TLNLFIGVII DNFNQQKRKL GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI
1460 1470 1480 1490 1500
PRPPNPVQGF FFDLVSKQAF DILIMLLIIL NMVTMMVETD EQSPSIKHIL
1510 1520 1530 1540 1550
DCINLVFIVI FTSECILKII ALRCYFFTVS WNIFDFVVVI LSIVGIVLAD
1560 1570 1580 1590 1600
IIEKYFVSPT LFRVIRLARI GRILRLIRGA KGIRTLLFAL MMSLPALFNI
1610 1620 1630 1640 1650
GLLLFLVMFI YAIFGMANFA YVKKQGGIDD MFNFETFGNS MICLFQITTS
1660 1670 1680 1690 1700
AGWDNLLSPI LNTPPEECDP EIPHTGTNAR GNCGKPSVGI TFFVTYIIIS
1710 1720 1730 1740 1750
FLIVVNMYIA IILENFSVAT EESTEPLSED DFEMFYEVWE KFDPEATQFI
1760 1770 1780 1790 1800
EYLKLSDFAD TLSEPLRIGK PNKIKLISMD LPMVSGDKIH CLDILFAFTK
1810 1820 1830 1840 1850
RVLGESGEMD ALKQQMEEKF MMANPSKISY EPITTTLRRK QEEVSAIMIQ
1860 1870 1880 1890 1900
RSYRRHLIRR QLKQASLLYR QMTMPDADKA GDSSPESQGL IVSMIMENYA
1910 1920 1930 1940 1950
TEAEITISAT SSPPSYDSVT RATSEIFHAL IPEETNEILS EHLADAEKES

ETFL
Length:1,954
Mass (Da):221,848
Last modified:April 18, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBB7743C49AA5D5B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ149508 mRNA Translation: ABA54923.1

NCBI Reference Sequences

More...
RefSeqi
NP_001038588.1, NM_001045123.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
566868

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:566868

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ149508 mRNA Translation: ABA54923.1
RefSeqiNP_001038588.1, NM_001045123.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi566868
KEGGidre:566868

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
566868
ZFINiZDB-GENE-060908-3 scn5lab

Phylogenomic databases

KOiK04838
OrthoDBi172471at2759
PhylomeDBiQ20JQ4

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR043203 VGCC_Ca_Na
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037 PTHR10037, 2 hits
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ20JQ4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q20JQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: June 17, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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